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65 Cards in this Set

  • Front
  • Back
From whence do things things radioactive come from?
Accelerators
Fission reactors/Power Reactors=outside the country, Canada, Sweden
Naturally Occurring
Radionuclide Generators
Particle Accelerators

Linear Accelerator =
Moves particles in a straight path.
Radiation therapy, high energy X-Ray/electrons
Cyclotron
Moves particles in a circular path.
Linear accelerator are usually large.
Cyclotron can be kept in a relatively small room.
Cyclotrons can produce
carrier free material; all useful product.
Particles in an accelerator
gain energy, can reach one billion volts.
Particles must be charged to be accelerated. Use of attractive and repulsive forces
are used in an accelerator to speed up the particle.
Particles accelerated can be protons, or
2H,3H,4H.
Energy gained must be sufficient to overcome repulsive attraction
of the positive particle and the positive nucleus. There is a threshold energy for these reactions.
Accelerating a positive charge particle
Enough speed will overcome repulsive forces and create nuclear reactions
Isotopes produced by cyclotron used in NM
TI-201
I-123
Ga- 67
PET isotopes
N-13
0-15 = short half life, more for research
F-18
Direct reaction
Study
Indirect Reaction Study
Conseil europeen pour la recherche Nucleaire
CERN
The largest particle physics laboratory in the world, located at Geneva.
Very large accelerators are used to smash particles into each other
The fragments of the collisions are detected
and studied
Experiments have found new short lived fundamental particles. One of the first to be discovered was a third charge particle like the electron and the muon. This new particle called the
tau, lives for only one third of a millionth of a millionth of a second (0.3 x 10^-12s)
Fissions Reactions
- Largest source
All the radionuclides used in nuclear medicine are man made, They are either created in a reactor, or made in a particle accelerator by bombarding a target with charged particles.
Study the diagram of
the nuclear reactor
Spontaneous fission is an extremely unlikely event.
Naturally occurring isotopes which meet this condition are very stable against spontaneous fission. Fission mist be initiated by neutrons.
235U + n ---->
236U fission fragments + neutrons + energy
- binding energy
Energy released from one atom of U-235 fissioning is about 200 MeV
1.125 g fissioned/MW-d
Fission fragments range from Z = 30- 64.
The two fragments are usually split in weight in a 60:40 ratio.
Criticality (mass)
Neutrons produced by a fission reaction lead to more fission reactions.
Fission reactions are important for 2 reasons in NM

1.
Fission fragments are usually radioactive, if they are separable, they can be used as medical tracers.
I-131 and Mo-99 are fission fragments
2.
Neutrons are produced in reactors, these neutrons can be used to produce radioactive material through "neutron activation"
- Neutrons enter an atom very easily
Fission of U235 usually splits into the atom of about
60/40 ratio
235 x 0.6 = 94

235 x 0.6 = 141
Nuclear Reactors

a. fuel elements
typically U235 or a combination of U235 & U238
Natural Uranium is only 0.7% U-235
It must be enriched 3-5 % U-235 for use as fuel in a light water reactor
- Weapons grade uranium is 85% U-235
Nuclear Reactors
b. moderators
low Z material, used to slow neutrons, graphite and water
c. control rods
control fission reaction rate, composed of material which absorbs neutrons, like boron & cadmium = grab onto neutrons a lot!, neutron affinity
Neutron Activation
Involves the capture of a neutron by a stable nucleus transforming it into a radioactive substance.
(n.y) reaction
32P + n --> 33P + y

This is a neutron = gamma reaction
Product is always an isotope of the parent, Atomic mass increases by
1
The parent is never completely activated resulting
in the product have a carrier, which is 32 P, never a carrier free.
Transmutation
the process by which one element is converted into another
(n,p) reaction
32S + n ----> 32 + p
Target and product are
isobars!
They have different elements so they can be separated chemically resulting in a
carrier free product
There are no radioisotopes which are neuron emitters for practical purposes.
no natural element
Radioactivity from these series contributes to a environmental background radiation.
Naturally occurring radioactivity does not come only from these series. Other isotopes also naturally occur, the most important for these for human exposure is Potassium - 40
Carbon -14 is also an important isotope because it is incorporated in plants. The isotope is continually produced in the
atmosphere from Nitrogen-14.
Radionuclide Generators
box with radioactive in it = it decays into something useful that we need/use
Special Cases for Radioactivity
Isotopes which decay to other radioisotopes are known as serial transformations.
Serial transformations pose an interesting situation which they are in a
sealed system
Three situations will be considered:
1. Secular Equilibrium
2. Transient Equilibrium
3. A No Equilibrium situation.
Secular Equilibrium
This occurs when the half life of the parent is much greater than the half life of the daughter
Secular Equilibrium 2
Tp>> td
Secular Equilibrium 3
In this situation, the parent decays so slowly it is as if the activity of the parent is constant.
As the parent slowly decays, the activity of the daughter increases.
It requires about 4 daughter half life's for the activity of the parent and the daughter to reach equilibrium.
Equilibrium in this case is when the activity of the parent and the daughter are about constant.

25 days v 75 seconds.
Three situations will be considered:
1. Secular Equilibrium
2. Transient Equilibrium
3. A No Equilibrium situation.
Secular Equilibrium
This occurs when the half life of the parent is much greater than the half life of the daughter
Secular Equilibrium 2
Tp>> td
Secular Equilibrium 3
In this situation, the parent decays so slowly it is as if the activity of the parent is constant.
As the parent slowly decays, the activity of the daughter increases.
It requires about 4 daughter half life's for the activity of the parent and the daughter to reach equilibrium.
Equilibrium in this case is when the activity of the parent and the daughter are about constant.

25 days v 75 seconds.
The Cardio-Gen 82 is commercially available for
Rubidium-82
- PET + nuclear cardiology & Positron emitter
Sr-82 with a half life of 25 days, decays to Rb-82 with a half life of
75 seconds.
- generator hooked up to patient
What can we expect of these isotopes in a closed system?
Answer
Transient Equilibrium
This occurs when the half life of the parent is longer then the half life of the daughter, but not extremely longer.
This occurs when the half life of the parent is longer then the half life of the daughter
but not extremely longer.
Tp > Td
- In this case, as the parent isotope decays, the daughter builds up from zero until
it surpasses the parent activity.
When the daughter activity reaches its maximum value, the decay of the daughter
follows the decay of the parent.
When this state of parallel decay is reached, the parent and daughter activates decreases
but the ratio of the parent and daughter activities remains constant.
6 days vs 6 hours
With transient equilibrium the equilibrium activity of the daughter changes with time because
the parent activity is changing. After the condition of equilibrium is reached, the daughter appears to decay with the half life of the parent.
No Equilibrium
This occurs when the half life of the parent is shorter than the half life of the daughter.