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30 Cards in this Set

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  • Back
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_____ cells are predominatly found in the antrum and _________ cells are predominatly found in the fundus.
Gastrin cells are predominant in the antrum and parietal cells are predominant in the fundus.
282
What are the 3 main stimuli of acid secretion?
Ach, histamine, gastrin
282
Gastrin stimulates the ECL cells to secrete histamine that stimulates ______ cells. arietal cells are also activated by ______ to increase expression of _______ that increases ______secretion.
Gastrin stimulates the ECL cells to secrese histamine that stimulates PARIETAL cells. Parietal cells are also activated by GASTRIN to increase the expression of the H,K ATPase that increases ACID secretion.
282
This type of drug acts by inhibiting M1 and M3 receptors on ECL cells and Parietal cells, respectively.
muscarinic antagonists block M1 receptors in ECL cells and M3 receptors in parietal cells.
282
This type of drug inhibits the ability of the ECL cell to stimulate acid secretion by interfering with the _____ receptor.
H2 blocker inhibits the ability of the ECL cell to stimulate acid secretion by interfering with the parietal H2 receptor.
282
The most direct way of inhibiting acid secretion is by using ___ drugs which acts on this enzyme.
the most direct way of inhibiting acid secretion is by using PROTON PUMP BLOCKERS which inhibit the H,K ATPase on parietal cells.
282
____________ acts by binding to the ulcer and increasing its healing. It may interfere with drug absorption in the stomach.
SUCRALFATE and BISMUTH bind to the ulcer base and provides physical protection. It allows HCO3- secretion to reestablish pH gradient in the mucus layer.
282
What hormone binds ECL cells and decreases acid secretion?
somatostatin
282
These type of drugs used to decrease pH in the stomach.
antacids….duh….jk. (I was instructed to make a question of every word)
282
____________, ___________, ___________, and ___________ are examples of H2 blockers and they act by (reversibly/irreversibly)
cimetedine, ranitidine, famotidine, nizatidine reversilbly block H2 receptors.
282
This H2 blocker is the only one that has many side effects which include potent inhibition of ______, _____ effects, and _____ renal excretion of creatinine.
CIMETIDINE is a potent inhibitor of P450, it has ANTIANDROGENIC effects and DECREASES renal excretion of creatinine. Other H2 blockers are relatively free of these effects.
282
_________ and _________ (reversibly/irreversibly) inhibit the H/K ATPase in the stomach _______cells.
OMEprazole and LANSOprazole irreversibly inhibit the H/K ATPase in stomach parietal cells
282
Proton pump inhibitors are indicated for peptic ulcer, ________, _______, and _________ syndrome
peptic ulcer, gastritis, esophageal reflux, and Zollinger-Ellison syndrome
282
T/F: Bismuth and sucralfate allow HCO3- secretion.
True: bismuth and sucralfate bind to ulcer base and provide physical protection, and allow HCO3- secretion to reestablish pH gradient in the mucus layer=increased ulcer healing
282
T/F: misoprostol is a PGE2 analog and increases the production and secretion of gastric mucous barrier.
False: misoprostol is a PGE1 analog and it increases the production and secretion of gastric mucous barrier.
282
What are the 3 indications for misoprosol?
prevention of NSAID-induced peptic ulcers, maintains a PDA and used to induce labor
282
In what population is misoprostol contraindicated?
women of childbearing potential (abortifacient). It also casues diarrhea
282
Infliximab is ___________ against ______. It is a _____ cytokine
monoclonal antibody to TNFa, it is a PROINFLAMMATORY
282
The clinical indication for Infliximab is:
Crohn's, rheumatoid arthritis
282
What are the toxicities of Infliximab (3)
respiratory infection, fever, hypotension
282
This drug offers both anitbacterial action and anti-inflamatory effects. It is used for 2 inflammatory GI diseases ______ and _______.
sulfasalazine: combination of sulfapyridine (antibacterial) and mesalamine (anti-inflammatory effects). It is used for Ulcerative colitis and remission of Crohn's.
282
What are the side effects of the Sulfasalazine? ($)
Malaise, nausea, sulfonamide toxicity, reversible oligospermia
282
___________ is a powerful central-acting antiemetic. It acts by antagonizing the______ receptor.
Ondansetron: is a powerful antiemetic. It acts by antagonizing the 5-HT3 antagonist. Think: you will not vomit with ondansetron, so you can go on dancing.
282
What drug is used to treat vomitign postoperatively and in chemo theray as an antiemetic?
Ondansetron: is a powerful antiemetic. It acts by antagonizing the 5-HT3 antagonist. Think: you will not vomit with ondansetron, so you can go on dancing.
282
Headache and __________ are side effects of Oldanesetron
constipation (can't vomit or poop)
282
Antacid overuse can affect:_________, __________, or ______ excretion of other drugs by altering ______ and ______ pH or by delaying gastric _________.
Antacid overuse can affect ABSORPTION, BIOAVALABILITY, or URINARY EXCRETION of other drugs by altering gastric and urinary pH or by delaying gastric emptying.
282
Constipation and (hypo/hyper) phosphatemia is seen with overuse of ____________ what antacid?
aluminum hydroxide - Aluminimum amt. of feces
282
Magnesium hydroxide overuse = ___________
diarhea; Mg = Must go to the bathroom
282
Calicium carbonate= hypercalcemia and (increase/decreased) acid
causes hypercalcemia and increased acid.
282
T/F: hyperkalemia can be seen with AlOH, MgOH, CaCO2
False! hypokalemia
282