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12 Cards in this Set
- Front
- Back
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Describe the structure of Polio virus.
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ss+RNA
-Spherical -Acid stable |
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What is the Viropexis?
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Endocytic property that facillitates the energy dependent process of penetration and uncoating.
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T/F
99% of polio infx are subclinical. |
True and only a minority of cases develop into aseptic meningitis, even fewer into paralytic polio.
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What is Progressive Post-Poliomyelitis muscle atropy? What is this do to?
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-25-40% of earlier infxs suffer additional muscular degeneration - yrs later.
-Not due to persistence of virus, rather effect of aging. |
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Where is the site of the primary replication of polio? Primary viremia?
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-Oropharynx mucosa, tonsils and lymph nodes of neck.
-Viremia in Peyers Patches and mesenteric lymph nodes. |
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Two ways paralysis can occur?
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-direct destruction of neurons by virus or
-edema induced damage. |
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3 ways we see polio infx in US.
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-Immunocompromised vacinnee
-imported -grandparent with dec. imm., changes recently vaccinized baby. |
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3 advantages of IPV
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-IPV can be incorporated with multiple vaccines.
-excludes potential for mutations. -Can be used in immcompromised patients. -Reduces spread of live polio. |
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3 disadvantage of IPV
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-Repeat boosters are required.
-No local intestinal immunity. -Expensive |
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3 advantages to OPV.
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-Confers both humoral and intestinal imm.
-Imm may be life long. -Quickly induces Abs. -Oral -Inexpensive |
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3 disadvantages of OPV.
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-Virus might mutate.
-Vaccine can spread virus to others and environment. -Can't give to immunosuppressed. |
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Starting from the 70s, tell the story of the polio vaccine.
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OPV was implemented in the 70s and after several cases of polio each year, IPV was re-implemented in 2000.
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