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8 Cards in this Set
- Front
- Back
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Tetrodotoxin (TTX)
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blocks voltage-sensitive Na channels so it abolish action potentials and acts as a neurotoxin
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Lidocaine
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block voltage-sensitive Na channels and is used as a common local anesthetic and antiarrhythmic drug
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Digitalis / Digitoxin / oubain
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Na/K ATPase blockers. Causes an increase in calcium because blocks the Na/Ca exchanger. This leads to a + ionotropic effect, increasing contractility (SV)
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Botulinus toxin (Botox)
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blocks release of ACh from presynaptic terminals and therefore total blockage of neuromuscular junction can occur
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Curare
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competes with ACh for receptors on motor end plate causing a decreased EPP. at max doses can cause paralysis of respiratory muscles and death
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Neostigmine
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inhibits acetylcholinesterase. this prolongs and enhances action of ACh at muscle end plate
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Hemicholinium
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blocks uptake of choline into presynaptic terminal and depletes ACh stores from presynaptic terminal
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Atropine
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lowers parasympathetic activity of all muscles and glands regulated by the parasympathetic nervous system, particularly of the heart (leads to increased firing at the SA node)
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