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15 Cards in this Set
- Front
- Back
SLE
Age sex race type of disorder |
Age: 20-45 (reproductive age)
Women > men (9:1) Blacks > whites Connective tissue disorder that mainly affects the blood, joints, skin, and kidneys Characterized by loss of self tolerance and production of auto-antibodies |
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SLE
mech of injury |
Type II and III HPY rxns
|
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SLE auto- antibodies
|
Anti-nuclear Antibody (95%)
Anti- dsDNA– unique to SLE Anti-sm- (smith antigen)—diagnostic Anti-Histone antibodies Anti-phospholipid (lupus anticoagulant) (+) syphilis test, vasculopathy |
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SLE Sxs
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Hypercoaguable state & thromboses
Spontaneous abortions |
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SLE lymph sxs
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Painful lymphadenopathy
Splenomegaly |
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SLE MSK sxs
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polyarthralgia and synovitis w/o joint deformity
|
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SLE renal sxs
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immune complex mediated nephritic syndrome
-diffuse proliferative glomerulonephritis (DPGN) -death d/t renal failure |
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SLE hematologic sxs
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(Type II HPY rxn)
-Autoimmune hemolytic anemia -Thrombocytopenia -Leukopenia -neutropenia : leads to fungal and bacterial infections -lymphopenia |
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SLE CV sxs
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Leibam sacs endocarditis (sterile vegitations on mitral valve)
Fibrinous Pericarditis |
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SLE respiratory sxs
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interstital fibrosis
Pleural effusion w/ friction rub |
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SLE pregnancy complications
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complete heart block in newborns- cuased by IgG anti-SS-A (Ro) antibodies crossing the placenta
Recurrent spontaneous abortions- cuased by antiphospholipid antibodies |
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SLE skin sxs
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d/t type III HPY
malar rash - triggered by sun exposure Discoid skin lesions maculopapular rash blisters (bullae) |
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SLE serosal surfaces sxs
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pericarditis
pleuralitis pleural effusions |
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Lupus Erethematous cell
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Neutrophil containing phagocytosed altered DNA
Not Specific for SLE |
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Lab resutls with SLE
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Low complement C3/C4
low Hg Low WBC High C Reactive Protein High ESR + direct coombs High ANA |