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17 Cards in this Set

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Hemoglobin breaks down into?
Globin (reused)
Heme (oxidized to Hemin (Fe+3))
Hemin--->Porphyrin ring--->Bilirubin
-
Hemin--->Biliverdin
Heme oxygenase
Biliverdin ---> Bilirubin
Biliverdin reductase
-Bilirubin is unconjugated so not water soluble
1. UDP glucose ---> UDP glucuronic acid
UDP glucuronyl dehydrogenase
2. UDP glucuronic acid + Bilirubin ---> Bilirubin diglucuronide + UDP
UDP glucuronyl Transferase
Bilirubin now conjugated: water soluble
3. Bilirubin diglucuronide --->Glucuronic acid + Bilirubin
Bacteria
Bilirubin ---> Mesobilirubinogen--->Stercobilinogen --->Stercobilin
-
What is colorless and excreted in urine?
Stercobilinogen
What is brown and found in feces?
Stercobilin
Bilirubin ---> Mesobilirubinogen--->Stercobilinogen --->Stercobilin
-
What is colorless and excreted in urine?
Stercobilinogen
What is brown and found in feces?
Stercobilin
Pre-hepataic jaundice
xs RBC breakdown
high conj.
very high nonconj.
Intra-hepatic
defective conj. E
low conj.
high nonconj.
Post-hepatic
Bile duct obstruction
high conj.
high to normal nonconj.
Neonatal Physiological Jaundice (non-conjugated hyperbilirubinemia)
Hepatic sys. not developed enough to process bilirubin
Defect in UDP glucuronyl transferase or UDP glucuronic acid
Treatment w/ Phenobarbital (induce gene expression for E) or Phototherapy