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12 Cards in this Set
- Front
- Back
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Who produces TPO?
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liver (kidney, marrow stroma, smc)
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Number for thrombocytopenia?
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150,000
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Difference btwn acute and chronic ITP?
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acute (children, post viral, resolves 6-12mths) chronic (adult, ass w/other autimmune, lasts for years)
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Classic pentad for TTP?
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fevers, renal failure, neuro symptoms, hemolytic anemia, thrombocytopenia
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Difference btwn familial and spordic TTP?
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familial is defective or absent adamts13; sporadic is ab mediated
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Defect in Glanzmann thrombasthenia?
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deficient GpIIb/IIIa (fibrinogen receptor)
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Defect in Bernard Soulier syndrome?
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deficient GpIb (vWF receptor)
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Defect in storage pool dz?
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abnormal ADP/serotonin release (stored in dense bodies)
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Defect in Grey Platelet syndrome/
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abnormal secretion of alpha granule proteins (vWF and fibrinogen)
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How does clopidogrel work/
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blocks ADP receptor on platelets
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Name some aqcuired qualitative platelet d/o causes?
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renal failure, cardpulm bypass, drugs, myeloprolif/dysplast d/o
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Which drugs are ass w/platelet dysfxn?
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asa, beta lactam abx, nsaids
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