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15 Cards in this Set
- Front
- Back
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Levodopa
MOA AE Containdications |
MOA: increases DA precursor in CNS
AE: orthostatic hypotension, cardiac stimulation of both a and B receptors, dyskinesias, "on-off syndrome" Containdications: vit.B6/pyridoxine(increases peripheral conversion to DA), tricyclic antideprssants, (increase orthostatic hypotension), Antipsychotics (are DA antagonists), anticholinergics (slow gastric emptying --> derc abs of L-dopa), MAOI (incr effect of DA --> HTN) [PAAAM] |
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Carbidopa
MOA |
MOA: blocks AADC in periphery, increases Ldopa in CNS
does not cross BBB Given with Ldopa to reduce side effects |
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DA agonists
MOA AE Containdications |
1st LINE!!!!!!
Non-Ergot Derrived: Pramipexole [D2] (NEUROPROTECTIVE) / Ropinerole [D3] MOA: direct activation of DA-R Also used for Restless Leg syndrome (RLS) AE: nausea, dizziness, impulse control disorders, hallucinations -Less "on-off" -Less dyskinesias Ergot Derrived: Bromocriptine MOA: direct DA-R' activator |
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Amantadine
MOA AE |
MOA:incr. DA release from good neurons
Also blocks NMDA R's AE: mild and reversible hallucinations, confusion, nightmares, etc |
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Anticholinergic Drugs
MOA AE |
Trihexyphenidyl / benztropine
block unopposed cholinergic effects in BG --> decr. tremor AE: CNS: Confusion, delirium, somolence, hallucinations Peripheral: CYCLOPLEGIA, constipation, urinary retention |
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MAOB Inhibitors
MOA AE |
Selegiline / Rasalgeline (NEUROPROTECTIVE)
MOA: block degradation of DA AE: nausea, Dizziness Must keep a low dose |
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Digoxin
MOA: AE: Contraidications |
Use for: HF, A-fib, A-flutter, PAT
MOA: [cardiac glycoside] incr. contraction; incr. psym/decr. symp; incr. refractory period at AV node AE: arrhythmias, agitation/fatigue, yellow-green halo Contraindications: Amioderone, Beta-Blockers, CCB, Diuretics, Erythromycin, Quinidine, Verapimil, , V-fib, V-Tach, [ABCDEQ-3V] |
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Streptomycin
MOA AE |
MOA: binds to 30s ribosomal subunit; blocks protein sysnthesis; Bacteriocidal
AE: ototoxicity, vertigo, nephrotoxicity Given IM only |
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Rifampin
MOA AE Contraindications |
MOA: inhibits DNA-dependent RNA synthase; blocks RNA synthesis; Bacteriocidal
AE: rash, fever, flu-like symp. Red/Organge body fluids; INCR. P450 Contraindications: Anticoagulants, anti-fungals, Beta-Blockers, Contraceptives, HIV (PI, NNRTI) [AABC-H] RECALL: 5 Rs : RNA polymerase, Revs up p450, Resistance, Red-orange, Rash |
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Isonizide (INH)
MOA AE |
MOA: inhibits synthesis of myocolic acids; bacteriocidal
AE: Hepatotoxicity, Nephrotoxicity, B6 deficiency, DECR. P450 Containdications: Renal Failure, Liver Failure |
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Pyrazimide
AE |
MOA is unknown
AE: hepatotoxicity Hyperuricemia --> GOUT |
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Ethambutol
MOA AE |
inhibits Arabinosyl Transferase; Bacteriostatic
AE: Optic Neuritis, Hyperuricemia --> GOUT |
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Sulfyureas
MOA AE Contraindications |
Ends in -ride,-mide, -zide
MOA: incr. release of insulin, blocks K+ channel --> depol these are prodrugs that is converted to the active form in the LIVER, and excreted as an active metabolite in the KIDNEY AE: HYPOGLYCEMIA Contraindications: Liver failure, Renal Failure |
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Repaglinide/ Nateglinide
MOA |
MOA: Incr. Insulin Release
MOA is similar but diff from sulfyureas Short acting, Fast onset |
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Metformin
MOA AE Contraindications |
MOA: Decr. gluconeogenesis; incr. glycolysis; decr. glucagon, decr. GI abs of glucose
AE: lactic acidosis (glycolysis), metallic taste, GI effects Contraindications: Renal Failure, Liver Failure ** does not cause hypoglycemia |
