Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
Structure of glycerophospholipids
|
Glycerol w/ fatty acid at C1 and C2
exchange group at phosphate |
|
phosphatidic acid
|
beginning structure. Add to phosphate -OH to change into other glycerophospholipids.
|
|
Licithin
|
Phosphotydalcholine
need to produce surfactant. w/ dificiency get dermatitus can get arachadonic acid from |
|
phosphotidylinosital
|
used in signal transduction.
broken down by Phospholipase C to form IP3 and DAG. synthesis inhibited by lithium. contains arachadonic acid. |
|
production of phosphotidylinositol, cardiolipin, phosphatidylglycerol
|
CTP-diacylglycerol is formed and binds glycerophospholipid.
|
|
production of phsphtidyl- choline, ethanolamine, serine
|
CTP binds head group, then combines with diacylglycerol and phospholipid
|
|
cytodine nucleotide
|
CTP is used to activate headgroups and DAG. CMP is released from reaction
|
|
Colleen Lakker
|
respiratory distress syndrome
6 week premature infant not enough sufactant(surface tension) |
|
Red Scaly dermititis
|
happens with choline deficiency
need 550 mg/day men 425 women happens with total parenteral nutrition |
|
Total parenteral nutrition
|
leads to choline dificiency
red scaly dermititus |
|
Phospholipase A1
|
present in many tissues
removes FA from C1 |
|
Phospholipase A2
|
present in many mammalian tissues and pancreatic tissues
relases archodonic acid from phosphotidylinositol is a proenzyme, and activated by trypsin inhibited by glucocorticoids |
|
cortisol/glucocorticoids
|
inhibits Phosphoipase A2.
stops release of arachodonic acid |
|
Phospholipase C
|
found in liver lysosomes and alpha toxin of clostridia and other bacilli
activated by the PIP2 system plays a role in signal tranduction produces IP3 and DAG from PIP2 cleaves the phosphate group |
|
phosphotidylinositol/second messenger
|
PIP2 is cleaved by phospholipase C to produce IP3 and DAG.
IP3 binds with ER to cause release of Ca Ca activates protein kinase C and DAG enhances activity causes phosphorylation cascade |
|
Litium
|
inhibits the production of phosphotidylinositole
inhibits the production of inisitol myo |
|
Phosphotidylinositole degradation and recycling
|
inhibited by lithium
DAG to phosphotidic acid then activated with CTP IP3 is converted to inositole myo |