Physiology I

Front 1

net transport of transfer of matter from one place to another by random molecular movements

Back 1

Diffusion; dependent on Brownian motion

Front 2

Properties of Diffusion

Back 2

temperature dependent
time independent at equilibrium

Front 3

Characteristics of Diffusion

Back 3

Slow, only good over short distances, often confused with convection

Front 4

Diffusion Equation

Back 4

(ΔX)^2 = 2Dt

distance squared equals 2 times the product of the diffusion coefficient and the time

Front 5

diffusion coefficient (D)

Back 5

D = kT/(6πrη)
increases with increased temp
decreases with increased radius of viscosity

Front 6

pneumonia and pulmonary edema effects on diffusion

Back 6

fluid fills the lungs increasing viscosity of medium through with the molecules flow and decreasing the rate of diffusion of the molecules

Front 7

Fick's Law

Back 7

J=-D(ΔC/ΔX)
Rate of flux equals the diffusion coefficient times the concentration gradient divided by the distance
UNITS = mole/hr * square cm

Front 8

Partition Coefficient

Back 8

Index for Lipid Solubility of Molecules as they cross the plasma membrane: eq. concentration in olive oil/ eq. concentration in H2O (must be greater than 1 to be lipid soluble)

Front 9

Permebility Coefficient

Back 9

P=βD/ΔX which simplifies the flux equation to J=-PΔC

Front 10

carrier mediated processes only capable of net transfer of a substance from a region of higher concentration to one of lower concentration until eq. is reached

Back 10

Facilitated diffusion
which shows saturation kinetics (Vmax and Km), structural specificity, Competitive Inhibition, MUCH faster than diffusion

Front 11

Types of Channel Gating

Back 11

1)Chemical, ligand- cAMP,ACH
2)Voltage
3)Intracellular ions-pH,Ca
4)Mechanical change-hair cells, pressure sensors

Front 12

ungated channels for single file diffusion of H2O

Back 12

aquaporins

Front 13

action of oubain binding

Back 13

prohibits K+ binding to the outside of Na/K ATPase

Front 14

short term regulation of Na/K ATPase

Back 14

changes in intracellular Na+; concentration of sodium inside the cell is below the Km for Na/K ATPase

Front 15

long term regulation of Na/K ATPase

Back 15

synthesis and degradation of the pump molecule; primarily through degradation

Front 16

Method of glucose absorption from the bowel

Back 16

sodium glucose symport
secondary active transport

Front 17

sodium/a.a. transport

Back 17

symport method of secondary ective transport occuring in muscle and liver

Front 18

pressure you apply to counter the hydrolic pressure moving water from one side of the plasma membrane to the other

Back 18

osmotic pressure

Front 19

Van't Hoffs Law

Back 19

Π = RT(C2-C1)

Front 20

index of solute permeability relative to that of water

Back 20

reflection coefficient
1-totally reflected
<1-penetrates membrane

Front 21

mechanoreceptor that rapidly responds to vibration

Back 21

Pacinian Corpuscle

Front 22

transient receptor potential ion channel sensitive to cold temperature

Back 22

TRPM8
activated by cold and menthol

Front 23

TRP ion channel sensitive to noxious heat

Back 23

TRPV1
activated by heat or capacin

Front 24

TRP channel that may be important in inflammatory pain

Back 24

TRPA1
sensitive to pungent chemicals