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20 Cards in this Set
- Front
- Back
Albumin
Fxn Sugars? |
most abundant in the vascular system by maintaining the pressure in arteries
main determinant of colloid NO SUGAR PRESENT |
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Protein Degradation
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1. Removal of Sialic Acid (sugar )via endothelial neuramindase
2. Hepatocytes have receptors for asialoglycoproteins and the liver degrades them while liberating an AA |
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Plasma
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contains fibrnongen that allows for clotting
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Serum
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does not contain fibrnongen, no clotting occurs
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Albumin Fxns
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Maintains oncotic pressure
Transport of FA, Bilirubin Drug Transport |
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Hypoalbuminemia
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albumin decreases, water leaves & goes into interstitial space.
which leads to edema |
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Causes of Hypoalbuminemia
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reduced synthesis due to IL6/stress
altered distribution due to inflammation & lymph clearance increased catabolism burns, renal disease, GI loss |
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Inherited Hypoalbuminemia
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rare disease
pt will have low albumin but will be able to self correct |
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Hyperalbuminemia
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dehydration
excessive stasis during venipuncture |
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Acute Phase Proteins
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are needed for immune response
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Binding Proteins
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Prealbumin
Albumin Retinol BP Thyroxine Binding Globulin Cortisol Binding Globulin or Transcortin |
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Prealbumin
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binds to retinol & thyroid hormones
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Albumin
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maintains osmotic pressure
binds protein for multiple substances |
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Retinol BP
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retinol transport
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Thyroid
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binds T3 and T4
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Cortisol binding globulin
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binds glucocorticoids
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Acute Phase Proteins
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needed for immune reponse
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alpha feta protein
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only present in fetus
in adults = liver cancer High in fetus = neural tube defect |
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Ceruloplasmin
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used to detect Wilsons' disease
transports copper Low levels of Ceurloplasmin = more free copper to floate around can lead to Keyser Flescher Rings |
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Beta two microglobulin
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detects nephrotic syndrome
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