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33 Cards in this Set
- Front
- Back
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which particles are for tx
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alpha emitters
beta minus emitters |
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which particles are for dx
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beta plus
gamma |
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what is a radiopharmaceutical
example? |
a pharmaceutical lperparation containing a radionuclide
F18, Tc99m, |
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how is energy of radiation measured
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Gy (absorbed dose)
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how is type of radiation measured
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equivalent dose
measured in Sv |
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what does equivalent dose refer to
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the type of radiation
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what does effective dose refer to
mesaured in |
what organ is being targetted
Sv |
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1 Gy =
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100 Rad
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1 rad =
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0.01 Gy
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1 Sv =
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100 rem
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10 rem =
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0.1 Sv
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1 Ci =
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37,000 MBq
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1 mCi =
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37 MBq
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which radiation measurements are SI units
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Sv, Gy
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what does Gy measure
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energy of radiation (how much dose is absorbed)
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what dose equivalent dose measure
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takes into account biological damage when interaction is with a particular tissue, compared to damage from photons
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what does rem stand for
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Roenten equivalent man
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how is delivered dose calculated
units |
amt of activity in source organ x time
Bq-s |
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how to calculate effective t 1/2
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Tp x Tb/Tp+Tb
(Tp = physical t 1/2, Tb = biological t 1/2). |
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what is used to test radiochemical purity
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thin layer chromatography
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what does TLC look for
how does it work |
free tech
tech moves and Tc-SC/MAA, etc stays in place |
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what is radionuclide purity
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% ratio between activity of radionuclide and total acctivity in prep
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example of radionuclide purity
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Mo breakthrough (Tc comes from a Mo generator)
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how is radionuclide purity tested
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spectromotry wiht NaI or high purity germanium detectors
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what is the max level of radionuclide impurity allowed for mo
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no more than 0.15 micoCi of Mo99 is allowed per mCi of Tc99m
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define chemical purity
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% quantity radionuclide in desired form vs other chemical species
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how does chemical purity differ from radiochemical purity
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unlike radiochemical purity, it also looks at non-radioactive substances
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example of chemical purity test
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how much Al is in Tc99m 2/2 elution
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which is chemical impurity a problem
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can interfere with the labeling processs
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minimum chemical purity of Tc99m
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should be greater than 99%
no greater than 10ug/1mL alumina |
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how are radionuclides checked for pyrogenic materials
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inject material into rabbits or
limulus amebocyte lysate test --> opaque gel if pyrogens are detected |
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how is chemical purity tested for
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qualitative colorimetric analysis (put radionuclide on a special paper. if it turns pink then there is too much Al)
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define LD 50/60
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doseage producing 50% mortality in 60 days in 2 animal species
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