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26 Cards in this Set
- Front
- Back
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Na +
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Plasma - 142
ECF - 145 ICF - 15 |
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K +
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Plasma - 4.4
ECF - 4.5 ICF - 120 |
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Ca 2+
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Plasma - 1.2
ECF - 1.2 ICF - 10^-4 |
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Cl -
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Plasma - 102
ECF - 116 ICF - 5-20 |
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Osmolality
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Plasma - 291
ECF - 290 ICF - 290 |
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cardiac glycosides
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inhibit Na/K pump - increase streangth of cardiac contration -
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PM Ca-ATPase
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transport one - high affinity - good when ICF concentration is low - fewer than Na/k pumps
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SERCA Ca-ATPase
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high affinity so good when ICF concentration is low - more than na/k pumps so higher capactiy
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Na/Ca pump
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Na in, Ca out - low affinity, high in # - good in high concentration
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Na/glucose
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symporter - both in
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Na/k/Cl pump
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all in - loop of henle
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Na/Cl pump
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both in - renal distal tube
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Na/H pump
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both in - to raise IC pH
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Nernst Equation
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Ex = (60/z)*log([xout]/[xin])
z is valence |
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Cardiac Gylcosides
how they work |
decrease Na gradient (its not going out of cell) - so SERCA and PM Ca pumps are preferred to Na/Ca - SERCA causese increase in SR lumen - so more Ca released in contraction
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Glutamate
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NT that causes EPSP in CNS
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GABA
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causes ISPS - Cl selective - big in CNS
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non-depolarization blockers
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stuff w/ curare in the name
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depolarization blockers
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succinylcholine
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Phase 4
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Electrical and Mechanical Diastole - RP at 85 mV - IR K channels open to hold MP there
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IR K channels
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open at MPs less than -70 - if it gets higher, they are blocked by Mg - hold cell at RP and allow slight efflux
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Phase 0
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Onset of electrical systole - rapid depolarization by Na channels (MP goes toward Ena) can over-power IRK, then you get your + feedback
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Phase 1
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Beginning of Mechanical systole - partial repol as Na channels begin to inactiviate - Ito K channels open (efflux) to repol and Ca channels activate - all this makes it go near 0
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Ito K channls
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transient outward K channels - force membrane potential back to RP
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Phase 2
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E and M systole - slow Ca's open in response to phase 1 depol to keep MP depolartized (K's open too!) - Ca influx causes SR release and contraction - Ito Ks inactivate but DRK's activate to keep the K conductance high
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Phase 3
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End of E systole - Repol - all DRKs open up, Ca channels inactivatied
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