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14 Cards in this Set
- Front
- Back
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Division delay caused by |
Disruption in the mitotic index (MI) |
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Mitotic index (MI) |
Ratio of number of mitotic cells to number of cells in irradiated area |
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Mitotic delay will cause |
Decrease in M1(mitosis) for the cell population, fewer cells will enter mitosis stage and split |
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Division delay results in a delay in G2 phase, causing |
Mitotic delay |
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Interphase death |
Irradiation of cell during G1, S, or G2 results in cell death |
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Interphase death can occur in |
Non-dividing cells & rapidly dividing cells |
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Radiosensitive cells succumb to Interphase death |
At lower radiation doses than radio resistant doses |
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A mature lymphocyte is sensitive to Interphase death at doses |
As low as 50cGy |
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Reproductive failure |
Most common, aka mitotic death |
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Reproductive failure is |
A decrease in the reproductive integrity |
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Reproductive failure main cause is |
Overall damage to the chromosomes due to radiation dose |
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Unrelated to mitosis, cells exposed to radiation have exhibited cellular apoptosis due to |
Nuclear fragmentation Cell lysis Phagocytosis of chromatin bodies by neighboring cells |
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Law of Bergonie and Tribondeau |
Immature rapidly dividing cells are damaged at lower radiation doses than mature non-dividing cells |
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Law of Bergonie and Tribondeau states that ionizing radiation is more effective against cells that |
Are actively mitotic Are undifferentiated Have a long mitotic future |
