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32 Cards in this Set
- Front
- Back
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What stimulates the A. pit to make LH/FSH?
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Hypothalamus' GnRH
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Describe the structure of LH/FSH by their units?
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alpha - same in both
beta - differs |
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LH acts on what cells of the testes? to do what?
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on leydig cells to make testosterone
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FSH acts on what cells of the testes? to do what?
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sertoli, to make INHIBIN
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what doesINHIBIN do?
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inhibits A. Pit
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How does testostertone regulate itself?
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it inhibits Hypothalamus and A. Pit, thereby inhibiting LH/FSH release
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Where is the earliest peak of gonadotropins?
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2nd trimester, because the regulatory axis has not yet developed
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what happens to gonadotrope receptors ( of the ant pit) in puberty?
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less sensitive to test/estrogen feedback (so HIGHER)
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What is 5 alpha recutase?
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makes testosterone into DHT
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what is the promoter where androgen recpetors bind?
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HRE
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Give some examples of continus action of androgens
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Spermatogenesis,
secondary sex organ devo bone maturation/anablosim thicken larynx thick/darker skin |
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What is the non-contiunous androgen action?
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sexual differentiation
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3 sexual deteminants (3g's)
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genetics
gonads genitalia |
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What does a Y chromosome do for a male?
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gives them protein set SRY - makes gonads into testes
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What happens to gonads if they have
(1) Sry (2) No sry |
1 - testes
2 - ovaries |
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What does the Mullerian duct do?
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makes Fallop tubes, uterus, upper vag
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How do the testes make sure men don't have
Fallop tubes uterus upper vag? |
2 things - testes make:
1 - testosterone - get sem vesciles, vas def, epidid 2 - make Anti-mull hormone |
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What does the Wolf duct do?
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make sem ves, vas def, epid
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What do urogenital sinus folds make in presence of DHT?
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prostate, glands penis/shaft, scrotum
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what do urogenital sinus folds make in lack of DHT?
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clit, labia, minor/majora, lower vag
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What are 3 versions of hypogonadism?
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in utero
Eunochidism (after utero/before pub) After puberty/adult |
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what is eunochidism
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hypogonad after utero, before pub
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what is cryptochidism
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undescended testicles
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What type of hypogonadism is this?
no facial hair, anemia, Increased LH/FSH, bones normal length |
after puberty primary hypogonadism
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What type of hypogonadism is this?
no facial hair, anemia, Increased LH/FSH, no secondary sex organs |
eunochoidism
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What type of hypogonadism is this?
no facial hair, anemia, Increased LH/FSH, no male reproductive tract |
fetal primary hypogonadism
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What type of hypogonadism is this?
no facial hair, anemia, HIGHLH/FSh |
secondary hypogonadism
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Primary hypogonadism is a problem with the (1) and secondary is problem with the (2)
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1 - testes
2 - pit/hypothal |
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a - seminal vescils, vas def, epididyms
b - prostate, glands penis, shaft, scrotum c - fallopian tubes, uterus, upper vag d - lower vag, minora, majora, clit, labia |
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a - Mull Duct
b - Urogenital sinus folds c - wolf duct |
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a - Testosterone
b - DHT C - MIH |
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a - NO SRY
b - SRY |
