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5 Cards in this Set
- Front
- Back
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What is made in the adrenal medulla?
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Catecholamines: epinephrine and norepinephrine
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What is a simplified way to think about the medulla?
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An enormous sympathetic ganglion where the postganglionic neurons have lost their axons and just become huge secretory cells. -- CHROMAFFIN CELLS
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What is the catecholamine synthesis pathway?
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Tyrosine --> Phenylalanine --> Dopamine --> Norepinephrine --> Epinephrine
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What are the different catecholamine receptors?
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Alpha Receptors – NE > E > Isoproterenol
- Beta-1 Receptors – Isoproterenol >> E ~ NE - Beta-2 Receptors – Isoproterenol >> E > NE aka ALPHA receptors are more sensitive to Norepinephrine BETA-1 don't prefer either BETA-2 prefer Epinephrine |
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What is Pheochromocytoma?
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Chromaffin cell tumor, is rare fatal HTN. Use alpha and beta blockers.
Unopposed alpha receptor action will kill you. |
