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9 Cards in this Set
- Front
- Back
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factors that impact post-abx effect (PAE)
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-organism
-duration of drug exposure -use with beta-lactam abx -higher drug [] = longer PAE |
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wat are stages in drug development PK is involved in?
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PK and drug disposition
preclinical toxicology and IND app clinical trials phars 1,2,3 |
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wat is reduced in geriatric metabolism?
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oxidation, reducation, hydrolysis (phase1 rxns)
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TDM for vanco
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Vanco doesn' t have a post-abx effect (PAE) and is bactericidal except for enterococcus (static)
-want higher troughs |
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goal vanco troughs for serious infxns:
-endocarditis, pneumonia, osteomyelitis, meningeitis |
15-20mcg / mL
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goal vanco troughs for less serious infxns:
- UTIs, uncomplicated cellulitis |
10-15 mcg / mL
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definition of first order elimination
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the amount of drug eliminated per hr decreases as the [] decreases; but fraction of drug eliminated per hr is constant
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when to draw trough?
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30mins before 3rd dose
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slope will be falsely _____ if pk measured too early
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falsely elevated
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