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3 Cards in this Set
- Front
- Back
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Digoxin. Describe the mode of actions and why and how woudl you give a loading dose.
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1. Inhibits the Na+-K+-ATPase channel
2. Increase in intracellular Na+ 3. Reverses the Na+-Ca2+ channel to increase intracellular Ca2+. Supraphsyiological quantity of “trigger calcium” enters myocyte 4. Increased release of stored calcium from SER 5. Increased activation of contractile proteins Digoxin improves the baroreceptor reflex sensitivity such that PSNS stimulation may return. End result is ↓HR & vasodilation. High VOD = LD Narrow Therapeutic window= no LD Therefore give smaller loading dose |
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Pimobendan
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An inodilator
– +ve inotrope & vasodilator Increases the sensitivity of the contractile proteins to existing levels of intracellular calcium – increases sensitivity of troponin C to calcium. does not increase myocardial consumption of O2. |
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Name 3 side effects.
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Decreased myocardial contractility
decreased CO hypotension Vasodilation hypotension Slows atrioventricular (AV) impulse conduction Bradycardia |
