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27 Cards in this Set
- Front
- Back
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What starts puberty?
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maturation of the hypothalamic pituitary gondal axis
hypothalamus activates releasing GnRH |
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What hormones are active in the fetus?
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FSH and LH, used to differentiate sex organs
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why does FSH and LH decrease right before birth?
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the mom's estrogen/ progesterone gives negative feedback
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What is the first stage of female puberty?
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thelarche (breast development)
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what hormone causes thelarche?
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estrogen (promotes mammillary glad development)
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what is the 2nd stage of female development?
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pubarche (pubic hair)
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What is the 3rd stage of female development?
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menarche
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why are the 1st few menarche cycles non ovulatory?
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you need to recruit the secondary follicles, so they take a long time to grow
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what is the start of puberty for boys?
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testicular increase,
pubic hair penile enlargement |
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what is the result of gonadarche?
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production of testo, and the rest of male development
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What to hormones promote the growth spurt?
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GH and IGF-1
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when do boys grow, vs women?
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women grow taller first
boys grow taller later. |
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how much more lean body mass do men have than women
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men have 1.5X
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when does adrenarche occur?
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this normally occurs arond 8 years of age (adrenal androgen production)
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what is percocius puberty?
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this is developing secondary sex characteristics before normal age (females 7)
(males 9) |
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what are the biggest side effects of percocious puberty?
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short stature.
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what are the two types of precocious puberty?
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GnRH dependent (central)
Godnadotropin-independent |
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What causes GnRH dependent central precocious puberty?
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idiopathic
CNS tumors GnRH |
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what causes gonadotropin independent precocious puberty.
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boys- testicular tumors, hCG tumors, androgen tumors
women- ovarian disorder, estrogen tumors |
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what is constitutional delayed puberty?
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normal puberty, just occurs later (in general, kids are taller)
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What is Kallmans syndrome?
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hypogonadotropic hypogonadoism, GnRH does get a good pulsatile release of gonadotrpins
Tx- testosterone |
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what is tuners syndrome?
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hypergonadotropic hypogonadism
XO kid, non functional gonads, so no negative feedback of estrogen/progesterone VERY high FSH/LH Tx- sex steroids |
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do people have pubic hair in tuners syndrome?
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yes they do, but ONLY due to adrenergy
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How do you tell constitutional delay vs/ hypogonasim?
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measure DHEA (an adrenal roid)
IF low- constitutional delay |
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What is the major determinant of timing of puberty?
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genetic
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what is the weight required to initiate puberty?
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47kg
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how does body fact affect puberty start?
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fat people have puberty sooner
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