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7 Cards in this Set

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what are commonly known polyoma viruses?
BK, JC, KI, SV 40
structure and replication of polyomaviruses?
non enveloped dsDNA in circle; one strand encodes early T (transforming) antigens, other strand encodes late structural genes (capsid : VP1-3)
polyoma epidemiology?
ubiquitous and persistant, usually asympto, get it befroe 15 usually, initial infection in resp tract, virus persists in kidney
primary infection sxs?
usually asympto
what does it do in immuno compromised?
excreted in the urine of 40%,
pregnancy complications?
reactivates in pregnancy
two types that are infectious in ppl and describe the specefic disease caused by each.
BK (urethral stenosis in renal transplants, hemorrhagic cystitis in bone marrow transplants) and JC (progressive multifocal leukoencephalopathy, usually in AIDS, subacute demyleinating disease involving oligodendrocytes, multiple foci in white matter of cortex, impaired speech, vision, mentation; paralysis; death in 90% of cases) note all this only in immunocompromised; note KI detected by PCR in ppl but no disease associated yet