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28 Cards in this Set
- Front
- Back
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site of oxytocin synthesis?
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paraventricular nucleus
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how is oxytocin stored?
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complex w/ neurophysin
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Therapeutic uses of oxytocin?
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Induce labor
Augment labor Control post-partum hemorrhage |
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what's up with uterine sensitivity to oxytocin?
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inc as pregnancy progresses
inc w/ estrogen |
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MOA of oxytocin
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Gq and G11 coupled-->PLC/IP3
Enhance Ca channels Inc prostaglandins for contraction |
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High doses of pitocin do?
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antidiuretic (dec free water clearance)
vasoactive (can cause hypotension and reflex tach) |
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other Oxytocics?
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Ergonovine or Methylergonovine
PGE2 (dino) and PGF2 (carbo) Prostaglandin Inhibitors (delay labor) PGI2 vasodilates PGE1 analog-->abortion |
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where is ADH synthesized?
how is it stored? |
Supraoptic nuclei
stored in complex |
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Types of vasopressin receptors?
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V-1a
V-1b V-2 |
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Kickers for V-1a
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Most ubiquitous
Vascular smooth muscle adrenal glands renal tissues myometrium hepatocytes CNS |
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Kickers for V-1b
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More limited distribution
Ant. pit brain pancreas adrenal medulla |
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Kickers for V2 receptor
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More potent receptor
Present in renal collecting duct system Epithelial cells of thick asc limb vascular endothelial cells |
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type of receptor for V1 and V2
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V1: Gq --> PLC's
V2: cAMP |
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V1 effects on renal
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Contraction of stuff
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V2 effects on renal
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inc water perm in collecting duct
inc urea transport inc Na transport |
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what should i appreciate?
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the availability of vasopressin receptor agonists and antagonists
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Drug interactions w/ ADH?
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enhancers
NSAIDs Carbamazepine and chlorpropamide inhibitors PG's Lithium Demeclocycline Ethanol and phenytoin |
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SE's of vasopressin therapy?
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Facial pallor
Inc Intestinal activity Complicate CAD Peripheral vasoconstriction and gangrene Water intoxication Mild facial flushing and HA Allergic rxn |
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Actions of Ergot Alkaloids?
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inc activity of uterus
dose dependent induce labor control post-partum bleeding |
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Which ergot is most used for labor stuff?
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Ergonovine
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agent of choice to induce labor?
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oxytocin
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drug to counteract labor contractions?
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terbutaline (beta 2 agonist)
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when trying to stop uterine motility, what stages of the cervix are best?
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< 4cm dilated
<80% effaced |
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Other drugs besides terbutaline to inhibit uterine contractions?
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Ritodrine (beta 2)
Magnesium sulfate CCB's Prostaglandin Synthetase Inhibitors (indomethacin) Oxytocin Antagonists |
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SE's of beta 2's?
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hypotension
reflex tach |
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SE's of magnesium sulfate?
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cardiac arrest
resp depression |
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Most powerful stimulators of vasopressin release?
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Baroreceptors in vasculature
i.e. blood volume |
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kicker for pharmacokinetics of vasopressin?
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not ORAL!
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