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20 Cards in this Set

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  • Back
What type of hypersensitivity is contact dermatitis? What type of molecule usually causes it?
Type IV delayed (poison ivy).
Protein w/ hapten
Why does type IV take so long?
B/c the already sensitized Th1 cell has to find its way w/o chemoattractants.
Mediators of type IV hypersensitivity?
TH1 and sometimes CD8 CTL
Mechanism of Type IV
Allergen w/ hapten taken up by APCs, taken to nodes. TH1 activated. Second exposure, Th1 is circulating and finds allergen, releases pro-inflammatory cytokines.
How would you involve CD8 cells in type IV?
Supply a lipid Ag like poison ivy that can get into normal cells and be expressed on MHC1
Example of type II hypersensitivity?
X-reactive ab from mycoplasma binding to RBC surface Ag.
What is the mediator of type II?
IgM or IgG antibody.
Example of type III hypersensitivity?
Serum sickness (administer high dose drug and immune complexes form).
What is the Arthus reaction?
It is a type III hypersensitivity reaction to a subQ injection (like allergy test).
Mediators of type III?
IgG ab directed at allergen. C3a and C5a anaphylotoxins released.
Unique thing about type III?
It causes hemorrhage or petechiae in the skin due to inflammation of bvs.
Signs of type III hypersensitivity?
Vasculitis (rash), glomerulonephritis and arthritis.
Example of type I hypersensitivity?
Atopic Dermatitis (remember atopy means lots of IgE).
Mechanism of Atopic Dermatitis?
Keratinocytes are aggravated by allergen or trauma, release inflammatory cytokines. Th2 attracted to produce IgE.
Main problem in X-linked agammaglobulinemia? What would you find in this patient's serum?
The gene coding btk kinase is on X-chromosome. It is required for B cell differentiation.
No IgG, IgA or IgM. Also low B cells.
What infections are patient's w/ X-linked agammaglobulinemia susceptible to? What complication results?
Pyogenic extracellular bacteria
Bronchiectasis from continuous neutrophil infiltration
Genetic defect in X-linked SCID? What infections are they predisposed to?
y chain of IL receptor. Initially thought to be IL-2 problem but really IL-7 problem.
Severe opportunistic infections.
Are B cells high or low w/ X-linked SCID?
Normal but they can't function properly w/o T cell interaction.
What test is used for assessment of complement MAC system?
CH50 test (double immunodiffusion).
What infections are you susceptible to if you have IFN-y deficiency?
MTB, leishmaniasis, salmonella or anything intracellular. No Th1 response.