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38 Cards in this Set
- Front
- Back
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dosing for baclofen |
5mg TID up to 80mg total daily |
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what is the dose for central acting muscle pulls? |
cyclobenzaprine 5 mg 3 x day |
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dosing for benzo- anxiety or acute muscle strain |
diazepam 2-10mg 3-4x a day IM or IV for muscles spasm- 5-10mg |
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dose for non–benzodiazepine |
Buspirone (BuSpar) |
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dose for benzodiazepines- anxiety |
xanax (Alprazolam) |
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lithium salts for mania dose |
lithium carbonate ER 600 mg 2x day |
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valproic acid for mania dose |
depakote ER 1500mg a day |
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anticonvul. for mania dose |
equetrol 400 mg 2x day |
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PRICE |
protect, rest, ice, compress, elevate |
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who are the muscle relaxants |
centrally-acting muscle relaxants- cyclobenzaprine benzodiazepine (diazepam) acute tx of pulls baclofen (lioresal) **good for spasisity tizanidone (Zanaflex) botulinum toxin |
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ADR of cyclobenzaprine |
serotonin syndrome if mixed with SSRI, SNRI, or tramadol cardiac like tricyclic antidepressants
do NOT mix with alcohol or other drugs careful with even milk hepatic impairment |
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MOA of benzo |
diazepam facilitates GABA action CNS |
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ADR of benzos |
sedation dependence potential amnesia effect |
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MOA of baclofen |
works in brain and spinal cord less sedating then diazepam |
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ADR of baclofen |
drowsiness, increased seizures withdrawal |
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intrathecal pump |
baclofen avoids peripheral ADR and give smaller amt of drugs if stop pump it is a big deal resp depression, HOTN, infx, drowsiness |
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tizanidine MOA |
chemical variant of clonidine less HOTN effect pre and postsynaptic inhibition in spinal cord |
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ADR of tizanidine |
less muscle weakness as others CNS: drowsiness, dizziness HOTN, asthenia and hep toxicity |
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what is your chronic therapy for anxiety disorders
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SSRIs = first line
tricyclic antidepressants = second line |
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what are the benzodiazepines
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alprazolam (Xanax)– short T1/2
Clordiazepoxide (Librium)– delirum tremens Clonazepam (Klonopin)– long T1/2 Clorazepate (Tranxene–T)– turns into diazepam Diazepam (Valium)– muscle relaxant Lorazepam (Ativan)– tx for seizures, for old ppl Oxazepam |
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MOA for benzodiazepines
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works on GABA to open Cl channels
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what is the benzodiazepines used for as skeletal muscle relaxation
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diazepam
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what is the benzodiazepines that are used for seizures
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lorazepam (Ativan) for status epilepticus |
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important way taking pts off benzodiazepines |
need to TAPER slowly |
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who are bad candidates for benzodiazepines
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people who have dependent behaviors
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ADR of benzodiazepines
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–CNS: ataxia, cognitive dysfunction, depression, dizziness, drowsiness, fatigue, irritability, memory impairment, sedation |
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what is the non–benzodiazepines |
Buspirone (BuSpar)
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MOA of non–benzodiazepine
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doesn't affect benxodiazepine– GABA receptor
serotonin receptor partial agonist D2,3,4 dopamine antagonist (presynaptic) takes 2 wks to work |
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ADR of non–benzodiazepine
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rare
CNS: dizziness, drowsiness, confusion, anger/hostility GI: nausea no abuse potential |
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what are mood disorders characterized by
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episodes of mania
hypomania major depression |
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what are subtypes of bipolar disorder |
bipolar 1: manic and mixed episodes
bipolar 2: one hypomanic episode, at least 1 major depressive episode, and absence of mania and mixed episode |
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what are the lithium salts
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lithium carbonate
lithium citrate |
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MOA of lithium salts
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GABA rises
dopamine decreases |
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aproved and unapproved uses of lithium salts
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approved: management of bipolar disorder, tx of mania
unapproved: antidepressant, aggression, PSTD, conduct disorder in children |
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Kinetics of lithium salts
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renal impairment |
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benzodiazepines examples & uses
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diazepam [valium]– anxiety
lorazepam– short term anxiety symptoms, depression alprazolam [xanax]– short term anxiety, panic, depression clonazepram– panic disorder oxazepam clorazepate [tranxene–T] |
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What is chronic therapy for anxiety disorders
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SSRI* or tricyclic antidepressants
*prefered |
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Benzo SE
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central nervous system– ataxia, cog dysfunction, depression, dizzy, sedation |
