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17 Cards in this Set
- Front
- Back
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Hemoglobin breaks down into?
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Globin (reused)
Heme (oxidized to Hemin (Fe+3)) |
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Hemin--->Porphyrin ring--->Bilirubin
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-
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Hemin--->Biliverdin
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Heme oxygenase
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Biliverdin ---> Bilirubin
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Biliverdin reductase
-Bilirubin is unconjugated so not water soluble |
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1. UDP glucose ---> UDP glucuronic acid
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UDP glucuronyl dehydrogenase
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2. UDP glucuronic acid + Bilirubin ---> Bilirubin diglucuronide + UDP
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UDP glucuronyl Transferase
Bilirubin now conjugated: water soluble |
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3. Bilirubin diglucuronide --->Glucuronic acid + Bilirubin
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Bacteria
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Bilirubin ---> Mesobilirubinogen--->Stercobilinogen --->Stercobilin
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-
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What is colorless and excreted in urine?
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Stercobilinogen
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What is brown and found in feces?
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Stercobilin
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Bilirubin ---> Mesobilirubinogen--->Stercobilinogen --->Stercobilin
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-
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What is colorless and excreted in urine?
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Stercobilinogen
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What is brown and found in feces?
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Stercobilin
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Pre-hepataic jaundice
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xs RBC breakdown
high conj. very high nonconj. |
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Intra-hepatic
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defective conj. E
low conj. high nonconj. |
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Post-hepatic
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Bile duct obstruction
high conj. high to normal nonconj. |
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Neonatal Physiological Jaundice (non-conjugated hyperbilirubinemia)
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Hepatic sys. not developed enough to process bilirubin
Defect in UDP glucuronyl transferase or UDP glucuronic acid Treatment w/ Phenobarbital (induce gene expression for E) or Phototherapy |
