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43 Cards in this Set

  • Front
  • Back
paralysis of swallowing, nerve damage
CN 5, 9, or 10
poliomyelitis or encephalitis damage swallowing via…
damage to swallow center in brain stem
what can cause swallowing impairment due to muscles
myasthenia gravis or batulism, muscular dystrophy
What occurs when swallowing impaired
1) swallowing can't occur 2) failure of glottis to close (food goes into lungs) 3) failure of soft palate and uvula (food goes to nose)
achalasia
lower esphageal sphincter fails to relax during swallowing; damage to myenteric plexus
what is much gastritis caused by
chronic bacterial infection of gastric mucosa
what are 2 most common substances that damage tight epithelial jxns
alcohol, aspirin
why doesn't the stomach absorb much
1) tight jxns 2) lines with highly resistant mucous cells
what does gastic atropy and stomch secretion depletion lead to
achlorhydria and occasionally pernicious anemia
diagnosis of achlorhydria
pH of stomach secretions fail to decrease below 6.5 after maximal stimulation
intrinsic factor is made by and helps absorption of…
parietal cells in stomch, vit B12
commonpeptic ulcer locations
around pyloric sphincter
cause of peptic ulcer formation
1) excess secretion of acid and pepsin by stomach 2) diminished ability of gastroduodenal mucosal barrier to protect
large amount of bicarb provided in…
1) secretions of large brunner's glands 2) bile from liver
two methods of mediating acid entering duodenum
1) inhibit gastric secretion 2) secretin stimulates pancreatic juice release
factors predisposing to ulcers
1) smoking 2) alcohol 3) aspirin
ranitidine
acid-suppressant drug; anti-histiminic, reduces acid secretion by 70-80%
when does lack of pancreatic secretion occur
1) pancreatitis 2) duct blocked by gallstone 3) head of pancreas removed due to malignancy
what percent of fat is not digested if pancretic secretion doen't occur
60%, along with 1/3 to 1/2 proteins and carbs
most common cause of pancreatitis
drinking excess alcohol, then gallstone blocking papilla of vater
sprue
malabsorption by intestinal mucosa
nontropical sprue
toxic effects of gluten present in some types of grain; also called idiopathic sprue , celiac disease in children, and gluten enteropathy
what happens in nontropical sprue
direct destructive effect on intestinal enterocytes
tropical sprue
thought to be caused by unidentified infectious agents
how can you tell sprue is malabsorption rather than inability to digest
fat in stools is in the form of salts of fatty acids, not undigested fat
steatorrhea
excess fat in stools
severe sprue can cause…
1) nutritional deficiency 2) osteomalacia 3) inadequate blood coagulation 4) macrocytic anemia (pernicious anemia)
spasms in colon
constipation for several days followed by a day or so of diarrhea due to colonic secretions
megacolon aka hirschsprung's disease
lack of or deficiency of ganglion cells in myenteric plexus of sigmoid colon
pstchogenic diarrhea
excessive stimulation of parasympathetic nervous system which excites motility and excess mucous secretion
healing ulcers in ulcerative colitis
iliostomy to allow small intestine contents to drain exterior while heals
spinal cord injury btwn conus medullaris and brain
voluntary portion of defecation blocked, but basic cord reflex still intact
where so sensory signals that initiate vomiting originate
pharynx, esophagus, stomach, upper portions of small intestine; travel via vagal and sympathtic afferent nerve fibers to multiple nuclei in brain stem
motor impulses of vomiting
CN 5, 7, 9, 10, and 12 to upper GI, vagus and sympathetic to lower GI, and spinal nerves to diaphram and abdominal muscles
antiperistalsis
up GI tract 2-3 cm/sec; eberything in stoch in 3-5 minutes; distention of duodenum/stomach causes vomiting
vomiting
1) deep breath 2) raising of hyoid bone and larynx to pull upper esophageal sphincter open 3) closing glottis 4) lifting soft palate to close nares 5) contraction of diaphragm and abdominal muscles
chemoreceptor trigger zone
motion sickness, some drugs; located bilaterally on floor of 4th ventricle
nausea causes
1) irritative impulses from GI tract 2) impulses from brain due to motion sickness 3) impulses from cerebral cortex
common causes of GI obstruction
1) cancer 2) fibrotic constriction from ulceration or peritoneal adhesions 3) spasm of segment of gut 4) paralysis of segement of gut
obstruction at pylorus
depresses body nutrition, loss of H+ ions (body alkalosis)
obstruction beyond stomach
loose large amount of water, electrolytes; no acid-base imbalance
obstruction near distal end of large intestine
feces accumulate, no vomiting at first, then severe vomiting
gases formed in large intestine vs expelled gas
7-10 liter; 0.6 L expelled, remaining is absorbed into blood and mucosa and expelled through lungs