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20 Cards in this Set
- Front
- Back
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What are the different steps of platelet plug formation?
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1. Injury
2. Adhesion 3. Aggregation |
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What are the first factors to bind together upon endothelial damage?
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Circulating vWF binds to the collagen within the vessel wall
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What is the molecule that platelets bind to in the wall of a vessel when injury occurs?
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to vWF via GpIb
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What is released by platelets to assist in the coagulation cascade?
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Calcium
ADP |
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What is the action of ADP on platelets?
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Helps platelets to adhere to the endothelium by inducing GpIIb/IIIa expression at the platelet surface
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What occurs during the aggregation stage of platelet plug formation?
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Fibrinogen binds GpIIb/IIIa receptors and links factors
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What are pro-aggregation factors?
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TXA2
Decreased blood flow Increased platelet aggregation |
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What are anti-aggregation factors?
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PGI2, NO
Increased blood flow Decreased platelet aggregation |
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What is the mechanism of clopidogrel?
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Irreversable blockage of the ADP receptor, inhibiting platelet aggregation
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What is the mechanism of ticlopidine?
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Irreversible blockage of the ADP receptor, inhibiting platelet aggregation
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What is the mechanism of abciximab?
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Direct inhibition of GpIIb/IIIa; inhibition of fibrinogen binding to platelets
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What syndrome is deficient in GpIb?
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Bernard Soulier syndrome
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What syndrome is deficient in GpIIb/IIIa?
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Glanzmann's thrombasthenia
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What factors are released by platelets during thrombogenesis?
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vWF
Fibrinogen TXA2 |
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What are the factors related to thrombogenesis that are contained within vascular endothelial cells?
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vWF
Thromboplastin tPA, PGI2 |
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With respect to ESR, what are causes of RBC aggregation?
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Acute-phase reactants within plasma
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What are causes of increased ESR?
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Infections
AI diseases Malignant neoplasma UC Pregnancy |
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What are some autoimmune diseases that have increased ESR?
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SLE
RA Temporal arteritis |
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What are some causes of decreased ESR?
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Polycythemia
Sickle cell anemia CHF Microcytosis Hypofibrinogenemia |
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What is the mechanism of asprin?
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Inhibition of cyclooxygenas--> decreased TXA2 synthesis
In this way asprin inhibits clotting (TXA2 is pro-aggregation factor) |
