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26 Cards in this Set

  • Front
  • Back
Na +
Plasma - 142
ECF - 145
ICF - 15
K +
Plasma - 4.4
ECF - 4.5
ICF - 120
Ca 2+
Plasma - 1.2
ECF - 1.2
ICF - 10^-4
Cl -
Plasma - 102
ECF - 116
ICF - 5-20
Plasma - 291
ECF - 290
ICF - 290
cardiac glycosides
inhibit Na/K pump - increase streangth of cardiac contration -
PM Ca-ATPase
transport one - high affinity - good when ICF concentration is low - fewer than Na/k pumps
high affinity so good when ICF concentration is low - more than na/k pumps so higher capactiy
Na/Ca pump
Na in, Ca out - low affinity, high in # - good in high concentration
symporter - both in
Na/k/Cl pump
all in - loop of henle
Na/Cl pump
both in - renal distal tube
Na/H pump
both in - to raise IC pH
Nernst Equation
Ex = (60/z)*log([xout]/[xin])

z is valence
Cardiac Gylcosides
how they work
decrease Na gradient (its not going out of cell) - so SERCA and PM Ca pumps are preferred to Na/Ca - SERCA causese increase in SR lumen - so more Ca released in contraction
NT that causes EPSP in CNS
causes ISPS - Cl selective - big in CNS
non-depolarization blockers
stuff w/ curare in the name
depolarization blockers
Phase 4
Electrical and Mechanical Diastole - RP at 85 mV - IR K channels open to hold MP there
IR K channels
open at MPs less than -70 - if it gets higher, they are blocked by Mg - hold cell at RP and allow slight efflux
Phase 0
Onset of electrical systole - rapid depolarization by Na channels (MP goes toward Ena) can over-power IRK, then you get your + feedback
Phase 1
Beginning of Mechanical systole - partial repol as Na channels begin to inactiviate - Ito K channels open (efflux) to repol and Ca channels activate - all this makes it go near 0
Ito K channls
transient outward K channels - force membrane potential back to RP
Phase 2
E and M systole - slow Ca's open in response to phase 1 depol to keep MP depolartized (K's open too!) - Ca influx causes SR release and contraction - Ito Ks inactivate but DRK's activate to keep the K conductance high
Phase 3
End of E systole - Repol - all DRKs open up, Ca channels inactivatied