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20 Cards in this Set

  • Front
  • Back
Extrinsic controlers of arteriolar radius
1) Neuronal - Symp keeps neruogenic tone w/ NE -
2) Hormonal - catecholamines, angiotensin, vasopressin
adrenal meduallary catecholamines
- release epi (some NE) in response to symp-ex which get B1 in heart - get a-adr at high plasma levels (good for shock in ER)
from renal - increase SVR, decrease venous CPL to support MAP at or above normal
from posterior pituitary - constrictor - released w/ decreased CVP, hemmorhage, dehydration
dq/dt (diffusion rate) =
Perm * SA * [grad/l]
CFR (cap filtration rate) =

where COPp and Pc are most imp
filtration and resorption w/
COPp and Pc
if COPp < Pc, filtration
if COPp > Pc, resporption
Determinants of ultrafiltration
1) COP (usually constant)
2) Kf (inflam can change)
3) Pc - directly related ot Pv, but constrict arterioles, decrease Pc
Coronary Circulation
- all caps perfused
- determinants of O2 demand - preload, afterload, CTY, HR
- determinants of Q - RV diameter, diastole P and duration (directly)
Control of Coronay vascular R and Q
- Intrinsic - metabolism things like adenosine, CO2, H, NO will dilate - dominates over extrinsic
- Extrinsic - neural things like symp - gets coronary less than others (dont restrict Q!)
Cerebral Blood Flow determinants
- can only increase 2X - must keep CSF, ISF, and BV constant
- Arterial P - main one
- Resistance vessels - intrinsic over extrinsic like heart
- Intracranial P (inverse)
- Venous P not sig
- Blood PCO2 (direct)
Pulmonary circulation and determinants
- in series w/ L and R hearts
- low P (no filt), R - high Q, CPL
- no myogenic behavior
- determined by passive control, PO2, little symp nerves (NE and CATs decrease CPL so higher SV wont cause dilation)
SNS in primary MAP reflex
- increase SVR (consrict) get a to constrict, b to dilate
- constrict VSM to decrease CPL
- Gets SA node to increase HR
- increase CTY and SV
- gets adrenal cells to increase NE
PNS in primary MAP reflex
mainly does HR (only gets SA, atria, and AV - NO his, purkinjie or ventricles) - via vagus that hits muscarine M2
- nerve endings in carotid sinus and aortic arch sense stretch - Af 9 and 10, ef symp and vagus
- increase BP, vagal discharge and decrease symp (for MAP) - takes secondes
- MAP decrease -> kidney give out renin and AII, pit does vasopressin - take minutes
Cardio Pulmonary Low-P baroreflex (aka Henry-Gauer reflex)
- supports ABR and regulates BV
- receptors on vena cava and R atrium - fire IRT stretch throught vagus and hit medulla - decrease CVP, and decrease vagus firing - also does ADH and renin for water and Na retention
Arterial Chemoreflex
- 2 MAP reflex
- Peripheral (carotid, aortic) and central (indirect) chemoreceptors sense PO2, PCO2, and Ph and respond w/ RR and symp to change MAP
Cerebral Ischemic Reflex
- 2 MAP reflex
- If MAP below 50, CBF will decrease enought to cause strong symp from medullary vasomotor center
Cushing Reflex
- 2 MAP reflex
- If extravascular intracranial P increases, CBF decreases -> ischemia in medulla -> vasomotor center stium -> symp - signs are high BP, low RR and HR
CR stiumlation vs baroreflex stiumlation
- if both stiumlated, baroreflex dominate
- if CR coupled to baroreflex inhibition, CR will increase symp