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131 Cards in this Set
- Front
- Back
Automonic Nervous System (ANS)
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regulates organs and organ systems, and smooth muscles and glands
also provides information to the CNS |
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Smooth muscle
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active on their own
ANS promotes/inhibits |
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ANS has 2 neurons
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Preganglionic neuron: cell body in brain or spinal cord
Postganglionic neuron: synapses and an autonomic ganglion |
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2 Divisions in ANS
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Sympathetic: fight or flight
Parasympathetic: feed or breed |
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Sympathetic
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very fine tuned responses
very short preganglionic fibers postganglionic very long |
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Divergence
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(short) preganglionic branch to synapse with number of longer postganglionic neurons
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Adrenal Medulla
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realeases epinephrine (lots) and norepinephrine (less) in blood in response to preganglionic stimulation
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Parasympathetic
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slower
alot more specific long preganglionic, short postganglionic |
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Both sympathetic and parasympathetic PREGANGLIONIC release
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ACh
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Parasympathetic POSTGANGLIONIC also release
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ACh
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Most sympathetic POSTGANGLIONIC release
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norepinephrine, but release some ACh
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Unusual Synapses
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Varicosities
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Agonists
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drugs the promote actions of a NT
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Antagonists
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drugs the inhibit actions of a NT
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Nicotinic blocked by
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Curare
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Muscarinic blocked by
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Atropine
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Dual innervation
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supplied by both sympathetic and parasympathetic
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Medulla Oblongata
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most directly controls activity of ANS
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Hypothamamus
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centers for control of body temp, hunger, and thrist
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Limbic system
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responsible for visceral responses that reflect emotional states
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Endocrine Glands
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are ductless and secrete hormones into bloodstream
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Neurohormones
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secreted into blood by specialiezed neurons
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Amine
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derived from tyrosine or trytophan
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Polypeptide and protein
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horomones are chains of amino acids
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Glycoproteins
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LH, FSH, TSH
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Steriods
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lipids derived from cholesterol
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Prohormones
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precursors of hormones
ex/proinsulin |
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Prehormones
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precursors of prohormones
ex/preproinsulin |
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hormone interaction
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2 hormones are synergistic if work together to produce an effect
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Priming effect or upregulation
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hormone induces more of its own receptors in target cells
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Desensitization or downregulation
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long exposure to high levels of polypeptide hormone
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Thyroid Hormone Action
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T4 must be converted into T3
T3 can float directly into cells and get the job done |
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cAMP
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mediates effects of many polypeptide and glycoprotein hormones
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Pituitary Gland
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Acts as an endocrine gland
Posterior and Anterior lobes controlled by hypothalamus |
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Growth hormone
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promotes growth, protein synthesis and movement of amino acids
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Thyroid stimulating hormone (TSH)
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stimulates thyroid to produce and secrete T4 and T3
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Adrenocorticotrophic hormone (ACTH)
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stimulates adrenal cortex to secrete cortisol
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Follicle stimulating hormone (FSH)
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stimulates growth of ovarian follicles and sperm production
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Luteinizing hormone (LH)
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causes ovulation and secretion of testosterone in testes
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Prolactin (PRL)
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stimulates milk production by mammary glands
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Feedback control
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short feedback loop, negative feedback, and positive feedback
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Antidiuretic hormone
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promotes H2O conservation by kidneys
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oxytocin
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stimulates contraction of uterus
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Adrenal glands
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another connection between endocrine and nervous system
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Cortisol
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inhibits glucose utilization/stimulates gluconegenesis
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aldosterone
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stimulates kidneys to reabsorb Na+ and K+
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Basil Metabolic Rate
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the way we chew up energy
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Skeletal Muscles
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attach to bon on each end by tendons
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Flexors
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decrease angle of joint
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Extensors
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increase angle of joint
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skeletal muscle structure
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highly organized
striated muscle only contract in one direction |
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Motor unit
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includes each motor neuron and all fibers it innervates
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Myofibrils
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individual protein
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Structure of myofibril
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A ban is dark contains filaments
I band is light contains thin filaments |
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Myosin wants to bind to?
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actin
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in mysoin what must get burned
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ATP
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Sliding filament theory
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muscle contracts cuz thin filaments slide over and between thick filaments
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Troponin-tropomyosin system
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control of cross bridge attachment to actin
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Tropomyosin
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interfers with myosin grabbing actin
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when calcium is taken away the process
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reverses
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Sarcoplasmic reticulum
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a calcium reservoir in muscle
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APs in T tubules cause release of Ca++ from
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cisternae
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Cardiac Muscle
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striated like skeletal but involuntary like smooth
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Smooth muscles
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has no sacromeres but has gap junctions
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Smooth muscle is very good at?
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contracting and sustaining that contraction
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cardiovascular
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heart pumps blood
blood vessels carry blood from heart to cells and back |
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Cardiovascular system includes:
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arteries, arterioles, capillaries, venules, veins
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Lymphatic system
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picks up excess fluid filtered out in capillary beds and returns it to veins
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blood consist of:
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formed elements (cells) and plasma (fluid part)
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when blood centrifuged, blood seperates:
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Formed elements on bottom and plasma on top
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adema
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decrease in proteins in blood
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3 types of plasma proteins
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albumins, globulins, and fibrinogen
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albumins
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create colloid osmotic pressure that draws H2O from interstitial fluid into capillaries to maintain blood volume and pressure
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Globulins
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carry lipids or are antibodies
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Fibrinogen
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serves as clotting factor
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Serum
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fluid left when blood clots
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formed elements
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Erythrocytes (RBCs) and leukocytes (WBCs)
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leukocytes
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has nucleus
can crawl around squeeze through capillary walls |
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Granular Leukocytes
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help detoxify foreign substances and release heparin
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Agranular leukocytes
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phagocytic and produce antibodies
Include lymphocytes and monocytes |
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Megakarocytes
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produce nuclear platelets
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Thrombocytes
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lack nucleus and are not true cells
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Hematopoiesis
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formation of clood cells from stem cells
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Erythropoiesis
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formation of RBCs
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Leukopoiesis
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formation of WBCs
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Hemostasis
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stop loss of blood and maintain blood pressure
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Vasoconstriction
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restricts blood flow to area
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Role of fibrin
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RBCs get caught
Clot forms structure for rebuilding of vessel |
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Conversion of Fibrinogen to fibrin (2 Pathways)
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Intrinsic
Extrinsic |
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Intrinsic
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Involves conversionof prothrombin to thrombin
Thrombin converts fibrinogen to fibrin |
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Extrinsic
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damaged tissue can release clotting factors that triggers a clotting shortcut
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Heart has 4 chambers
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2 atria (Left and right)
2 Ventricles (Left and Right) |
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Atria
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receive blood from venous system
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Ventricles
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pump blood to arteries
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Left Ventricle
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works 7x more than right
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Pulmonary Circulation
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path of blood from right ventricle through lungs and back to heart
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Systemic circulation
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path of blood from left ventricle to body and back to heart
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Atrioventricular
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Seperates Atrium and ventricle
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Tricuspid valve
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between right atrium and ventricle
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Bicuspid valve
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between left atrium and ventricle
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Semilunar Valves
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Pulmonary Valve
Aortic Valve |
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Systole
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refers to contraction stage
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Diastole
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refers to relaxation stages
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SA node
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functions as pacemaker
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Arteries
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expand during systole and recoil during diastole
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Arteries (cont.)
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Provide most resistance and greatest drop in pressure in circulatory system
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capillaries
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provide extensive surface area for exchange
"place where buisness of the blood gets done" |
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Veins
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bigger than arteries
very stretchy, weak, and thin low BP contain majority of blood in circulatory system |
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Lymphatic system (3 functions)
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Transports interstitial fluid back to blood
Transports absorbed fat from small intestine to blood helps provide immunological defenses against pathogens |
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Lymph is carried from lymph capillaries to:
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Lymph ducts to lymph odes
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Cardiac Output (CO)
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is volume of blood pumped/min by each ventricle
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Stroke Volume (SV)
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volume of blood pumped/beat by each ventricle (mL/beat)
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Heart Rate (HR)
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the number of beats/minute
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Cardiac Rate is controlled by
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autonomic
sympathetic increase cardiac performance Parasympathetic decrease cardiac performance |
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SA node is:
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main controller for HR
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Parasympathetic releases:
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ACh
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Norepinephrine and epinephrine
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increase or stimulate HR
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ACh:
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Decrease HR
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Stroke Volume (3 variables)
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End diastolic volume (EDV)
Total Peripheral Resistance (TPR) Contractility |
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End Diastolic Volume (EDV)
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amount of blood in a ventricle when it is relaxed
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Total Peripheral Resistance (TPR)
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amount of work the heart has to work against
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Regulation of Stroke volume
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EDV is preload
TPR is afterload |
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Ejection Fraction
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SV/EDV
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Venous Return
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resvoir that resides in our veins
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Hydrostatic
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amount of squeezage
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Vasodilation
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decreases resistance, increases blood flow
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Vasoconstriction
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decrease blood flow
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Blood Pressure
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Increase or Decrease in sympathetic
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Blood Pressure (cont.)
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mainly controlled by HR, SV, and peripheral resistance
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Pulse pressure
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(systolic pressure) - (diastolic pressure)
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Mean Arterial pressure (MAP)
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represents average arterial pressure during cardiac cycle
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