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27 Cards in this Set

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penicillin G
penicillin V
Staphylococcus aureus, Streptococcus pneumonia (MIC 0.1-1 mcg/ml)
Enterococcus (synergy with aminoglycoside)
Pen G (Neisseria meningitidis)
nafcillin, oxacillin
Staphylococcus aureus
Streptococcus pneumonia
ampicillin/sulbactam
Staphylococcus aureus, Streptococcus pneumonia, gram negative (E. coli, Klebsiella, Haemophilus influenza) and anaerobes (Bacteroides)
ticarcillin/potassium clavulanate
Staphylococcus aureus, Streptococcus pneumonia, greater gram negative (E. coli, Klebsiella, Haemophilus influeza, Pseudomonas) and anaerobes (Bacteroides)
1st generation Cephalosporin
gram positive (Staphylococcus, Beta-hemolytic streptococcus)
minimal gram negative (E. coli, Klebsiella)
2nd generation Cephalosporin
Equal gram neg/pos coverage
gram positive (Staphylococcus, beta-hemolytic streptococcus, Streptococcus pneumonia)
gram negative (Haemophilus influenza)
anaerobes - some activity against Bacteroides and Clostridium sp
3rd generation Cephalosporin
greater gram negative than gram positive coverage
gram positive (beta-hemolytic streptococcus, streptococcus pneumonia)
gram negative (E. coli, Haemophilus influenza, Proteus mirabilis)
anaerobes - some activity against Bacteroides and Clostridium sp
4th generation Cephalosporin
similiar to 3rd generation ceph. coverage
very good coverage for Pseudomonas aeruginosa and limited anaerobic coverage
Macrolides
gram positive (Staphylococcal and Streptococcal sp)
gram negative (Haemophilus influenza, Moraxella, Legionella and Neisseria)
atypical (Mycoplasma pneumoniae, Chlamydia)
Tetracyclines
gram positive (Staphylococcal and Streptococcal sp)
gram negative (Haemophilus influenza, E.coli, Klebsiella and Neisseria sp.)
atypical (mycoplasma pneumonia, chlamydia)
other (Rickettsia, Borrelia)
Nitrofurantoin
UTIs caused by susceptible gram positive (more) and gram negative organisms; not so much againt Pseudomonas, Serratia, and Proteus
Fluoroquinolones
gram positive (Staphylococcus aureus, Streptococusi aeroginosa)
gram negative (E.coli, Klebsiella sp, H. influenza, Pseudomonas aeruginosa)
atypical (mycoplasma pneumoniae) - Levo
anaerobic (Bacteroides sp, Fusobacterium sp - moxi/gati)
Streptococci pneumoniae - levo/moxi/gati
1st DOC for CAP
Glycopeptides
Severe Staph and Strept sp. including MRSA
coagulase (-) staph and enterococcus faecium/faecalis.
Use in combo with aminoglycoside for strept and staph endocarditis.
Life threatening infections of lower respiratory tract, bone, skin, and skin structure and septicemia
Aminoglycosides
gram positive (S. aureus, Enterococcus sp. (faecalis, faecium)
gram negative (E. coli, Klebsiella, Proteus, Enterobacter, Pseudomonas aeruginosa, Serratia sp.)
other (Salmonella)
not effective for group D Streptococcus and anaerobes
Always used in synergy
Sulfonamides
gram positive (Staphyloccus aureus)
gram negative (H. influenza, E. coli, Klebsiella, Proteus)
other (Toxoplasmosis, Malaria)
trimethoprim/sulfamethoxazole
gram positive (Staph aureus, S. pneumoniae)
gram negative (H. influenza, E.coli, Klebsiella, Proteus, enterobacter sp.)
other (PCP, cholera, salmonella)
Lincosamides
gram positive (staph. aureus, strep pneumoniae)
(not used alone unless pt. is allergic to other agents)

anaerobes (Bacteroides, actinomyces, peptococcus, peptostreptococcus)
Metronidazole
anaerobes (Bacteroides, Actinomyces, Peptooccus, Peptostretococcus, clostridium)

other (H. pylori, and anaerobic protozoa including trichomonas and giardia sp)
Carbapenems
gram positive (staph aureus (MSSA), strept viridans and pyogenes, enterococcus faecalis)
gram negative (E.coli, Klebsiella, proteus, H. influenza, Pseudomonas aeruginosa, Acinetobacter sp. serratia marcesens)
anaerobes (Bacteroides, peptococcus, peptostretpococcus, clostridium)

meropenem approved for bacterial meningitis in children (>3 month old) s. pneumoniae, H. influ, and N. meningitides
Chloramphenicol
gram positive (staph aureus, enterococcus faecium/faecalis (VRE))
gram negative (H. influ, N. meningitides)
anaerobes (Bacteroides)
other (Rickettsia, Salmonella)
Rifampin
treatment and prevention of TB, leprosy, meningococcal meningitis and H. influenza prophylaxis. Used in combo with other anti-infectives in the treatment of staph infections for synergy
Streptogramins
complicated skin/skin structure infections caused by methicillin susceptible and methicillin resistant staph aureus or strept pyogenes
life-threatening VRE infections
Oxalodinones
complicated skin/skin structure infections caused by methicillin susceptible/methicillin resistant staph aureus or strept pyogenes
nosocomial pneumonia caused by staph aureus (MSSA or MRSA) or s. pneumoniae

proposed for DOC of VAP induced VRSA
linezolid has good lung penitrations
Monobactams
gram negative (p. aeruginosa, E. coli, Enterobacter, Klebsiella, proteus, serratia and haeomophilus sp.)
Lipopeptides
complicated skin infections caused by MSSA, strept pyogenes and vacomycin susceptible strains of enterococcus faecalis. bloodstream infections including those with right-sided endocarditis, caused by MSSA and MRSA
Ketolides
CAP (strept pneumoniae, haemophilus influ, moraxella catarrhalis, chlamydophila pneumoniae, or mycoplasma pneumoniae)

FDA for bronchitis, acute sinusitis
Glycylcycline
treatment of skin infections caused by MSSA, E. coli, S pyogenes, Bacteroides fragilis, and vancomycin-sensitive entorococcus faecalis

treatment of complicated intra-abdominal infections. Other organisms that have demonstrated in-vivo and in-vitro activity: E. coli, klebsiella pneumoniae, enterobacter cloacae, bacteroides sp.

potent but no effect on pseud aueruginosa