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17 Cards in this Set

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How does AcH affect passive diffusion?
Increases it - dilates when it hits metabotropic smooth muscle receptors via Ca2+ influx which activates NOS/cGMP to dilate.
How does vascular fibrosis affect passive diffusion?
Decreases it - increases the distance across the membrane.
How does pegylation affect passive diffusion?
Increases it - makes things lipophilic
How woudl the resting membrane potential change by increasing extracellular sodium?
It would depolarize
How woudl the resting membrane potential change by increasing intracellular potassium?
It would hyperpolarize
How woudl the resting membrane potential change by increasing extracellular potassium?
Up to 20 mM hyperpolarize

Above 20 mM depolarize
How woudl the resting membrane potential change by increasing potassium permeability?
Hyperpolarize
How does Oubain work?
-Inhibits Na/K ATPase
-Small membrane depolarization
-Less Na/Ca exchange
-Calcium reduces Ethreshold
-More Ca in SR
-More excitable and increased contractility
3 Ways to increase the force of a skeletal muscles contraction:
1. Quantel summation
2. Temporal summation
3. Length tension diagram
Resting length:
The length where force in a muscle is maximal - optimal length
Equilibrium length:
The length where force is minimum
How does the force-velocity curve change as a muscle's length increases toward resting length?
As force increases velocity decreases, so as you go from Le to Lo velocity decreases until you can't lift the darn thing off the floor and force becomes isometric.
How will liver failure affect bulk flow at the capillaries?
It will increase NFP greatly due to loss of plasma oncotic pressure
What does Botulinum toxin do?
Inhibits vesicle release of ACh - inhibits muscle contraction b/c no ACh to bind nicotinic receptors.
What does Curare do?
Blocks binding of ACH nicotinic receptors - inhibits NMJ transmission
What does Atropine do?
-Blocks Muscarinic cholinergic receptors on smooth muscle
-prevents smooth muscle dilation
-increases heart rate
What stimulates the release of ACh to cause dilation by its muscarinic receptors?
PNS - parasymp