Platelet Production, Function, Destruction, Structure

Front 1

3 stages of hemostasis

Back 1

adhesion, activation, and aggregation

Front 2

Where are platelets produced

Back 2

in the bone marrow

Front 3

Whatis the precursor cell for platelets

Back 3

megakaryote

Front 4

What is the cytokine that regulate sthe maturation of megakaryotes and production of platelets

Back 4

thrombopoietin (TPO)

Front 5

Where is Thrombopoietin (TPO) produced

Back 5

liver, kidney, spleen, maybe marrow

Front 6

How does TPO regulate the amount of platelets produced

Back 6

it binds to the platelets, so the more platelets, less TPO in plasma.

Less platelets, more TPO circulating and stimulates platelet production

Front 7

vWF anitgen can be found on what cell

Back 7

megakartoblast

Front 8

What is charactoristic of cellular changes as megakaryoblasts mature into megakaryocytes in the bone marrow

Back 8

nuclear divison without cytoplasmic division

Front 9

What cell contains hemosiderin

Back 9

histocyte

Front 10

What is the lasrgest cell in the bone marrow

Back 10

megakaryocyte

Front 11

Normal platelets circulate for about how long

Back 11

10 days

Front 12

Where are spare platelets stored

Back 12

in the spleen

Front 13

Aspirin affects platelets function by interfering with platelets metabolism of

Back 13

prostaglandins

Front 14

A combination of increased capillary fragility and prlonged bleeding time suggests a deficiency of

Back 14

platelets

Front 15

platelet activity can be affected by

Back 15

aspirin

Front 16

alpha granules are found on the platelet in the

Back 16

organelle zone

Front 17

Where are glycoproteins Ib/IX and llb/llla found on the platelet

Back 17

peripheral zone

Front 18

Where and how are platletes destroyed

Back 18

by phagocytosis in the spleen and liver

Front 19

platelet adhesion refers to __________ attaching to ________

Back 19

platelets, collagen (tissue)

Front 20

PLatelet aggregation refers to ________ attaching to ______

Back 20

Platelets, platelets

Front 21

vWF binds to glyocoprotein ________

Back 21

Ib

Front 22

Where is vWF sythesized (2)

Back 22

megakaryocytes and endothelial cells

Front 23

Which factor is VWF noncovalently linked to in the plasma

Back 23

F-VIII

Front 24

What is contined in the dense bodies of platelets (4)

Back 24

ADP

ATP

Ca++

Serotonin

Front 25

Where is the VWF found in the platlet

Back 25

Alpha granules

Front 26

Where is FV and FXI found in the platelet

Back 26

alpha granues

Front 27

What is synthesized in the dense tubular system of platelets

Back 27

prostaglandin

Thromboxane A2

Front 28

What is stored in the dense tubular system of platelets

Back 28

Ca++

Front 29

Arachidonic acid is important in platelet

Back 29

activation

Front 30

which enzyme does aspirin inactivate

Back 30

Cyclo-oxygenase

Front 31

Where does vWF get synthesized

Back 31

endothelial cells

Front 32

What is the enzyme that cleaves vWF into smaller units

Back 32

ADAMTS 13

Front 33

What is the role of the enzyme ADAMST 13

Back 33

cleaves vWF into smaller units

Front 34

What is the platelet receptor for fibrinogen

Back 34

GP IIb/IIIa

Front 35

What is the platelet receptor for vWF

Back 35

GP Ib

Front 36

Where are old platelets destroyed

Back 36

the spleen

Front 37

What forms the bridge bwtn platelets and collagen

Back 37

vWF

Front 38

The process by which th nucleus divides while the cytoplasm grows but does not divide is

Back 38

endomitosis

Front 39

The series of channels that leads from the surface to the center of the platelet. Releases granular contents after activation

Back 39

open cannicular system

Front 40

What is the membrane phospholipid that changes orientation and binds to factors V and VII

Back 40

PF3

Front 41

This is contained in endothelial cells and other cells, is released duting injury and initiates the extrinsic coag pathway

Back 41

tissue factor