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65 Cards in this Set
- Front
- Back
From whence do things things radioactive come from?
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Accelerators
Fission reactors/Power Reactors=outside the country, Canada, Sweden Naturally Occurring Radionuclide Generators |
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Particle Accelerators
Linear Accelerator = |
Moves particles in a straight path.
Radiation therapy, high energy X-Ray/electrons |
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Cyclotron
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Moves particles in a circular path.
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Linear accelerator are usually large.
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Cyclotron can be kept in a relatively small room.
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Cyclotrons can produce
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carrier free material; all useful product.
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Particles in an accelerator
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gain energy, can reach one billion volts.
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Particles must be charged to be accelerated. Use of attractive and repulsive forces
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are used in an accelerator to speed up the particle.
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Particles accelerated can be protons, or
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2H,3H,4H.
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Energy gained must be sufficient to overcome repulsive attraction
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of the positive particle and the positive nucleus. There is a threshold energy for these reactions.
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Accelerating a positive charge particle
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Enough speed will overcome repulsive forces and create nuclear reactions
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Isotopes produced by cyclotron used in NM
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TI-201
I-123 Ga- 67 |
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PET isotopes
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N-13
0-15 = short half life, more for research F-18 |
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Direct reaction
Study |
Indirect Reaction Study
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Conseil europeen pour la recherche Nucleaire
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CERN
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The largest particle physics laboratory in the world, located at Geneva.
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Very large accelerators are used to smash particles into each other
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The fragments of the collisions are detected
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and studied
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Experiments have found new short lived fundamental particles. One of the first to be discovered was a third charge particle like the electron and the muon. This new particle called the
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tau, lives for only one third of a millionth of a millionth of a second (0.3 x 10^-12s)
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Fissions Reactions
- Largest source |
All the radionuclides used in nuclear medicine are man made, They are either created in a reactor, or made in a particle accelerator by bombarding a target with charged particles.
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Study the diagram of
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the nuclear reactor
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Spontaneous fission is an extremely unlikely event.
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Naturally occurring isotopes which meet this condition are very stable against spontaneous fission. Fission mist be initiated by neutrons.
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235U + n ---->
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236U fission fragments + neutrons + energy
- binding energy |
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Energy released from one atom of U-235 fissioning is about 200 MeV
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1.125 g fissioned/MW-d
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Fission fragments range from Z = 30- 64.
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The two fragments are usually split in weight in a 60:40 ratio.
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Criticality (mass)
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Neutrons produced by a fission reaction lead to more fission reactions.
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Fission reactions are important for 2 reasons in NM
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Fission fragments are usually radioactive, if they are separable, they can be used as medical tracers.
I-131 and Mo-99 are fission fragments |
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2.
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Neutrons are produced in reactors, these neutrons can be used to produce radioactive material through "neutron activation"
- Neutrons enter an atom very easily |
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Fission of U235 usually splits into the atom of about
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60/40 ratio
235 x 0.6 = 94 235 x 0.6 = 141 |
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Nuclear Reactors
a. fuel elements |
typically U235 or a combination of U235 & U238
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Natural Uranium is only 0.7% U-235
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It must be enriched 3-5 % U-235 for use as fuel in a light water reactor
- Weapons grade uranium is 85% U-235 |
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Nuclear Reactors
b. moderators |
low Z material, used to slow neutrons, graphite and water
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c. control rods
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control fission reaction rate, composed of material which absorbs neutrons, like boron & cadmium = grab onto neutrons a lot!, neutron affinity
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Neutron Activation
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Involves the capture of a neutron by a stable nucleus transforming it into a radioactive substance.
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(n.y) reaction
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32P + n --> 33P + y
This is a neutron = gamma reaction |
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Product is always an isotope of the parent, Atomic mass increases by
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1
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The parent is never completely activated resulting
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in the product have a carrier, which is 32 P, never a carrier free.
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Transmutation
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the process by which one element is converted into another
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(n,p) reaction
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32S + n ----> 32 + p
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Target and product are
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isobars!
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They have different elements so they can be separated chemically resulting in a
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carrier free product
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There are no radioisotopes which are neuron emitters for practical purposes.
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no natural element
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Radioactivity from these series contributes to a environmental background radiation.
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Naturally occurring radioactivity does not come only from these series. Other isotopes also naturally occur, the most important for these for human exposure is Potassium - 40
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Carbon -14 is also an important isotope because it is incorporated in plants. The isotope is continually produced in the
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atmosphere from Nitrogen-14.
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Radionuclide Generators
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box with radioactive in it = it decays into something useful that we need/use
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Special Cases for Radioactivity
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Isotopes which decay to other radioisotopes are known as serial transformations.
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Serial transformations pose an interesting situation which they are in a
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sealed system
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Three situations will be considered:
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1. Secular Equilibrium
2. Transient Equilibrium 3. A No Equilibrium situation. |
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Secular Equilibrium
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This occurs when the half life of the parent is much greater than the half life of the daughter
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Secular Equilibrium 2
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Tp>> td
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Secular Equilibrium 3
In this situation, the parent decays so slowly it is as if the activity of the parent is constant. |
As the parent slowly decays, the activity of the daughter increases.
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It requires about 4 daughter half life's for the activity of the parent and the daughter to reach equilibrium.
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Equilibrium in this case is when the activity of the parent and the daughter are about constant.
25 days v 75 seconds. |
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Three situations will be considered:
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1. Secular Equilibrium
2. Transient Equilibrium 3. A No Equilibrium situation. |
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Secular Equilibrium
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This occurs when the half life of the parent is much greater than the half life of the daughter
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Secular Equilibrium 2
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Tp>> td
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Secular Equilibrium 3
In this situation, the parent decays so slowly it is as if the activity of the parent is constant. |
As the parent slowly decays, the activity of the daughter increases.
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It requires about 4 daughter half life's for the activity of the parent and the daughter to reach equilibrium.
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Equilibrium in this case is when the activity of the parent and the daughter are about constant.
25 days v 75 seconds. |
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The Cardio-Gen 82 is commercially available for
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Rubidium-82
- PET + nuclear cardiology & Positron emitter |
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Sr-82 with a half life of 25 days, decays to Rb-82 with a half life of
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75 seconds.
- generator hooked up to patient |
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What can we expect of these isotopes in a closed system?
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Answer
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Transient Equilibrium
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This occurs when the half life of the parent is longer then the half life of the daughter, but not extremely longer.
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This occurs when the half life of the parent is longer then the half life of the daughter
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but not extremely longer.
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Tp > Td
- In this case, as the parent isotope decays, the daughter builds up from zero until |
it surpasses the parent activity.
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When the daughter activity reaches its maximum value, the decay of the daughter
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follows the decay of the parent.
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When this state of parallel decay is reached, the parent and daughter activates decreases
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but the ratio of the parent and daughter activities remains constant.
6 days vs 6 hours |
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With transient equilibrium the equilibrium activity of the daughter changes with time because
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the parent activity is changing. After the condition of equilibrium is reached, the daughter appears to decay with the half life of the parent.
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No Equilibrium
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This occurs when the half life of the parent is shorter than the half life of the daughter.
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