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10 Cards in this Set
- Front
- Back
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What is allele frequency?
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Number of a specific type of allele divided by the total number of alleles in the gene pool
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What is the gene pool?
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all alleles of a gene in a population
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What is an equation for the frequency of a gene in a population. assume dominat (p) and recessive (q)
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p + q = 1
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What is the Hardy-Weinberg Equation, and what assumptions does it have?
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q^2 + 2pq + p^2 = 1
1. Random mating, 2. no natural selection 3. large population 4. static population - no migrations, isolated 5. no new mutations introduced |
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What is the implication of the Hardy-Weinberg principle?
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genetic variability can persist indefinitely, unless other evolutionary forces act to remove it
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What is the coefficient of inbreeding?
What is the value for first cousins? |
probability that an individual is homozygous at a locus as a result of consanguinity of parents. 1/2 * coefficient of relationship
cousins 1/16 |
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The new risk of being homozygous for a particular disease becomes xx after consanguinity?
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1/16 * q for cousins
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What happens as a result of population bottleneck/founder effect?
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possibility for unusually high frequency of a particular allele of haplotype in a population
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Founders effect vs bottleneck effect
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founders - small numbers of ppl starting
bottleneck - population drops greatly and is being rebuilt |
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What is genetic drift?
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change in gene frequencies between generations b/c of chance differences between the gene frequencies in parental and offspring pop
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