Pod Autoimmune Mechs Sle

Front 1

When is an autoreactive T cell a good thing?

Back 1

1. Suppress excessive autologous cells
2. Monitor potential autologous malignancies
3. Can suppress T cell activity

Front 2

When is an autoreactive B cell a good thing?

Back 2

1. Aid in autoantigen presentation to baby T cells in the thymus, contributing to neg deletion
2. Can pick up IgG by the tail and carry it's immune complex to a T cell
3. Maintenance of the antibody pool as auto-conditions change.

Front 3

Disease where the body makes antibodies to its platelets?

Back 3

Idiopathic Thrombocytopenic Purpura

Front 4

Disease where mitochondrial markers in bile ducts become the victim of T cells?

Back 4

Primary Biliary Cirrhosis

Front 5

Female to male ratio of SLE?

Back 5

5:1, with black females predominant.

Front 6

2 limitations of SLE diagnostic criteria

Back 6

1. Patient may not meet the criteria but benefit from treatment
2. Patient may meet 4 criteria and still not have SLE

Front 7

11 SLE criteria

Back 7

1. Malar Rash
2. Discoid Rash
3. Oral Ulcers
4. Arthritis
5. Serositis
6. Renal proteinuria or casts
7. Neuro seizures or psychosis
8. Photosensitivity
9. Hemato - penia
10. Immuno disorder
11. ANA

Front 8

What kind of autoantibodies do SLE patients typically produce?

Back 8

Anti-nuclear antibodies, which are also found in 1 out of every 10 normal peeps. But SLE ANAs are pathogenic, unregulatable.

Front 9

Role of Class II HLA genes in SLE?

Back 9

-The kind and style of autoantibodies
-T and B cell recognition
-Age of onset
-Clinical presentation

Front 10

Role of Class III HLA genes in SLE?

Back 10

Predisposition in certain ethnic groups

Front 11

Environmental causes of SLE

Back 11

1. UV light!
2. Hair dyes/organics
3. Drug-induced: can be reversed by stopping the medication
4. Viral

Front 12

Metabolism of sex hormones in SLE patients?

Back 12

Abnormal. Both genders will metabolize testosterone more quickly and estrogen less quickly.
-"Castrated" females are protected
-"Castrated" males are more susceptible.

Front 13

Neuroendocrine role in SLE?

Back 13

Prolactin up, ADH up, everything slightly skewed

Front 14

Cellular (T and B cell) defects in SLE?

Back 14

Increased receptor expression and signaling sensitivity, with impaired tolerance and apoptosis, ridiculous amounts of antibody production