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42 Cards in this Set
- Front
- Back
Categories of Neurotransmitters
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* I. Acetylcholines
* II. Monoamines * III. Amino Acids * IV. Peptides * V. Other |
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II. Monoamines
(Every Monoamines contains one N2H(2 Nitrogen's & a Hydrogen molecule) group. Monoamines are looked at most when treating psych disorders. |
* A. Catecholines
* B. Indolemines * C. Histamines |
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A. Catecholines
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* 1. DA
* 2. NE * 3. E |
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B. Indolemines
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* 1. Melatonin
* 2. Serotonin |
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III. Amino Acids (Every Amino Acids contains an Amine & Carboxyl group (COOH))
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* A. GABA
* B. Glycine * C. Glutamate * D. Aspartate |
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IV. Peptides (A chain of Amino Acids. Peptides are the only NT group we are learning about that also functions and Hormones.)
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* A. Substance P
* B. Endorphin * C. Neuropeptide S * D. Neuropeptide Y * E. Vasopressin * F. Oxytocin |
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V. Other
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* A. Lipids
* B. Nucleotides * C. Gases |
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Acetylcholine (ACh)
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The molecules Acetate & Choline together
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Where do you get Acetylcholine?
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* You get the Acetate from acids in your diet.
* You get the Choline from Soy, Peanuts, Cauliflower… |
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What is ACh broken down by?
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Acetylcholine Esterase
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Action is PNS by ACh
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Activates every muscle in the body.
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Action in the CNS by ACh
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• Learning & Memory, primarily in Hippocampus.
• Sleep & Arousal, particularly in Reticular Activating System (RAS). • REM sleep, in the Pons. • Active in Parasympathetic NS. • Depending on person, Has to do with depression. That’s what Tricyclic Anti-Deps were trying to treat. Tricyclic Anti-Deps lower Acetylcholine levels. Side effects are memory issues and messes with sleep patterns. |
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Catecholines
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* Chemically changed by:_MAO (Monoamine Oxidase – the enzyme which breaks down the Catecholines)_.
* Catecholines are very similar to each other. |
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Dopamine (DA) Plays a role in:
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* Sympathetic arousal:
* Wakefulness: * Hormones: * Pleasure and affect: * Sex: * Food: * Any drug or other addiction: * Sleep: * Mental Disorders: |
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Increase in DA in Limbic system(emotion center) is seen in:
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Schizophrenia (increase of hallucinations, flat affect(socially withdrawn)). The drug Thorazin alleviates some of these symptoms.
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Decrease of DA seen in:
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Parkinson’s.
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Dysfunction of DA level in:
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Eating Disorders.
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Dysfunction of DA:
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Affects attention in learning and memory.
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D4 receptor has to do with:
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Thrill seeking.
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Norepinephrine (NE) plays a role in:
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* Arousal
* Active emotions * Disorders * Learning and Memory * Eating |
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Epinephrine (E) plays a role in:
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Sympathetic NS
Generalized anxiety Learning and memory Shyness and introversion |
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Indolamines:
- What is the precursor of Melatonin & Seratonin? |
* Triptophan
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What NT is key for sleep?
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Melatonin
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What NT is linked with Depression more than any other NT?
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Seratonin
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90% of what NT is found in the Intestines?
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Seratonin.
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Antipsychotic drugs do what?
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Block Serotonin Receptors
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Anti-Anxiety drugs do what to Serotonin?
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Increase Serotonin levels
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Hallucinogen Drugs do what to Serotonin?
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Mess up Serotonin levels.
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Serotonin plays a role in?
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depression
OCD Impulsive disorders Affect (Emotion) Eating and drinking Arousal (Both Alertedness and Sleepiness) |
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Histamines have to do mostly with ____.
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Allergies.
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Mast Cells:
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Cells that release Histamine.
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What does Histamine do to body?
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* Dilates Capillaries
* Causes flaring of wounds. |
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What does Histamine play a role in?
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• Arousal
• Eating or drinking • Pain |
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Amino Acids and their roles
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The roles they play
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GABA Plays a role in:
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• Arousal
• Epilepsy • Estrogen levels |
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Glycine: (Mostly _Inhibitory_) Plays a role in...
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• Anorexia
• Sleep |
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Glutamate- major _Excitatory_ NT in your brain, Plays role in:
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• Especially important in Learning and Memory.
• Visual Development • Conductor of _Mild_ pain • Arousal • Disorders • Addiction |
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What is Glutamates particular receptor?
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NMDA
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Why is Glutamate crucial in learning?
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It increases New Synapses.
With NMDA, if there’s an increase in Glutamate, then there’s an increase in Calcium which increases Dendrite Bunches and New Synapses. |
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Too much Glutamate kills _____ and can lead to ________.
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* neurons
* Amnesia |
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Aspartate is chemically similar to _____.
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Glutamate.
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Highest amount of Aspartate found in the _______.
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_Thalamus_(The Switchboard)
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