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15 Cards in this Set

  • Front
  • Back
SLE
Age
sex
race
type of disorder
Age: 20-45 (reproductive age)
Women > men (9:1)
Blacks > whites
Connective tissue disorder that mainly affects the blood, joints, skin, and kidneys Characterized by loss of self tolerance and production of auto-antibodies
SLE
mech of injury
Type II and III HPY rxns
SLE auto- antibodies
Anti-nuclear Antibody (95%)
Anti- dsDNA– unique to SLE
Anti-sm- (smith antigen)—diagnostic
Anti-Histone antibodies
Anti-phospholipid (lupus anticoagulant) (+) syphilis test, vasculopathy
SLE Sxs
Hypercoaguable state & thromboses
Spontaneous abortions
SLE lymph sxs
Painful lymphadenopathy
Splenomegaly
SLE MSK sxs
polyarthralgia and synovitis w/o joint deformity
SLE renal sxs
immune complex mediated nephritic syndrome
-diffuse proliferative glomerulonephritis (DPGN)
-death d/t renal failure
SLE hematologic sxs
(Type II HPY rxn)
-Autoimmune hemolytic anemia
-Thrombocytopenia
-Leukopenia
-neutropenia : leads to fungal and bacterial infections
-lymphopenia
SLE CV sxs
Leibam sacs endocarditis (sterile vegitations on mitral valve)
Fibrinous Pericarditis
SLE respiratory sxs
interstital fibrosis
Pleural effusion w/ friction rub
SLE pregnancy complications
complete heart block in newborns- cuased by IgG anti-SS-A (Ro) antibodies crossing the placenta
Recurrent spontaneous abortions- cuased by antiphospholipid antibodies
SLE skin sxs
d/t type III HPY
malar rash - triggered by sun exposure
Discoid skin lesions
maculopapular rash
blisters (bullae)
SLE serosal surfaces sxs
pericarditis
pleuralitis
pleural effusions
Lupus Erethematous cell
Neutrophil containing phagocytosed altered DNA
Not Specific for SLE
Lab resutls with SLE
Low complement C3/C4
low Hg
Low WBC

High C Reactive Protein
High ESR
+ direct coombs
High ANA