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17 Cards in this Set
- Front
- Back
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How does AcH affect passive diffusion?
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Increases it - dilates when it hits metabotropic smooth muscle receptors via Ca2+ influx which activates NOS/cGMP to dilate.
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How does vascular fibrosis affect passive diffusion?
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Decreases it - increases the distance across the membrane.
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How does pegylation affect passive diffusion?
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Increases it - makes things lipophilic
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How woudl the resting membrane potential change by increasing extracellular sodium?
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It would depolarize
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How woudl the resting membrane potential change by increasing intracellular potassium?
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It would hyperpolarize
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How woudl the resting membrane potential change by increasing extracellular potassium?
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Up to 20 mM hyperpolarize
Above 20 mM depolarize |
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How woudl the resting membrane potential change by increasing potassium permeability?
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Hyperpolarize
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How does Oubain work?
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-Inhibits Na/K ATPase
-Small membrane depolarization -Less Na/Ca exchange -Calcium reduces Ethreshold -More Ca in SR -More excitable and increased contractility |
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3 Ways to increase the force of a skeletal muscles contraction:
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1. Quantel summation
2. Temporal summation 3. Length tension diagram |
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Resting length:
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The length where force in a muscle is maximal - optimal length
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Equilibrium length:
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The length where force is minimum
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How does the force-velocity curve change as a muscle's length increases toward resting length?
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As force increases velocity decreases, so as you go from Le to Lo velocity decreases until you can't lift the darn thing off the floor and force becomes isometric.
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How will liver failure affect bulk flow at the capillaries?
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It will increase NFP greatly due to loss of plasma oncotic pressure
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What does Botulinum toxin do?
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Inhibits vesicle release of ACh - inhibits muscle contraction b/c no ACh to bind nicotinic receptors.
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What does Curare do?
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Blocks binding of ACH nicotinic receptors - inhibits NMJ transmission
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What does Atropine do?
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-Blocks Muscarinic cholinergic receptors on smooth muscle
-prevents smooth muscle dilation -increases heart rate |
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What stimulates the release of ACh to cause dilation by its muscarinic receptors?
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PNS - parasymp
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