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10 Cards in this Set
- Front
- Back
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The ________ _______ is the store of Ca++ in the muscle cells
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Sarcoplasmic Reticulum
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______________ form junctions with the sarcoplasmic reticulum
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T-tubules
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What are the two coupled receptors connecting the T-tubules to the SR?
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DHP receptors and Ryanodine receptors (RyRs)
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Ca++ enters the skeletal muscle cytosol and triggers the RyRs to open (True/False)
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False (the DHPRs and RyRs are mechanically coupled in skeletal muscle and the entrance of extracellular Ca++ is not required)
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In _________ muscle, DHPR/RyR arrangement is less organized
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cardiac
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What is the primary means of removing Ca++ from the muscle cell cytosol?
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SERCA pump pumps it back into the cytosol
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What happens in malignant hyperthermia?
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Mutation in the I site of RyR causes it to have a lower affinity, thereby releasing more Ca++ into the cytosol, lots of energy is spent pumping Ca++ out of the cytosol and heat is produced
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What determines contractile force?
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the number of cross-bridges formed
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What would be the effect of decreasing the size of the SR Ca++ store?
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decrease the force of contraction
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What would be the effect of increasing SERCA pump activity?
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increase the rate of relaxation
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