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12 Cards in this Set
- Front
- Back
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Leptin is a ___ hormone that is produced by ____
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Leptin is a peptide hormone produced by adipose tissue that plays a role in regulating long term energy intake and expenditure
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Orexigenic
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(Orexis = appetite {Gr.}) = Stimulates appetite
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Anorexigenic
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Orexis = appetite
Anorexigenic = Inhibits appetite |
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Where does leptin act and what is it's effect on appetite>
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Activates anoretic cells/neurons to release Melanocortins (αMSH/CART)
Inhibits orexigenic cells/neurons from releasing NPY/AgRP acts in the medial hypothalamus to inhibit appetite |
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when there is sufficient fat stores, adipose secretes Leptin which stimulates the medial hypothalamus to secrete what hormones to suppress appetite?
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leptin stimulates medial hypothalamus to release Melanocortins (αMSH/CART) to suppress appetite.
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when there is sufficient fat stores, adipose secretes Leptin which with Grelin inhibits the medial hypothalamus from secreting what hormones that stimulate appetite?
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Leptin and Grelin inhibits the medial hypothalamus from releasing NPYto prevent appetite stimulation.
AgRP blocks αMSH receptor binding |
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Stimulate appetite = orexigenic
name 5 |
1) Neuropeptide Y (NPY)
2) Agouti related peptide (AgRP) 3) Ghrelin 4) Cortisol 5) Endocannabinoids |
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Inhibit appetite = anorexigenic
name 5 |
1) Melanocortins (αMSH/CART)
2) Insulin 3) Leptin 4) Glucagon-like peptide-1 (GLP-1) 5) Cholecystokinin (CCK) |
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Which hypothalamic neurotransmitter acts as an endogenous antagonist of the melanocortin receptor?
1) CART 2) NE 3) AgRP 4) α-MSH 5) NPY |
AgRP acts as an endogenous antagonist of the melanocortin receptor and block αMSH from binding
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Which hypothalamic neurotransmitters release is stimulated by Leptin?
1) CART 2) NE 3) AgRP 4) α-MSH 5) NPY |
Melanocortins (αMSH/CART)
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Which hypothalamic neurotransmitters release is inhibited by Leptin?
1) CART 2) NE 3) AgRP 4) α-MSH 5) NPY |
NPY release is inhibited by Leptin
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Which hypothalamic neurotransmitter acts as an endogenous agonist of the melanocortin receptor?
1) CART 2) NE 3) AgRP 4) α-MSH 5) NPY |
α-MSH is a MC4 agonist and inhibits feed behabior
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