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271 Cards in this Set

  • Front
  • Back
which of the following is the cell membrane MOST permeable to?
A. sodium
B. calcium
C. potassium
D. chloride
E. water
E. water
the most appropriate term for referring to one X+ and one Y- leaving the cell in an ATP-dependant process is?
A. facilitated diffusion
B. non-electrogenic activity symport
C. hyperpolaricing active symport
D. depolarizing active antiport
E. passive diffiusion
B. non-electrogenic active symport
which of the following would tend to decrease the rate of movement of X between two compartments separated by a membrane?
A. decreased hydration sphere for X
B. heating the solutions ing ehcompartments
C. decrease the thinkness of the membrane
D. increase the surface area ofht e membrane
E. increase the vander waals forces int ehmembrane(viscosity)
E. increase the vander waals forces int ehmembrane(viscosity)
you add a protein to the extracellular fluid bathing a cell and later find the protein in the intracellular fluid. the most likely way the protein got into the cell was by?
A. exocytosis
B. phagocytosis
C. pinocytosis
D. high-affinity reuptake
E. passive diffusion
B. phagocytosis
the nernst equation is derived from?
A. the goldman equation
B. fick's law
C. the second law of thermodynamics
D. the gibbs-donnan equilibrium
E. ohm's law
C. the second law of thermodynamics
the ion most involved in determining resting membrane potential is?
A. potassium
B. sodium
C. calcium
D. phosphate
E. bicarbonate
A. potassium
in comparison to adults, calcium turnover in children's bons...
A. is greater
B. is less
C. occurs priarily in the ends of long bones
D. occurs primarly in cortical bone
E. does not involve phosphate
A. is greater
increased activity during childhood would tend to...
A. increase bone length
B. increase bone thickness
C. increase bone calcium
D. all of the above
E. A and B but not C
E. A and B but not C
the majority of daily dietary calcium..
A. is incorporated into bone
B. is lost in the feces
C. is lost in the urine
D. is trapped in the rapidly exchangable pool
E. remains in extracellular fluid
B. is lost in the feces
osteoblasts decrease the chance of exceeding solubility product inside the cell by...
A. forming phosphate esters
B. pumping calcium into the osteoid
C. activating alkaline phosphatase
D. all the above
E. A and B, but not C
E. A and B, but not C
a protein found in both osteoblasts and osteoclasts is
A. alkaline phosphatase
B. acid phosphatase
C. carbonic anhydrase
D. collagenase
E. all the above
C. carbonic anhydrase
maximum bone mass is reached at about age?
A. 3
B. 17
C. 25
D. 50
E. 70
C. 25
which of the following is FALSE?
A. the H zone decreases during contraction
B. the I band decreases during contraction
C. the A band decreases during contraction
D. this filament length remains constant during contraction
E. thick filament length stays constant during contraction
C. the A band decreases during contraction.
which of the following would not be found in the thin filaments?
A. F-actin
B. tropomyosin
C. troponin C
D. light chain myosin
E. ADP
D. light chain myosin
in the sliding filament theory, ATP is used to?
A. break existing crossbridges
B. "Cock" the mysoin heads
C. act as a binding site on the thin filaments
D. all of the above
E. A and B, but not C
A and B , not C
a motor unit is?
A. a single muscle cell and the neurons which innervate it
B. a single neuron and the muscle cells that it innervates
C. the area of the skeletal muscle cell membrane at the synapse
D. the group of muscle cells contracting during a muscle twitch
E. the cortical neurons responsible for coordinatind a movement.
B. a single neuron and the muscle cells that it innervates
which of the following is most likely to result if calseqwestrin is destroyed in a muscle cell?
A. increased muscle tone
B. decreased contractile strength
C. increased frequency of muscle action potentials
D. destruction of t-tubules
E. flaccid paralysis
A. increased muscle tone
twitch tension exists after active contraction because of the presence of?
A. ATP
B. the series elastic element
C. action potential reverberation
D. slow resequestration of calcium by the sarcoplasmic reticulm
E. muscle being maintained
D. slow resequestration of calcium by the sarcoplasmic reticulum
which type of muscle is characterized by large fiber size, no pacemaker potentials and fatigues easily?
A. fast twitch skeletal
B. slow twitch skeletal
C. single unit smooth
D. multi-unit smooth
E. cardiac
A. fast twitch skeletal
smooth muscle contraction is regulated by?
A. calcium binding to troponin
B. release of calcium from the sarcoplasmic reticulum
C. phosphorylation of myosin by myosin light chain kiase
D. calmodulin actication of myosin phosphatase
E. all the above
C. phosphorylation of myosin by myosin light chain kinase
which of the following is NOT seen to stimulate smooth muscle contraction?
A. acetylcholine
B. norepinephrine
C. strech
D. depolarization of slow wave potentials
E. all of the above will stimulate smooth muscle contraction
E. all the above will stimulate smooth muscle contraction.
which muscle type is maintained below the peak of the length-tension curve?
A. fast teitch skeletal
B. multi-unit smooth
C. cardiac.
D. single-unit smooth
E. all of the above
C. cardiac
which of the following is realesed in response to fat in the duodenum and stimulate the bladder contraction?
A. gastrin
B. cholecystokinin
C. secretin
D. enterokinase
E. GIP
B. cholesystokinin
which of the following is correct?
A. multi unit smooth muscle is important in perstaltic contractions
B. the stomach exhibits the lowest frequency of slow waves in the GI tract
C. norepinephrine causes slow wave hyperpolarization in the GI tract
D. sphincters consume much ATP in mantaining the eir contracted state
E. the enteric nervous system contains only motor neurons
C. norepinephrine causes slow wave hyperpolarization in the GI tract
which of the following is NOT an appropriate trigger for peristalsis?
A. local distension
B. vagal innervation
C. local irritation
D. activation of the myinteric reflex
E. all of the above
E. all of the above
which reflex accounts for slowed stomach emptying as chyme enters the duodenum?
A. enterogastric
B. gastrocolic reflex
C. coloileal reflex
D. myenterc reflex
E. gastroileal reflex
A. enterogasteric reflex
bicarbonate for neutralizing chyme acidity is primarily produced by?
A. duodenal enterocytes
B. tubular epithelium of the pancreas
C. hepatocytes
D. pancreatic acinar cells
E. oxyntic glands
B. tubular epithelium of the pancreas
which of the following is FALSE regarding carbohydrate digestion?
A. digestive products are absorbed as disaccharides
B. water accompanies absorption of sugars
C. sodium accompanies absorption
D. digeestion occures ing ehmouth, stomach and small intestine
E. all the above
A. digestive products are absorbed as disacharides
lipids which are absorded are initially transported in blood as?
A. micelles
B. chylomicrons
C. VLDLs
D. LDLs
E. HDLs
B. chylomicrons
the reason that our cells have a membrane potential is?
A. the sodium/potassium pump creates it.
B. proteins are primarily present in intracellular low
C. calcium permeability
D. the absence of electrogenic pumps in the cell membrane
E. the osmotic imbalance between intra and extracellular fluids
B. proteins are primarily present in intracellular fluid
which of the following has the LOWEST intracellular concentration?
A. potassium
B. sodium
C. calcium
D. chloride
E. phosphate
C. calcium (.ooo1)
the process of taking up extracellular fluid into titracellular vesicles is called?
A. exocytosis
B. pinocytosis
C. phagocytosis
D. symport
E. antiport
B. pinocytosis
an impermeable ion entering a cell along its electrochemical gradient will primarily do so by?
A. passive diffusion
B. exocytosis
C. active transport
D. facilitated diffusion
E. osmosis
D. faciliated diffusion
sodium/potassium ATPase is an expamle of
A. an ATP-dependent pump
B. an electrogenic pump
C. antiport
D. all the above
E. A and B but not C
D. all the above
the rate of diffusion across a membrane will be increased by all of the following EXCEPT?
A. increased concentration gradient
B. increased membrane conductance
C. increased temperature
D. decreased membrane fluidity
E. decreased membrane thickness
B. increased membrane conductance
the NET diffusional force on an ion is?
A. the concentration gradient for the ion
B. the valence of the ion and the membrane potential
C. the Gibbs free energy on ion diffusion
D. all the above
E. A and B but not C
C. the Gibbs free energy of diondiffusion
at rest, the cell membrane is most permeable to?
A. bicarbonate
B. chloride
C. calcium
D. sodium
E. potassium
E. potassium
in order to calculate driving force on an ion, you need all of the following EXCEPT:
A. permeability for the ion
B. intracellular concentration
C. extracellular concentration
D. temperature
E. membrane potential
D. temperature
the goldman equation is used to?
A. estimate mebrane relative permeabilities for ions
B. estimate membrane potential
C. determine intracellular ion concentrations
D. determine the average driving force on all ions
E. determine the amount of evergy released by average ion diffusion
B. estimate membrane potential
a specific inhibitor of the sodium/potassium pump is?
A. ouabain
B. tetrodotoxin
C. tetuaethy lammonium
D. curare
E. botulinum toxin
A. ouabain
bone receives about 5% of cardiac output (200-400 ml/min), which is less extensive than for cartilage.
A. the first clause is correct, and the second clause is correct
B. the first clause is correct, but the second clause is incorrect
C. the first clause is incorrect, and the second clause is incorrect
D. the first clause is incorrect, but the second clause is correct
E. the actual information listed in the sentence is still undermined
A. the first clause is correct, and the second clause is correct
which of the following cells does NOT depend on bone marrow for production of that cell type?
A. osteoblasts
B. osteoclasts
C. erythrocytes
D. lymphocytes
E. platelets
A. osteoblasts
peak body bone mass occurs around age?
A. 13
B. 18
C. 25
D. 40
E. 50
C. 25
the Gemini study linked _____to demineralization of bone
A. flight
B. increased age
C. low gravity
D. low activity
E. osteocyte antagonists
D. low acticity
bone "remodeling"
A. occurs throught our life
B. is the balance between bone synthesis and resorption
C.is greatest is cancellous bone
D. is greater in children than in adults
E. all the above
E. all the above
a plasma calcium concentration of 4 mM
A. is referred to as hypocalcemia
B. would tend to promote bone resorption
C. is most likely to be seen just before eating a meal
D. would likley result in calcium phosphate precipitation
E. is used in the treatment of stoke
D. would likley result in calcium phosphate precipitation
most dietary calcium ends up in
A. the feces
B. the urine
C. extracellular fluid
D. muscle
E. bone
A. the feces
most of the phosphate in our body is found in
A. mitochondria
B. sarcoplasmic reticulum
C. bone
D. extracellular fluid
E. ATP
C. bone
collagen is present in bone to provide
A. compressive strength
B. tensile strength
C. elastic strength
D. a permanent matrix for calcification
E. cytoskeletal structure for osteoblasts
B. tensile strength
which of the following hormones promotes bone growth by inhibiting resorption?
A. growth hormone
B. thyroid hormon
C. cortisol
D. estrogen
E. insulin
D. estrogen
which of the following is implicated as a local signal in producing bone loss with periodontal disease?
A. prostaglandin E
B. interleukin 1
C. tumor necrosis factor a
D. integrin
E. fibroblast growth factor 2
A. prostaglandin
the covalent crosslinks between collagen fibrils are formed by the enzyme
A. prolyl hydroxylase
B. lysyl oxidase
C. collagenase
D. carbonic anhydrase
E. thrombin
B. lysyl oxidase
which of the following agents would NOT cause spastic paralysis?
A. carbachol
B. curare
C. physostigmine
D. nerve gas
E. methacholine
B. curare
increasing the load prior to an isotonic twitch
A. decreases delay, decreases distance moved, and increases velocity of shortening
B. increases delay, decreases didtance moved, and increases velocity of shortening
C. decreases delay, increases distance moved, and decreases velocity of shortening
D. increase delay, decrease distance moved, and decrease velocity of shortening
E. increase delay, increases distance moved, and decreases velocity of shortening
D. increases delay, decreases distance moved, and decreases velocity of shortening
which of the following would you NOT expect to be characteristic of muscle fibers in antigracity muscles?
A. many mitochondria
B. myoglobin
C. high glycogen
D. slow myosin ATPase
E. all of the above
C. high glycogen
muscle fatigue and rigor mortis share what characteristic?
A. lack of stimulation
B. low ATP levels
C. low intracellular free calcium
D. inhibition of crossbridge formation
E. all of the above
B. low ATP levels
summation of muscle twitch tension is possible even though muscle action potentials cannot summate because
A. calcium remains elevated longer than the duration of the muscle action potential
which is NOT a diference between skeletal and smooth muscle?
A. breadth of length-tension relationship
B. maximal tension that can be developed
C. presence of troponin
D. inhibition of contraction by norepinephrine
E. presence of slow waves
B. maximal tension that can be developed
activation of myosin light-chain kinase
A. participates in skeletal muscle regulation of contraction
B. results in inhibition of myosin ATPase
C. would tend to increase the strength of contraction of smooth muscle
D. is inhibited by calcium unbinding from calmodulin
E. occurs when troponin binds to calcium
D. is inhibited by calcium unbinding from calmodulin
which of the following is NOT a component of the thin filaments?
A. G-actin
B. tropomyosin
C. troponin C
D. ADP
E. all the above
E. all the above
which of the following occurs immediately following the "power stroke"?
A. ATP binds to myosin
B. ADP binds to myosin
C. ADP unbinds from actin
D. ATP is hydrolyzed by myosin
E. ATP is hydrolyzed by actin
D. ATP is hydrolyzed by myosin
transmission at the neuromuscular junction is primarily terminated by
A. washout
B. high-affinity reuptake of acetylcholine
C. high-affinity reuptake of choline
D. catabolism by acetylcholine esterase
E. catabolism by choline acetyl transferase
D. catabolism by acetylcholine esterase
crossbridging occurs within the
A. z disc
B. I band
C. H zone
D. A band
E. M line
D. A band
in skeletal muscle calcium binds to
A. tropomyosin
B. myosin phosphorylase
C. calmodulin
D. troponin C
E. troponin I
D. troponin C
the combination of a neuron and the muscle cells it innervates is:
motor unit
a calcium-binding protein fornd in the sarcoplasmic reticulum is:
calsequesterin
1. During the period of after hyperpolarization following an action potential
Sodium permeability is lower than at rest
Calcium permeability is elevated
Potassium permeability is higher than at rest
Chloride permeability is reduced
All of the above
Potassium permeability is higher than at rest
2. Which of the following is an effector?
Nicotinic cholinergic receptor
Inositol triphosphate
Acetylcholine
Adenylate cyclase
Calcium
Acetylcholine
3. Which of the following increases membrane fluidity?
Longer fatty acid chains in phosphatidylcholine
Fewer unsaturated fatty acids in spingomyelin
Lower cholesterol content of the membrane
All of the above.
A and B, but not C
Lower cholesterol content of the membrane
4. This bond type is more important than any other in holding components of a leaflet together:
Covalent
Electrostatic
Hydrogen
Van der Waals
B and C
Van der Waals
5. The most abundant component in cells is/are:
Water
Sugars
Inorganic ions
Fats
Proteins
Water
6. Presynaptic receptors:
Partially depolarize the nerve terminal
Are usually used to decrease exocytosis of neurotransmitter
Decrease the amount of calcium that enters a nerve terminal
Usually decrease the responses of target cells to subsequent action potentials
All of the above
Are usually used to decrease exocytosis of neurotransmitter
8. Which statement is INCORRECT?
Water is the universal solvent of life
Water is both an H bond donor and acceptor
Water is uncharged
Water stabilizes ions by forming electrostatic bonds
All of the above are correct.
All of the above are correct.
9. Calmodulin participates in
Protein anchoring
Regulatory protein control
Enzyme phosphorylation
Proteolytic activation
Feedback inhibition
Regulatory protein control
10. Water
causes hydrophobic compounds to "clump" together
acts as though it has both positive and negative charge
is the most concentrated compound in life
is a great source for hydrogen bonds
All of the above
All of the above
11. Cellular membranes
have a high concentration of proteins in mitochondrial membranes
have a protein component which produces a barrier to diffusion
can be classified as micelles
have a lipid component which does the active work of the membrane
All of the above
have a high concentration of proteins in mitochondrial membranes
12. Which of the following would tend to increase membrane fluidity?
Decreased temperature
Increased Van der Waals bonding
Increased percentage of unsaturated fatty acids
Increased cholesterol content
All of the above
Increased percentage of unsaturated fatty acids
13. Which of the following represents the most diverse group of compounds in cells?
Proteins
Lipids
Sugars
Ions
Water
Proteins
14. An extracellular receptor signaling system
produces a second messenger
requires a protein on the extracellular leaflet of the cell membrane
may or may not require a G-protein
requires an effector
All of the above
All of the above
15. The most rapid form of cell-to-cell communication is accomplished using
gap junctions
hormones
neurotransmitters
autocrines
paracrines
gap junctions?
16. Calcium can exert effects in cells by
combining with calcium-binding proteins, which can then activate specific enzymes
directly phosphorylating proteins
inhibiting calmodulin
inhibiting protein kinase C
All of the above
combining with calcium-binding proteins, which can then activate specific enzymes
17. Cyclic AMP
usually inhibits the activity of synthetic enzymes
inhibits phosphoprotein phosphatase
stimulates certain protein kinases
causes protein phosphorylation
All of the above
causes protein phosphorylation
22. Which of the following is dependent on cellular energy?
Ionophore-mediated ionic movement
Active transport
Passive diffusion
Facilitated diffusion
More than one of the above
Active transport
23. The Nernst potential:
is the membrane potential needed to counteract the concentration gradient of an ion
is the summed electrical force contributing to the membrane potential by sodium, potassium and chloride
is negative at rest
for an ion changes during the course of an action potential
is the concentration gradient of an ion at resting membrane potential
is the membrane potential needed to counteract the concentration gradient of an ion
24. At rest:
PNa = PK = PCl
PK > PCl > PNa
PCl > PK > PNa
PNa > PCl > PK
PNa > PK > PCl
PK > PCl > PNa
25. Which statement is INCORRECT regarding the depolarization phase of the action potential?
Sodium permeability is greater than potassium permeability
Both gates in the voltage-gated sodium channels are open
Potassium permeability is greater than at rest
Voltage-gated potassium channels are opening
All of the above are CORRECT
All of the above are CORRECT
26. During the period of the afterhyperpolarization
the membrane potential is more negative than the resting membrane potential
potassium permeability is lower than normal
the sodium channel inactivation gates are closed
a new action potential cannot be generated
All of the above are correct
the membrane potential is more negative than the resting membrane potential
27. Which of the following is true regarding facilitated diffusion?
1. It involves specific protein carrier molecules
2. It requires direct use of cellular energy (such as ATP)
3. It is involved with the movement of molecules down their electrochemical gradient
4. It only involves the movement of water across the membrane
1 and 3
2 and 3
2 and 4
1, 2 and 3
1, 2, 3 and 4
1 and 3
28. The membrane potential most closely resembles the Nernst potential of
1. the least permeable ion
2. the most permeable ion
3. potassium, when the neuron is at rest
4. sodium when the neuron is at rest
1 and 3
2 and 3
2 and 4
1, 2 and 3
1, 2, 3 and 4
2 and 3
29. The membrane potential most closely resembles the Nernst potential of
1. potassium, when the neuron is at rest
2. sodium, at the peak of the action potential
3. the most permeable ion
4. the least permeable ion
1 and 3
2 and 3
2 and 4
1, 2 and 3
1, 2, 3 and 4
1,2, and 3
30. When is the sodium activation gate closed and the inactivation gate open?
1. At rest
2. During the absolute refractory period
3. During the relative refractory period
4. During the depolarization phase of the action potential
1 and 3
2 and 3
2 and 4
1, 2 and 3
1, 2, 3 and 4
1 and 3
Which statement about saliva is INCORRECT?

* Parotid glands produce serous saliva containing amylase
* The presence of mucin in saliva increases fricition between teeth
* Lactoferin binds to iron and acts as an antibacterial agent
* Proline-rich proteins bind phosphate and prevent precipitation of calcium phosphate
* Viscous saliva is secreted by submandibular and sublingual glands
The presence of mucin in saliva increases fricition between teeth
Which of the following tissues has the greatest capacity for gluconeogenesis?

* Liver
* Brain
* Heart
* Adipose
* Pancreas
* Liver
Which organ produces Secretin?

* Saliva
* Stomach
* Duodenum
* Pancreas
* Liver
* Duodenum
Segmentation contractions of the small intestine provide which primary function?

* Propulsion of contents through the gastrointestinal tract
* Mixing of ingested material with gastrointestinal secretions
* Bulk flow of gastrointestinal contents into the interstitium
* Absorption of fats into the lymphatic system
* Emptying of the gall bladder
* Mixing of ingested material with gastrointestinal secretions
Dietary triglycerides are transported to the liver in the form of

* Micelles
* Chylomicrons
* Very low density lipoproteins
* Low density lipoproteins
* High density lipoproteins
* Chylomicrons
Which component of saliva acts to buffer oral pH at neutrality?

* Statherin
* Mucin
* Bicarbonate
* Histatius
* Water
* Bicarbonate
The majority of bile salts released by the gall bladder are

* Excreted in the feces
* Metabolized by bacteria in the colon
* Reabsorbed and transported in the portal circulation for reuse
* Reabsorbed and transported in the lymphatics
* Reabsorbed, metabolized in the liver and excreted in the kidneys
* Reabsorbed and transported in the portal circulation for reuse
The most important gastric function of hydrogen ion secretion in the stomach is the

* Neutralization of ingested saliva
* Direct hydrolyzation of ingested protein
* Conversion of Pepsinogen to Pepsin
* Stimulation of Enterokinase
* Stimulation of Gastrin release
* Conversion of Pepsinogen to Pepsin
Which of the following will tend to increase calcium absorption in the small intestine?

* Increased secretion of Intrinsic Factor
* Increased secretion of 1,25 dihydroxycholecalciferol
* Decreased secretion of Parathyroid Hormone
* A high fat diet
* A high protein diet
* Increased secretion of 1,25 dihydroxycholecalciferol
Which of the following would be expected to be occurring at three hours of a fast?

* Increased fat synthesis
* Decreased glycogen in the liver
* Elevated plasma glucose
* Inhibition of gluconeogenesis
* Increased brain consumption of ketones
* Decreased glycogen in the liver
Gallbladder emptying is stimulated by

* Neural reflex via the splanchnic nerve
* Neural reflex via the enteric nervous system
* Enterocrinin
* Cholecystokinin
* Enterokinase
* Cholecystokinin
Taurocholate and glycocholate are involved in the absorption of

* Sugars
* Amino acids
* Fatty acids
* Nucleic acids
* Glycerol
* Fatty acids
Which of the following observations supports the hypothesis that saliva production is an active process?

* Vasodilation occurs in salivary glands during saliva secretion
* Blood flow through salivary glands is increased during salivation
* Blood flow is decreased to salivary glands during salivation
* Salivation stops when pressure in the salivary duct is equal to arterial blood pressure
* Salivation continues when salivary duct pressure is greater than arterial blood pressure
* Salivation continues when salivary duct pressure is greater than arterial blood pressure
Which of the following is a result of the enterogastric reflex?

* Increased gastric secretion
* Increased gastric motility
* Increased intestinal motility
* Decreased gastric motility
* Decreased intestinal motility
* Decreased gastric motility
Which of the following plays a major role in decreasing shear forces in the mouth?

* Mucin
* Exasin
* Lectin
* Lactoferin
* Histasius
* Mucin
Which of the following proteins is involved in calcium phosphate regulation in saliva?

* Histasius
* Adhesin
* Lectin
* Statherin
* Mucin
* Statherin
An important reason for regulating calcium and phosphate in the mouth is because

* high levels cause the pH of the mouth to become acidic
* precipitation of calcium phosphate causes calculus
* bacteria require calcium and phosphate for growth
* if calcium levels are too high, tooth enamel becomes too thick
* All of the above
* precipitation of calcium phosphate causes calculus
Many of the different types of proteins found in saliva assist in

* lubrication
* antibacterial and antifungal functions
* transporting trace elements into the gut
* neutralizing pH
* digesting starch
* antibacterial and antifungal functions
Which of the following statements about saliva and salivary glands is correct?

* Epinephrine inhibits amylase secretion by parotid glands by decreasing cAMP
* Dry food will inhibit salivation
* Potassium iodide and mercury are excreted, in part, by incorporation into saliva
* Salivary mucopolysaccharides are important as salivary buffers
* Saliva increases shearing forces between teeth
* Potassium iodide and mercury are excreted, in part, by incorporation into saliva
Which of the following is NOT secreted by the pancreas?

* Lipase
* Trypsinogen
* Chymotrypsinogen
* Enterokinase
* Procarboxypeptidase
* Enterokinase
Which of the following is secreted in its active form?

* Trypsin
* Chymotrypsin
* Carboxypeptidase
* Amylase
* Pepsin
* Amylase
What is the fate of most bile salts following their function in the small intestine?

* Excretion in the unmetabolized form in the feces
* Excretion in the urine
* Reabsorption and transport in the lymphatics
* Reabsorption and transport in the portal circulation
* Destruction by bacteria in the large intestine
* Reabsorption and transport in the portal circulation
Which of the following enzymes breaks triacylglycerol into 4 fragments?

* Lipase
* Glycerol kinase
* Acyl CoA dehydrogenase
* Acyl CoA synthase
* ?-ketothiolase
* Lipase
Which of the following contains ?-amylase in its secretion?

* Facial glands
* Parotid glands
* Sublingual glands
* Submaxillary glands
* Gastric glands
* Parotid glands
Which of the following is a salivary component which helps to neutralize acids in the mouth?

* Mucin
* Ammonia
* Bicarbonate
* Histidine
* Statherin
* Bicarbonate
Which of the following situations would generate ketosis?

* Fasting
* Low fat diet
* Low sodium diet
* High carbohydrate diet
* High water consumption
* Fasting
Which of the following is INCORRECT regarding viscous saliva?

* Viscous saliva contains mucin
* Viscous saliva is produced by submandibular glands
* Viscous saliva is produced by sublingual glands
* Viscous saliva contains amylase
* All of the above are correct
* Viscous saliva contains amylase
Alkaline salivary pH is important because

* it makes saliva "slippery", decreasing friction between teeth
* it accentuates calcium phosphate deposition on teeth
* it decreases calculus formation
* acidic pH makes our mouth feel soapy
* evasins are neutralized at high pH
* it decreases calculus formation
Which of the following is a salivary protein which provides saliva with an antifungal function?

* Mucin
* Immunoglobulin
* Histatius
* Lysozymes
* Lactoferin
* Histatius
Calcium and phosphate regulation in saliva

* is important for maintaining calcium in a saturated state
* promotes catabolism of starch by amylase
* accelerates decalcification of enamel
* is carried out in part by statherin, which binds calcium
* All of the above are correct
* is important for maintaining calcium in a saturated state
Which of the following is the most potent inhibitor of gastric emptying?

* Water
* Fats
* Carbohydrates
* Proteins
* Vitamins
* Fats
Trypsinogen is activated by

* the acidity of the stomach
* pepsin
* enterokinase
* chymotrypsin
* cholecystokinin
* enterokinase
Which of the following is NOT produced by the pancreas?

* Elastase
* Lipase
* Amylase
* Pepsinogen
* Trypsinogen
* Pepsinogen
The primary cause of duodenal ulcers is

* excess gastric acid secretion
* decreased pancreatic bicarbonate secretion
* excess pancreatic acid secretion
* decreased gastric bicarbonate secretion
* helicobacter pylori
* helicobacter pylori
The most common cause of gastroesophageal reflux disease (GERD) is

* gastric dysmotility
* lower esophageal sphincter incompetence
* excess histamine secretion
* obesity
* stenosis of the pyloric sphincter
* lower esophageal sphincter incompetence
Dietary fatty acids initially enter the circulatory system as

* Fatty acids
* High density lipoproteins
* Chylomicrons
* Low density lipoproteins
* Very low density lipoproteins
* Chylomicrons
A lipoprotein containing Apo48, Apo CII and ApoE would be a

* Chylomicron
* Chylomicron remnant
* VLDL
* LDL
* HDL
* Chylomicron
Which of the following is NOT a primary function of high density lipoprotein?

* Scavenge cholesterol from dying cells
* Transport fatty acids to the cells of the body
* Donate ApoCII to VLDLs
* Donate ApoE to chylomicrons
* Donate ApoE to VLDLs
* Transport fatty acids to the cells of the body
Which of the following is a bile acid?

* Chenodeoxycholic acid
* Mevallonic acid
* Phosphatidyl choline
* Coprostanol
* Lanosterol
* Chenodeoxycholic acid
Which of the following is a sympathetic effect on carbohydrate metabolism?

* Epinephrine directly stimulates glucose uptake by target cells
* Epinephrine stimulates the release of insulin
* Epinephrine stimulates glycogenolysis in the liver
* Epinephrine directly inhibits release of glucagon
* Glucose transport in the liver is dependent on the presence of epinephrine
* Epinephrine stimulates glycogenolysis in the liver
Sympathetic discharge to the gastrointestinal tract can produce

* Decreased motility
* Increased gastric secretion of HCl
* Increased pancreatic secretion
* Contraction of the gall bladder
* Relaxation of the external anal sphincter
* Decreased motility
Pancreatic alpha cells secrete

* Secretin
* Cholecystokinin
* Insulin
* Glucagon
* Carboxypeptidase
* Glucagon
The pH optimum for salivary lipase is quite acidic, indicating that

* the isoelectric point for the lipase is acidic
* the specific activity of the lipase is greatest at low pH
* the lipase is most soluble at low pH
* the lipase is denatured at high pH
* the lipase is inactive in the stomach
* the specific activity of the lipase is greatest at low pH
A decrease in hydrochloric acid secretion by the stomach would most affect

* Neutralization of stomach chyme
* Destruction of bacteria in the stomach
* Pepsin formation
* Non-enzymatic hydrolysis of dietary protein
* Stimulation of pancreatic secretions
* Pepsin formation
The primary saccharide entering the blood following carbohydrate ingestion is

* Glucose
* Sucrose
* Galactose
* Mannose
* Ribose
* Glucose
Which of the following effects does dietary fat have on gastric emptying?

* Fat stimulates enterogastrone release, which stimulates gastric emptying
* Fat stimulates enterogastrone release, which inhibits gastric emptying
* Fat initiates the enterogastric reflex, which inhibits gastric emptying
* Fat initiates the enterogastric reflex, which stimulates gastric emptying
* Fat inhibits secretin release, which decreases gastric emptying
* Fat stimulates enterogastrone release, which inhibits gastric emptying
Which of the following is NOT a key function of the liver?

* Drug metabolism
* Gluconeogenesis
* Plasma protein synthesis
* Digestive enzyme secretion
* Regulation of plasma glucose
* Digestive enzyme secretion
Increased flow from the gall bladder during feeding results in part from

* a conditioned reflex.
* the release of enterocrinin.
* the release of cholecystokinin.
* a reflex by way of the splanchnic nerve.
* the stimulatory effect of bile salts by way of the enterohepatic circulation.
* the release of cholecystokinin.
The enterogastric reflex produces

* an increase in gastric secretion.
* an increase in gastric motility.
* a decrease in gastric motility.
* a decrease in intestinal motility.
* an increase in intestinal motility.
* a decrease in gastric motility.
The most important function of hydrochloric acid in the stomach is

* destruction of bacteria.
* neutralization of chyme.
* activation of pepsinogen.
* hydrolysis of dietary protein.
* stimulation of pancreatic secretion.
* activation of pepsinogen.
By which of the following mechanisms does the presence of fats in the small intestine influence the rate of gastric emptying?

* Fat in the small intestine hastens gastric emptying through activity of the hormone, enterogastrone.
* Fat in the small intestine inhibits gastric emptying through the activity of enterogastrone.
* Fat in the small intestine initiates the enterogastric reflex that inhibits further gastric emptying.
* Fat in the small intestine initiates the enterogastric reflex that stimulates further gastric emptying.
* Fat in the small intestine inhibits gastric emptying through the activity of enterogastrone.
The function of rhythmic segmentation is chiefly that of

* macerating food.
* mixing food with digestive secretions.
* increasing the surface available for absorption.
* transporting material down the gastrointestinal tract.
mixing food with digestive secretions.
Secretin functions in digestion of proteins by increasing

* flow of bile.
* secretion of pepsin.
* flow of pancreatic juice.
* secretion of carboxypeptidase
* flow of pancreatic juice.
Neutralization of acids by saliva results mainly from which of the following salivary contents?

* Mucin
* Ammonia
* Carbonate
* Bicarbonate
* Amino acids
* Bicarbonate
After functioning in the small intestine, the largest portion of bile salts are

* excreted in the feces.
* reabsorbed into the central lacteal.
* destroyed by bacteria in the large intestine.
* reabsorbed into the portal circulation and reused.
* removed from the circulation by the kidneys and excreted in the urine.
* reabsorbed into the portal circulation and reused
Gastrointestinal hormones act on each of the following organs EXCEPT the

* stomach
* pancreas
* duodenum
* gallbladder
* urinary bladder.
* urinary bladder.
Parietal cells secrete

* Hydrochloric acid
* Alkaline mucous
* Pepsinogen
* Pepsin
* Secretin
* Hydrochloric acid
Which of the following is composed of skeletal muscle?

* pyloric sphincter
* ileocecal sphincter
* lower esophageal sphincter
* internal anal sphincter
* external anal sphincter
* external anal sphincter
The primary products of the pancreatic peptidases are

* amino acids
* dipeptides
* short chain polypeptides
* free fatty acids
* triglycerides
* dipeptides
The colon is primarily responsible for absorbing

* fatty acids
* amino acids
* monosaccharides
* water
* calcium
* water
Flatus

* occurs in men, but not in women
* consists primarily of hydrogen and methane
* is generated mainly from ingested oxygen and nitrogen
* is decreased when intestinal bacterial count is increased
* All of the above
* consists primarily of hydrogen and methane
In the Fed State

* Hepatic glucokinase will be active
* Adipocytes can use glucose for fatty acid synthesis
* Muscle cells will use glucose for glycogen synthesis
* Liver cells will be synthesizing fatty acids
* All of the above
* All of the above
The amount of absorption of dietary iron is primarily dependent on

* Vitamin B12
* Intrinsic Factor
* Degree of saturation of mucosal cells with iron
* Extent of iron secretion in the urine
* Concentration of hemoglobin in the blood
* Degree of saturation of mucosal cells with iron
Which salivary component is most important in neutralizing oral acidity?

* Mucin
* Bicarbonate
* Citrate
* Ammonia
* Statherin
* Bicarbonate
This vitamin requires the presence of Intrinsic Factor for dietary absorption

* Niacin
* Biotin
* Cobalamin
* Phylloquinone
* Retinol
* Cobalamin
Rhythmic segmentation is used to

* mix food with digestive secretions
* propel food through the digestive tract
* act as sphincters in compartmenting the digestive tract
* increase absorptive surface area for nutrient absorption
* empty the gall bladder in response to cholecystokinin secretion
* mix food with digestive secretions
Which hormone stimulates gall bladder contraction?

* Secretin
* Gastrin
* Epinephrine
* Cholecystokinin
* Calcitonin
* Cholecystokinin
Of the 800 mg of calcium ingested each day, the majority is

* excreted in the kidney
* incorporated into bone
* absorbed and secreted by the digestive tract
* never absorbed by the digestive tract
* sequestered in the sarcoplasmic reticulum of skeletal muscle cells
* absorbed and secreted by the digestive tract
A marked loss of body weight is observed following destruction of the hypothalamic feeding center because the

1) basal metabolic rate is increased
2) swallowing reflex is lost
3) efficiency of digestion and absorption of food is lowered
4) desire to ingest food is decreased

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 4 only
Esophageal peristalsis is coordinated by

1) the sympathetic nervous system
2) a myogenic pacemaker in the upper esophagus
3) enteric hormones
4) the medullary swallowing center

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 4 only
The time required for gastric emptying is decreased by

1) the presence of fat in the duodenum
2) the gastrocolic reflex
3) the enterogastric reflex
4) parasympathetic stimulation of the gastric musculature

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 4 only
The pacemaker activity which controls the rate of stomach peristaltic contractions is

1) inhibited by the hormone secretin
2) not influenced by the size of the meal consumed
3) stimulated by sympathomimetic agents
4) a property of the gastric muscularis externa

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 2 and 4
Segmenting movements of the small intestine musculature

1) have a rate which is affected by the presence of chyme in the intestine
2) are initiated by a myogenic pacemaker
3) are strong, even during fasting
4) have an amplitude which increases with vagal stimulation

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 2 and 4
Peristaltic muscle contractions of the small intestine

1) occur as promoted by the migrating myoelectric motor complex
2) constitute the main mixing action of the intestine
3) are independent of extrinsic innervation
4) have a rate controlled by a myogenic pacemaker

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1 and 3
Which of the following is/are produced by stomach mucosal cells or gastric glands?

1) Trypsinogen
2) Pepsinogen
3) Amylase
4) Mucus

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 2 and 4
Gastric secretions during the cephalic phase are

1) rich in both pepsinogen and hydrochloric acid
2) elicited by tasteful meals
3) mediated by the vagus nerve
4) quantitatively the most important

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1, 2 and 3
The parietal cell of gastric glandular epithelium has several interesting properties which include

1) Synthesis of pepsinogen
2) Active secretion of hydrogen ion
3) Mucus secretion
4) Significant carbonic anhydrase activity

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 2 and 4
Bile salts aid in the intestinal absorption of

1) Glycogen
2) Water-soluble vitamins
3) Maltose
4) Triglycerides

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 4 only
Pancreatic juice, rich in enzymes, is secreted

1) into the exocrine ducts of the pancreas
2) during the cephalic phase of digestion
3) in response to cholecystokinin
4) in response to vagal stimulation of the pancreas

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* All (1, 2, 3 and 4) are correct
Bile salts are important aids to digestion in the gastrointestinal tract because they

1) lubricate the lining of the intestinal tract
2) effect greater efficiency of lipase action
3) promote water absorption in the colon
4) form microemulsions with lipids

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 2 and 4
Source(s) of carbohydrate digesting enzyme(s) include

1) Saliva
2) Gastric secretions
3) Pancreatic exocrine secretions
4) Bile

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1, 2 and 3
After removal of the pancreas all of the following enzymes having digestive action in the small intestine would be lost EXCEPT

1) Lactase
2) Carboxypeptidase
3) Sucrase
4) Chymotrypsin

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1 and 3
Salivary amylase digestion of starch in the gastric lumen

1) produces mainly maltose
2) is favored by an acidic pH (less than 4)
3) is similar to pancreatic amylase digestion of starch in the intestinal lumen
4) results in maltose digestion by stomach epithelial cells

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1 and 3
Of the following digestive enzymes, which is (are) located on the brush border of small intestine mucosal cells?

1) Maltase (glucoamylase)
2) Sucrase
3) Dipeptidase
4) Enterokinase

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1, 2 and 3
Major end products of pancreatic lipase digestion of dietary triglycerides include

1) Fatty acids
2) Diglycerides
3) Monoglycerides
4) Chylomicrons

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* All (1, 2, 3 and 4) are correct
* 1 and 3
1) Volume of gastric acid secretion during the cephalic phase of secretion
2) Volume of gastric secretion during the gastric phase of secretion

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 2 is greater than 1
1) Concentration of bile salts in the gall bladder
2) Concentration of bile salts in the hepatic ducts

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 is greater than 2
1) Daily net absorption of water from the jejunum
2) Daily net absorption of water from the colon

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 is greater than 2
1) Digestion of protein to amino acids in the gastric lumen
2) Digestion of protein to amino acids in the small intestine

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 2 is greater than 1
1) Daily net absorption of monosaccharides into portal venous blood
2) Daily net absorption of monosaccharides into the lymphatic circulation

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 is greater than 2
1) Intragastric pressure during parasympathetic stimulation of stomach musculature
2) Intragastric pressure during sympathetic stimulation of stomach musculature

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 is greater than 2
1) Time required to empty the stomach after ingestion of a high-fat meal
2) Time required to empty the stomach after ingestion of an isocaloric low-fat meal

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 is greater than 2
1) Maximal gastric hydrochloric acid secretory capacity of a normal person
2) Maximal gastric hydrochloric acid secretory capacity of a duodenal ulcer patient

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 and 2 are approximately equal
1) Tonicity of stomach venous blood during normal basal conditions
2) Tonicity of stomach venous blood during active secretion of hydrochloric acid by gastric glands

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 2 is greater than 1
1) Rate of basic electric rhythm of gastric smooth muscle of the empty stomach
2) Rate of basic electric rhythm of gastric smooth muscle of the full stomach

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 and 2 are approximately equal
1) Daily net absorption of triglycerides into portal venous blood
2) Daily net absorption of triglycerides into the lymphatic circulation

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 2 is greater than 1
1) Absorptive capacity for Vitamin B12 by the stomach
2) Absorptive capacity for Vitamin B12 by the duodenum

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 and 2 are approximately equal
1) Excretion of cholesterol into bile
2) Excretion of cholesterol into urine

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 1 is greater than 2
1) Digestion of maltose in the gastric lumen
2) Digestion of maltose by microvilli of the small intestine

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 2 is greater than 1
1) Daily net absorption of bile salts by the duodenum and jejeunum
2) Daily net absorption of bile salts by the lower ileum

* 1 is greater than 2
* 2 is greater than 1
* 1 and 2 are approximately equal
* 2 is greater than 1
Item: Coordinated by the medullary swallowing center

1) Upper esophageal sphincter
2) Lower esophageal sphincter

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with both (1) and (2)
Item: Relaxation is inhibited in achalasia

1) Upper esophageal sphincter
2) Lower esophageal sphincter

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (2) only
Item: Tension is relaxed during the vomiting reflex

1) Upper esophageal sphincter
2) Lower esophageal sphincter

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with both (1) and (2)
Item: Vomiting reflex

1) Medullary control
2) Myogenic pacemaker

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (1) only
Item: Small intestinal segmentation

1) Medullary control
2) Myogenic pacemaker

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2
* The Item is associated with (2) only
Item: Swallowing movements

1) Medullary control
2) Myogenic pacemaker

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (1) only
Item: Gastric peristaltic contractions

1) Medullary control
2) Myogenic pacemaker

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (2) only
Item: Defecation reflex

1) Medullary control
2) Myogenic pacemaker

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (1) only
Item: High concentration of carbonic anhydrase

1) Stomach parietal cells
2) Pancreatic intercalary duct cells

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with both (1) and (2)
Item: Produce proteolytic enzyme secretion

1) Stomach parietal cells
2) Pancreatic intercalary duct cells

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with neither (1) nor (2)
Item: Intrinsic factor

1) Stomach parietal cells
2) Pancreatic intercalary duct cells

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (1) only
Item: Gastric digestion of dietary protein

1) Pepsin
2) Trypsin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (1) only
Item: Enterokinase activation

1) Pepsin
2) Trypsin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (2) only
Item: Conversion of starch to maltose

1) Pepsin
2) Trypsin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with neither (1) nor (2)
Item: Capable of autocatalytic activation

1) Pepsin
2) Trypsin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with both (1) and (2)
Item: Secretion of inactive precursor is increased during the cephalic phase of digestion

1) Pepsin
2) Trypsin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with both (1) and (2)
Item: Synthesized by gastric antral mucosa

1) Secretin
2) Cholecystokinin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with neither (1) nor (2)
Item: Stimulates pancreatic bicarbonate production

1) Secretin
2) Cholecystokinin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (1) only
Item: Stimulates gall bladder contraction

1) Secretin
2) Cholecystokinin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with (2) only
Item: Synthesized by duodenal mucosal epithelium

1) Secretin
2) Cholecystokinin

* The Item is associated with (1) only
* The Item is associated with (2) only
* The Item is associated with both (1) and (2)
* The Item is associated with neither (1) nor (2)
* The Item is associated with both (1) and (2)
Destruction of the ventral-medial nuclei of the hypothalamus produces obesity. The increase in body weight is the result of:

1) Increased muscle mass
2) Higher efficiency of energy conservation
3) Physical inactivity
4) Increased consumption of food

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 4 only
Gastric motility is decreased

1) During chewing and swallowing of a meal
2) In response to secretin released by the duodenal mucosa
3) When fat is present in the duodenal contents
4) As a result of stretching of the gastric musculature

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 1, 2 and 3
Peristaltic contractions of muscle occur in the human

1) esophagus
2) stomach
3) small intestine
4) large intestine

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 1, 2, 3 and 4
During the vomiting reflex

1) gastric contents are forced through the esophagus by reverse peristalsis
2) the stomach, with the exception of the pyloric antrum, is relaxed
3) both the glottis and hypopharyngeal sphincter are relaxed
4) forceful contractions of abdominal muscles compress the stomach

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 2 and 4
Chyme is propelled along the intestine in a caudal (rectal) direction by way of

1) Intestino-intestinal reflex
2) Gastro-ileal reflex
3) Movements of the villi
4) Peristaltic contractions

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 2 and 4
Stomach secretions during the gastric phase of digestion are

1) quantitatively more than during the cephalic phase
2) mediated by the hormone gastrin
3) stimulated by the presence of bulk in the stomach
4) enhanced by the hormone secretin

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 1, 2 and 3
The plasma alkaline tide which is associated with gastric acid secretion is due to

1) movement of bicarbonate ion into plasma
2) loss of plasma chloride ion
3) uptake of plasma carbon dioxide by the parietal cell
4) development of plasma hypotonicity

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 1 and 3
Which of the following are absorbed in the jejunum?

1) Intrinsic factor
2) Water
3) Bile salts
4) Monosaccharides

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 2 and 4
Amino acids are the major product of which of the following proteolytic enzymes?

1) Pepsin
2) Enterokinase
3) Trypsin
4) Carboxypeptidase

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 4 only
Bile salts aid in the intestinal absorption of

1) Starch
2) Fat-soluble vitamins
3) Protein
4) Monoglycerides

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 2 and 4
Glucose units make up the structure(s) of

1) Amylose
2) Glycogen
3) Amylopectin
4) Maltose

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 1, 2, 3 and 4
During absorption, which of the following move into the intestinal blood capillary system?

1) Triglyceride
2) Amino acids
3) Phospholipid
4) Glucose

* 1, 2 and 3
* 1 and 3
* 2 and 4
* 4 only
* 1, 2, 3 and 4
* 2 and 4
Item: Swallowing movements

(1) Medullary control
(2) Myogenic pacemaker

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (1) only
Item: Gastric peristaltic contractions

(1) Medullary control
(2) Myogenic pacemaker

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (2) only
Item: Small intestine segmenting movements

(1) Medullary control
(2) Myogenic pacemaker

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (2) only
Item: Gall bladder contraction

(1) Gastrin
(2) Cholecystokinin

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (2) only
Item: Synthesized by duodenal mucosal epithelium

(1) Gastrin
(2) Cholecystokinin

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (2) only
Item: Stimulation of hydrochloric acid secretion

(1) Gastrin
(2) Cholecystokinin

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (1) only
Item: Micelle formation

(1) Bile salts
(2) Vitamin B12

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (1) only
Item: Absorption in the ileum

(1) Bile salts
(2) Vitamin B12

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with BOTH (1) and (2)
Item: Intrinsic Factor

(1) Bile salts
(2) Vitamin B12

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (2) only
Item: Gastric digestion of carbohydrate

(1) Pepsin
(2) Trypsin

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with NEITHER (1) nor (2)
Item: Release stimulated during the cephalic phase of digestion

(1) Pepsin
(2) Trypsin

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with BOTH (1) and (2)
Item: Inactive form synthesized by the pancreas

(1) Pepsin
(2) Trypsin

* The item is associated with (1) only
* The item is associated with (2) only
* The item is associated with BOTH (1) and (2)
* The item is associated with NEITHER (1) nor (2)
* The item is associated with (2) only
The hormone secretin aids in protein digestion by stimulating

* Bile flow
* Pepsin secretion
* Pancreatic secretion
* Carboxypeptidase secretion
* Relaxation of the pyloric sphincter
* Pancreatic secretion
Which salivary component helps to neutralize acidity in the mouth?

* Statherin
* Mucin
* Bicarbonate
* Potassium
* Chloride
* Bicarbonate
What is the fate of most bile salts after their secretion into the small intestine?

* Reabsorption in the portal circulation and eventual reuse by the liver
* Reabsorption in the central lacteal and excretion in the urine
* Excretion in the feces
* Destruction by bacteria in the large intestine and excretion as bilirubin
* Conversion to biliverdin in the small intestine, followed by excretion in the feces
* Reabsorption in the portal circulation and eventual reuse by the liver
Digestion of sucrose by sucrase yields

* Glucose only
* Glucose and galactose
* Glucose and fructose
* Galactose and fructose
* Fructose and maltose
* Glucose and fructose
Which of the following is NOT a function of the liver?

* Bile synthesis
* Urea elimination
* Drug conjugation
* Carbohydrate storage
* Prothrombin synthesis
* Urea elimination
Which of the following is NOT a target of a gastrointestinal hormone?

* Stomach smooth muscle
* Pancreas
* Duodenal smooth muscle
* Gallbladder
* Urinary bladder
* Urinary bladder
After removal of the pancreas all of the following enzymes having digestive action in the small intestine would be lost EXCEPT

* Lipase
* Carboxypeptidase
* Maltase
* Ribonuclease
* Trypsin
* Ribonuclease
The major end product of amylase digestion of plant starch by pancreatic amylase in the small intestine is

* Glucose
* Fatty acids
* Sucrose
* Maltose
* Leucine
* Maltose
Segmenting contractions of the small intestine musculature

* are initiated by a myogenic pacemaker
* have an amplitude which is not affected by the presence of chyme
* have a rate which increases with vagal stimulation
* are strong, even during fasting
* constitute the main oral to caudal propulsive action for chyme movement
* are initiated by a myogenic pacemaker
Destruction of the ventrolateral nuclei of the hypothalamus (Feeding Center) results in severe loss of body weight because the

* swallowing reflex is lost
* desire to ingest food disappears
* basal metabolic rate is increased
* efficiency of digestion and absorption of food is lowered
* rate of urine formation is increased, causing loss of body water
* desire to ingest food disappears
Stomach secretions during the gastric phase of secretion are

* enhanced by secretin
* quantitatively less than during the cephalic phase of secretion
* mediated by the hormone gastrin
* decreased by proteolytic digestive products
* lacking in hydrochloric acid content
* mediated by the hormone gastrin
Haustral contractions are segmenting type movements of the

* Esophagus
* Stomach
* Duodenum
* Ileum
* Colon
* Colon
Peristaltic contractions of small intestine smooth muscle

* Have a rate controlled by a myogenic pacemaker
* Occur in response to stretch
* Move chyme quickly (greater than 10 cm/sec)
* Constitute the main mixing action of the intestine
* Are strong, even during fasting
* Occur in response to stretch
In animals, satiety appears to be a function of

* Systemic blood pressure
* Plasma sodium concentration
* Extracellular glucose concentration
* Extracellular fluid volume
* Blood protein content
* Extracellular glucose concentration
Carbohydrate digesting enzymes are found in

* Colonic secretions
* Bile
* Saliva
* Brunner’s gland secretions
* Pancreatic endocrine secretions
* Saliva
The major product(s) of pancreatic lipase digestion of dietary triglycerides is(are)

1. Acetate
2. Monoglycerides
3. Glycerol
4. Free fatty acids

* 1, 2 and 3 only
* 1 and 3 only
* 2 and 4 only
* 4 only
* 1, 2, 3 and 4
* 2 and 4 only
Salivary amylase digestion of starch in the gastric lumen

1. is favored by a neutral pH
2. is similar to pancreatic amylase action in the intestinal lumen
3. produces mainly maltose
4. results in glucose absorption by stomach epithelial cells

* 1, 2 and 3 only
* 1 and 3 only
* 2 and 4 only
* 4 only
* 1, 2, 3 and 4
* 1, 2 and 3 only
During absorption, which of the following does NOT move into the intestinal blood capillary system?

1. Triglycerides
2. Amino acids
3. Cholesterol
4. glucose

* 1, 2 and 3 only
* 1 and 3 only
* 2 and 4 only
* 4 only
* 1, 2, 3 and 4
* 1 and 3 only
2. Smooth muscle cells
Depend on calcium from the sarcoplasmic reticulum for contraction
Use actin-calmodulin crossbridges to shorten
Regulate contraction using troponin and tropomyosin
Display a broader length-tension curve than do skeletal muscles
Display a broader length-tension curve than do skeletal muscles
3. During a normal isotonic contraction
Only the A band shortens
Both the A and H band shorten
Both the I and H band shorten
Only the I band shortens
Both the A and I band shorten
Both the I and H band shorten
4. Botulinum toxin exerts its effects by
Binding to ? adrenergic receptors
Stimulating monoamine oxidase
Stimulating acetylcholine esterase activity
Inhibiting exocytosis of ACh
Inhibiting high-affinity reuptake of choline
Inhibiting exocytosis of ACh
5. Place the following events in the order in which they would occur following an increase in activity of excitatory cerebellar neurons:
1) Increased ?-motoneuron activity
2) Increased ?-motoneuron activity
3) Increased Ia afferent activity
4) Contraction of intrafusal fibers
5) Contraction of extrafusal fibers
1, 5, 3, 2, 4
2, 5, 1, 3, 4
2, 4, 3, 1, 5
1, 4, 2, 5, 3
3, 4, 2, 1, 5
1, 5, 3, 2, 4
10. The t-tubules in skeletal muscle cells
Must be intact for a muscle to develop significant tension
Are stimulated by foot processes
Are present for extracellular calcium to gain rapid access to sarcomeres
Stimulate the release of calcium from mitochondria
All of the above
Must be intact for a muscle to develop significant tension
11. A drug which allows ATP to bind to thick filaments but which blocks ATP hydrolysis will
Produce a situation like rigor mortis
Produce increased tension per action potential
Cause calcium to be returned to the sarcoplasmic reticulum
Produce flaccid paralysis
All of the above
Produce flaccid paralysis
12. Muscle fatigue results because
The muscle has shortened too far beyond Lo
Stimulation frequency has decreased
ACh has been depleted in nerve terminals
ATP levels have fallen
None of the above
ATP levels have fallen
13. Synaptic transmission at the skeletal neuromuscular junction:
Produces an end plate potential which can be summated to reach threshold for muscle contraction
Sometimes uses the transmitter norepinephrine
May be excitatory or inhibitory
Generally produces one muscle action potential for each neuronal action potential
None of the above
Produces an end plate potential which can be summated to reach threshold for muscle contraction
15. Which of the following drugs would act to counter the effect of curare at the neuromuscular junction?
Norepinephrine
Gallium
Succinylcholine
Physostigmine
Physostigmine
2. The energy substrate of critical importance in the prevention of muscular fatigue is
ATP
Phosphocreatine
Glycogen
Oxygen
Fat
ATP
3. In order for muscles to gain strength they must be
Isometrically exercised
Loaded with glycogen
Overloaded
Exercised at least twice per week
Worked to exhaustion
Overloaded
4. The main disadvantage of isometric muscular training is
training takes place over a limited range of motion
the equipment is too expensive
no strength gains are seen with this form of exercise
it leads to muscle injury
it requires too much energy
training takes place over a limited range of motion
5. One of the problems encountered with glycogen loading is
Water retention
Dental decay
Development of Type II diabetes
Insulin reactions
Acidosis
Insulin reactions
6. If two runners of different body weights run a mile in the same amount of time, which runner will expend the most energy?
The faster runner
The heavier runner
The lighter runner
Both runners expend the same amount of energy
The heavier runner
7. How many kilocalories of energy must be expended to lose one pound of fat?
10,000
5,000
3,500
2,500
1,000
3500
18. Which of the following forms of training gives the greatest gains in strength in the shortest period of time?
Isokinetic training
Isotonic Nautilus Machine training
Isotonic free weight training
Isometric training
Isotonic Nautilus Machine training
26. In order to develop a free weight program that concentrates on the development of strength it would be necessary to
use a higher repetition maximum
use light weights
have a long rest period between sets of exercise
use a lower repetition maximum
use a lower repetition maximum
28. The primary factor causing fatigue due to muscular work is
Reduced muscle glycogen stores
Lactic acid accumulation
Muscular pain
Reduced fat stores
Muscular pain