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9 Cards in this Set
- Front
- Back
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When taking a family history, how many generation should be included in the pedigree?
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Three.
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What characteristics indicated a positive family history.
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First degree relatives with monogenic conditions. First or second degree relatives with complex d/o (i.e., cancer, diabetes).
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In the context of patient counseling and testing decisions, what are the red flags for a woman with a history of breast cancer?
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Number of relatives affected. Degreeof relationship to proband. Age of onset. Least affected sex. Related d/o. Example: patient with headaches shows family hx of breast cancer in mother, sister, aunts, and Uncle George. They all developed BRCA before age 45 years and three also developed ovarian cancer.
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What are the four assumptions of the H-W principle?
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The population mates randomly, allele frequencies maintain throughout generations, the population is big, and there is no gene flow.
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Give the frequencies for the following genotypes: AA, Aa, and aa.
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AA = p2. Aa = 2pq. aa = q2.
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P = ?. Q = ?
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P = the frequency of the dominant allele. Q = the frequency of the recessive allele.
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(p + q)2 = ?
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(p + q)2 = 1
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