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10 Cards in this Set
- Front
- Back
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Diseases caused by Picornaviruses
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list
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General Structure of picornaviruses
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- Small, non-enveloped viruses
- Positive polarity single-stranded RNA genome - naked icosahedral capsid, high environmental stability |
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Replication strategy of picornaviruses
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answer
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Antiviral drug targets for picornaviruses
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list
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Genome structure of Picornaviruses
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- (+) Polarity ssRNA
- 5' UTR (Untranslated region) contain an IRES (internal ribosome entry site) - both 5' and 3' UTRs contain (-) and (+) polarity RNA promoters - polyprotein coding - Poly-adenylate tail similar to cellular mRNAs |
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Enteroviruses
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- Echoviruses
- Coxsackievirus A and B - Poliovirus |
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Echoviruses disease
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- respiratory infections
- meningitis - carditis - paralysis |
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Coxsackievirus diseases
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- A; meningitis, herpangina, hand-foot-and-mouth disease
- B; Meningitis, myocarditis, maybe diabetes |
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Poliovirus disease
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- paralytic poliomyelitis
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Immune resonse to rhinoviruses
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- IgA in nasal secretions most effective part of immune response
- immunity wanes after 2 years - >100 antigenically distinct serotypes |
