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90 Cards in this Set
- Front
- Back
why something happens & what's the big picture
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teleological approach to physiology
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how something happens
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mechanic approach to physiology
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mediates exchange of materials btwn cells and environment
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ECF
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the ability of the body to maintain a relatively constant internal environment
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homestasis
- it is DYNAMIC |
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what are some examples of parameters that homeostasis is in control of
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- environmental (temperature, pH)
- materials cell needs (nutrients, water, Na, Ca, ions) - internal secretions (hormones) |
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3 cavities of body
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1. cranial
2. thoracic 3. abdominal - organismal level of compartmentation |
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signalling molecule released in bloodstream & acts on target cells in distance
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hormone
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neurocrine released by neuron into blood & acts on distant target cells
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neurohormones
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acts more slowly than NTs & act in autocrine & paracrine signals
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neuromodulator
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chemical signal secreted by neuron
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neurocrine
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cannon's postulates are:
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1. nervous system has a role in preserving the fitness of internal environment
2. some systems of body are under tonic control 3. some systems of body are under antagonistic control 4. 1 chemical signal can have different effects in diff tissues |
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control that can be varied up or down by same effector
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tonic control
ex) volume on ipod |
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type of control where 2 regulators w/ opposite effects on same variable
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antagonistic control
3x) heating & air |
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paracrine & autocrine are ___ control
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local
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nervous & endocrine is __ control
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reflex
- long distances |
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the ___ ___ evaluates signal & compares it to a set point & initiates response
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integrating center
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a change in a regulated variable
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stimulus
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___ monitors the variable& sends info to integrating center
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sensor/ receptor
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true or false- endocrine signals last longer than nervous system
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true
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in endocrine signalling the efferent signalling is a
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hormone
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neuroendocrine reflexes have how many integrating centers?
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2 or more
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these are classified chemically as peptides, steroids, or amines
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hormones
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__ hormones bind to membrane receptors
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peptide
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__ hormones are derived from cholesterol
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steroid
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steroid hormones in adrenal cortex are
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cortisol & aldosterone
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steroid hormone in ovary
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estradiol
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___ hormones bind to cytoplasmic receptors
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steroid
- most are bound to steroid plasma protein carriers - receptors are in cytoplasm or nucleus |
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what are 3 catecholamine hormones
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1. dopamine
2. norepinephrine 3. epinephrine |
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what is an example of a thyroid hormone
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1. thyroxine
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__ is an amine hormone derived from the amino acid tryptophan
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melatonin
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what are the 2 tyrosine derivative hormones
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1. catecholamines
2. thyroid hormones |
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___ pituitary is an extension of the neural tissue
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posterior
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___ pituitary is a true endrocrine gland of epithelial origin
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anterior
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– controls ejection of milk during breastfeeding
– Stimulates uterine contractions during labor – other possible modulatory functions in the brain |
oxytocin
- posterior pituitary |
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– regulates water balance (promotes water reabsorption)
– Target tissue is kidney – also called antidiuretic hormone (ADH) |
vasopressin
- posterior pituitary |
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every anterior pituitary hormone is a trophic hormone except for ___
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prolactin
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the hypothalamic-hypophyseal portal system is used for what hormones
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anterior pituitary
- |
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The combination of
hormones produces a result that is greater than additive. |
synergism
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One hormone cannot fully exert its effects unless a
second hormone is present is called |
permissiveness
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2 parts of periphral nervous system:
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afferent & efferent
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2 parts of efferent nervous system
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autonomic (smooth muscle, cardiac muscle, somatic (skeletal muscle)
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CNS is made of
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brain & spinal cord
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2 parts of autonomic system
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1. parasympathetic
2. sympathetic - many shared targets usually antagonistic |
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functional unit of the nervous system
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neuron
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space between axon terminal and target cell
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synaptic cleft
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__ neurons are afferent neurons
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sensory
- pseudounipolar & bipolar |
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___ neurons are in the CNS
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interneurons
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__ neurons go from CNS to effectors
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efferent
- ex) motor |
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__ nerves are both sensory & motor axons
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mixed
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cluster of nerve cell bodies in the PNS
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ganglion
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cluster of nerve cell bodies in CNS
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nucleus
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neurocrines are __ from axon terminal & ___ in cell body
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secreted; synthesized
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true or false- glial cells are only used for support cells
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true
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50% of all cells in brain are ___
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astrocytes
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what kind of cells form the myelin sheath
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schwann cells, oligodendrocytes
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the net amount of electrical charge produced by any process is 0
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law of conservation of electrical charge
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material that allows separated positive & negative charges to move freely toward each other
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conductor
- ex) water, cytoplasm |
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material that prevents separated charges from moving toward each other
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insulator
ex) phospholipid bilayer |
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flow of electrical charge carried by
an ion |
current
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The direction of ion movement depends on
the ___ ___ for the ion. |
electrochemical gradient
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amplitude (strength) is variable & depends on strength of initial stimulus
• Small stimulus creates small graded potential • Voltage change may be in either direction- depolarizing or hyperpolarizing • Usually ions involved: Na+, Cl-, and Ca2+ |
graded potential
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true or false- graded potentials can add up
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true
- can also be inhibitory |
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– A second action potential cannot be triggered regardless of
the strength of the stimulus – Basis: time required for Na+ channel gates to reset – Implications: Action potentials cannot overlap and cannot travel backward. |
absolute refractory period
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– A stronger than normal depolarizing graded potential is
required to reach threshold and trigger an action potential, which may be smaller than normal – Basis: some (but not all) Na+ channels have reset, K+ channels are still open |
relative refractory period
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• Autoimmune disease –more common in women
• Antibodies destroy myelin sheath around neurons in CNS • So K+ leaks out of cell through voltage-gated K+ channels- causes cells to become hyperpolarized (cell will require bigger potential to reach AP) • Symptoms: muscle weakness, fatigue, decrease in coordination, paralyzed • No cure |
MS
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• Demyelinating autoimmune disease
• Affects sensory & motor neurons in PNS • Very rapid onset – can be paralyzed within a weak • Can recover from it |
Guillain-Barre Syndrome
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axon terminal of neuron sending the signal
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presynaptic cell
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bind to NT and initiate some sort of response
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postsynaptic cell
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__ is made from acetyl-CoA & choline
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acetylcholine
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acetylcholine has 2 types of cholinergic receptors:
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nicotinic & muscarinic
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True or false- Norepinephrine (NE)- can be used as a NT, epinephrine cannot
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true, it can only be used as a neurohormone
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one controlling neuron coordinating a response is called
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divergence
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when a neuron receives info from multiple pre-synaptic cells when they converge on 1 post-synaptic cells
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convergence
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layer of meninges thick protective layer associated w/ veins that collect blood from brain through sinuses
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duramater
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true or false- In most regions, blood is kept separate from
neural tissue by the blood-brain barrier |
true
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____ fluid is inside the pia mater
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Interstitial
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___ is in ventricles and subarachnoid space
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CSF
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spinal cord divided into 2 areas-
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white matter & gray matter
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__ matter in spinal cord is unmyelinated & contains interneurons
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gray
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__ matter in spinal cord is myelinated & runs to/from the brain & between different parts of spinal cord
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white
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a __ reflex initiates a response w/o input from the brain
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spinal reflex
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___ is in charge of involuntary
functions (e.g., blood pressure, breathing, swallowing, vomiting |
medulla oblongata
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___ is in charge of information relay point between
cerebrum and cerebellum; control of breathing |
pons
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___ is in charge of eye movement
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midbrain
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__ is in charge of sleep/arousal, muscle tone, breathing, BP, pain
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reticular formation
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rest and digest is what branch of autonomic division
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parasympathetic
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fight or flight is what branch of autonomic division
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sympathetic
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major areas of limbic system:
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amygdala, cingulate gyrus, hippocampus
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amygdala & cingulate gyrus are linked to:
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emotion & memory
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hippocampus is associated with:
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learning & memory
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