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Pituitary gland controlled by?

*Hypothalamus part of the CNS.


CNS controls pituitary gland.

Hypothalamus and Pituitary glad:Functions

Hormones: Criticaltropin Releasing Hormone (CRH) + stimulates anterior pituitary to release ACTH = stimulation of adrenal cortex to release cortisol = Negative beedback as cortisol levels ^

Anterior pituitary drugs

Coyntropin


Octreotide


Somatropin


Somatrem

Posterior pituitary drugs

Desmopressin


Vasopressin

Uses of Pituitary drugs

. Replacement therapy


. Produce a specific hormone response


. Determining hyper/hypo function of a specific hormonal function

A.P. drug; Cosyntropin (is ACTH): MOA

Stimulates release of cortisol from adrenal cortex.


Aldasterone effects.

A.P. drug; Cosyntropin: INDICATIONS

> Anti-inflammatory effect


> Promotes renal retention of sodium; may result in edema and htn

A.P. drug; Somatropin, Somatrem: INDICATIONS

> Recombinant made growth hormone


> Stimulates skeletal growth and patience with deficient GH

A.P. drug; Octreotide: INDICATION

Reduces severe diarrhea flushing and potentially severe hypotension due to a carcinoid crisis

A.P drug Octreotide: Adverse Effect

> Carcinoid tumors secrete VIP (Vasoactive Intestinal Polypeptide)


> VIP causes profuse watery diarrhea

P.P drug; Vasopressin: INDICATIONS

Can be used in treatment of diabetes insipidus


VASOPRESIN: powerful vasoconstrictor used for hypertensive emergencies, GI bleeding, and pulseless cardiac arrest


DESMOPRESSIN: used for dose dependent treatment of blood disorders; also used for nocturnal enuresis