Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/5

Click to flip

5 Cards in this Set

  • Front
  • Back
What does carbonic anhydrase do/
It catalyzes the formation of H2CO3 and drugs that inhibit CA depress both secretion of acid by the proximal tubules and the reactions which depend on it.
What is the difference between H+ secretion in the PCT and DCT?
In the DCT and collecting ducts, H+ secretion is relatively independent of sodium in the tubular lumen. In this part of the tubule, most H+ is secreted by an ATP driven proton pump.
How does aldosterone act on the proton pump?
It acts on it to increase distal H+ secretion. The I cells in this part of the renal tubule secrete acid and like the parietal cells in the stomach, contain abundant carbonic anhydrase and numerous tubulovesicular structures.
What is Band 3?
The I cells contain Babd 3, an anion exchange protein, in their basolateral cell membranes and this protein may function as a Cl-HCO3 exchanger for the transport of HCO3 to the interstitial fluid.
What is limiting pH?
The maximal H+ gradient against which the transport mechanisms can secrete in humans corresponds to a urine pH of about 4.5, ie, an H+ concentration in the urine that is 1,000 times the concentration in plasma(pH 4.5 is thus the limiting pH).