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20 Cards in this Set

  • Front
  • Back
Albumin
Fxn
Sugars?
most abundant in the vascular system by maintaining the pressure in arteries
main determinant of colloid
NO SUGAR PRESENT
Protein Degradation
1. Removal of Sialic Acid (sugar )via endothelial neuramindase

2. Hepatocytes have receptors for asialoglycoproteins and the liver degrades them while liberating an AA
Plasma
contains fibrnongen that allows for clotting
Serum
does not contain fibrnongen, no clotting occurs
Albumin Fxns
Maintains oncotic pressure
Transport of FA, Bilirubin
Drug Transport
Hypoalbuminemia
albumin decreases, water leaves & goes into interstitial space.
which leads to edema
Causes of Hypoalbuminemia
reduced synthesis due to IL6/stress
altered distribution due to inflammation & lymph clearance
increased catabolism
burns, renal disease, GI loss
Inherited Hypoalbuminemia
rare disease
pt will have low albumin but will be able to self correct
Hyperalbuminemia
dehydration
excessive stasis during venipuncture
Acute Phase Proteins
are needed for immune response
Binding Proteins
Prealbumin
Albumin
Retinol BP
Thyroxine Binding Globulin
Cortisol Binding Globulin or Transcortin
Prealbumin
binds to retinol & thyroid hormones
Albumin
maintains osmotic pressure
binds protein for multiple substances
Retinol BP
retinol transport
Thyroid
binds T3 and T4
Cortisol binding globulin
binds glucocorticoids
Acute Phase Proteins
needed for immune reponse
alpha feta protein
only present in fetus
in adults = liver cancer
High in fetus = neural tube defect
Ceruloplasmin
used to detect Wilsons' disease
transports copper
Low levels of Ceurloplasmin = more free copper to floate around
can lead to Keyser Flescher Rings
Beta two microglobulin
detects nephrotic syndrome