Pip

Front 1

Where is this most commonly found?

Back 1

This is a Chordoma. They are found at the distal and proximal ends of the spinal chord.

Front 2

Stains to diff this from chondrosarc?

Back 2

EMA, CK positive in this (chordoma). S-100 positive in both.

Front 3

What is this?

Back 3

Chordoma

Front 4

What is this?

Back 4

Giant cell fibroblastoma

Front 5

What is the juvenile equivalent to DFSP?

Back 5

Giant cell fibroblastoma

Front 6

What cytogenetic abnormality is seen in both DFSP and Giant cell fibroblastoma?

Back 6

t(17;22) PDGFb-COL1a1(type 1 collagen)

Front 7

What IP stain is positive in Giant cell fibroblastoma?

Back 7

CD34, it is considered the juvenile equivalent to DFSP which is also CD34 +. Both show t(17;22)

Front 8

Testicle - what is it?

Back 8

Sertoli cell tumor
-classically associated with gynecomastia although infrequent

Front 9

What testicular tumor is associated with Puetz-Jegher's syndrome?

Back 9

A tumor that is intermediate between large cell calcifying sertoli cell tumor and sex cord stromal tumor with annular tubules.

Front 10

What ovarian tumor is associated with Puetz Jegher's syndrome?

Back 10

Sex cord stromal tumor with annular tubules

Front 11

Ovarian tumor, what is it?

Back 11

Sertoli cell tumor

Front 12

What age group show the peak frequency in sertoli cell tumor?

Back 12

35-50 y/o (mean 45)

Front 13

What feature of well-differentiated sertoli cell tumors is unique among testicular neoplasms?

Back 13

tubule formation

Front 14

What histologic features are most helpful differentiating a sertoli tumor without tubules from a seminoma?

Back 14

Sertoli- small round nuclei
Seminoma- larger square nuclei (irregular contours)

A subpopulation of Sertoli have cytoplasmic vacuolization (diagnostic)

Front 15

What syndrome is associated with bilateral large cell calcifying sertoli tumors of the testicle?

Back 15

Carney's syndrome - Cardiac and cutaneous (eyelid) myxomas, myxoid mammary fibroadenomas, adrenal nodular dysplasia with cushings, large cell calcifying sertoli tumor

Front 16

Testicular tumor that presents with gynecomastia without virilism?

with virilism?

Back 16

Sertoli cell tumor (33%)

Leydig cell tumor

Front 17

Large cell calcifying sertoli cell tumor unlike sertoli tumor (NOS) is negative for EMA and is notably strongly positive for what?

Back 17

S-100

Sertoli (NOS) is weakly positive

Front 18

What are the two most important stains for differentiating sertoli cell tumor (NOS) from seminoma. (one positive, one negative)

Back 18

PLAP (and CD117)- positive in seminoma

Inhibin- positive in sertoli cell tumor

Front 19

T/F Chordomas follow a benign course and rarely recur.

Back 19

False
There are usually repeated episodes of recurrence and metastases is common.

Front 20

What tumor is associated with androgen insensitivity syndrome.

Back 20

Sertoli cell adenoma
In undecended testis, likely just hyperplasia but can be very large.

Front 21

kidney tumor. Sensitive IP stain?

Back 21

This is a metanephric adenoma. It is thought to be related to Wilm's tumor; both are WT1 positive

Front 22

Lung; what is this?

Back 22

Silicotic nodule/Silicosis

Front 23

When silicotic nodules expand and become confluent, what is this disease entity called?

Back 23

Progressive massive fibrosis (complicated silicosis)

Front 24

Nodules in silicosis are distributed diffusely but tend to be most numerous where?

Back 24

Upper lobes

Front 25

What causes this?

Back 25

This is silicosis caused by inhalation of fine particles of silica most often in the form of quartz, tridymite or cristbalite.

Front 26

What is the key architectural feature of litoral cell angioma?

Back 26

Papillary structures

Front 27

What does litoral cell angioma stain positive for that other vascular tumors do not stain for?

Back 27

CD21