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104 Cards in this Set
- Front
- Back
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Carbachol
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activates muscarinic and cholinergic receptors, long acting
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Bethanachol
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activates muscarinic receptors, long acting,
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Acetylcholine
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short half life, used intraocularly during eye surgery
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Methacholine
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longer acting, aerosol for bronchial asthma
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Sildenafil
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Take for a good time, fellas.
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Pilocarpine
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treat xerostomia (dry mouth), treats post-op abdominal distension, fights urinary retention
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Muscarine
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from a plant
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Physostigmine
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orally effective, active in CNS, longer acting, glaucoma
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Neostigmine
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quaternary N, can't enter CNS, cause mm. contraction gut/bladder. curare-like paralysis antidote
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Pyridostigmine
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longer acting than neostigmine, treatment of myasthenia gravis
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Edrophonium
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short duration (10 min t1/2) excreted by kidney, myasthenia gravis. curare-like paralysis antidote, nodal tachycardia
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Carbaryl
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kills head lice
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Donepezil
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long acting, lipid soluable, delays cognitive decline w/Alzheimer's
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Galantamine
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long acting, lipid soluable, delays cognitive decline w/Alzheimer's
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Rivastigmine
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long acting, lipid soluable, delays cognitive decline w/Alzheimer's
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Echothiophate
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treats glaucoma, can cause muscle spasm
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Malathion
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insecticide
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Chlorpyrifos
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insecticide, neurotoxin
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VX
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nerve gas
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Sarin
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nerve gas
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Atropine
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acts on muscarinic receptors, decreases saliva
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Scopolamine
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Reduces motion sickness, penetrates skin, preanesthesia med.
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Benztropine
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Parkinson's disease, antipsychotic induced dyskinesias
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Ipratropium bromide
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treats chronic bronchitis & bronchospasm of COPD, less side eff.
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Cyclopentolate
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causes mydriasis
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Homatropine
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paralyzes accomodation, causes mydriasis
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Oxybutnin
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overactive bladder
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Tolterodine
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overactive bladder
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Tiotropium
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treats chronic bronchitis & bronchospasm of COPD, less side eff.
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Tropicamide
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fix pupil after trauma, causes mydriasis
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Trimethaphan
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blcoks ACh @ ganglia, decreases blood pressure
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Curare
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blocks ACh @ sk. mm., mm. paralysis
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Nicotine
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low doses agonist, high doses antagonist
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Hemicholinium
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stops choline from getting in
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Botulinum Toxin
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attacks SNARE proteins
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Phenylephrine
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acts only at α1 receptors, nasal decongestant, dilate pupil
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Isoproterenol
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acts only at β1 and β2 receptors
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Cocaine
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blocks NE uptake/enhances NE
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Amphetamine
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NE @ NET released instead of taken up
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Phentolamine
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blocks α1 receptors
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Propranolol
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blocks β1 receptors and β2
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Guanethidine
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blocks NE release from synapse
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α Methyltyrosine
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blocks conversion of tyrosine into dopamine
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Reserpine
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destroys NE vessicles so it can't be released
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α Methyl DOPA
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treats HT in pregnant women
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Norephinephrine
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direct acting α1, α2, β1agonists
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Epinephrine
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direct acting α1, α2, β1, β2 agonists
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Phenylephrine
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direct acting α1 agonists, nasal decongestant, dilate pupil
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Methyldopa
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Clonidine
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direct acting α2 agonists
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Brimonidine
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Epinephrine
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direct acting α1, α2, β1, β2 agonists
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Isoproterenol
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direct acting β1, β2 agonists
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Terbutaline
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selective β2 agonists, treat acute asthma
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Albuterol
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selective β2 agonists, treat acute asthma
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Dobutamine
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IV admin, selective β1 agonists, short acting. no vomitting, no release NE, no increase renal blood. used for shock
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Ritodrine
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selective β2 agonists, prevents premature labor. caution w/diabetic patients, cause hyperglycemia
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Salmeterol
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selective β2 agonists, treat chronic asthma
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Dopamine
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IV admin, selective β1 agonists, short acting. vomitting, increase renal blood flow, used for shock
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Tyramine
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Amphetamine
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periphery-release NE, CNS-release dopamine. can cross BBB, excrete unchanged in urine
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Ephedrine
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indirect release NE, direct β1. CNS stimulation (anorexigenic). less potent than Epi, but longer acting, can cross BBB
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Pseudoephedrine
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lack direct β2 stimulation, less CNS stimulation
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MDMA
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"ecstasy" increase alterness and motor activity
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Cocaine
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short acting, peripheral, local anesthetic, CNS stimulant
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Methylphenidate
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Dopamine
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Haloperidol
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blocks dopaminergic receptors, antipsychotic
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Phenelzine
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MAO inhibitor, used in depression
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Entacapone
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COMT inhibitor, used in Parkinsons
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Phentolamine
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Reversible, causes postural hypotension
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Prazosin
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produces least tachycardia, selective α1 antagonist
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Phenoxybenzamine
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Irreversible, causes postural hypotension, for pheochromocytoma
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Tamsulosin
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selective α1 antagonist, less postural hypotension
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Terazosin
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longer acting than prazosin, treats BPH
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Doxazosin
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longer acting than prazosin, treats BPH
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Side Effects
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tachycardia, postural hypotension, inhibition of ejaculation, increased blood volume, sodium retention, nasal stuffiness
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Propranolol
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nonselective competetive antagonist at β1 and β2
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Timolol
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blocks β1 and β2, oral and topical for glaucoma
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Nadolol
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long acting (22 hr t1/2) compliance, blocks β1 and β2
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Metoprolol
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selective β1 antagonist
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Atenolol
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selective β1 antagonist
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Esmolol
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t1/2 8 min, selective β1 antagonist
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Labetalol
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5 hr t1/2, blocks β1 and β2,and α1
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Pindolol
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4 hr t1/2, blocks β1 and β2, slight β1 agonist, hypertensive crisis
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Carvedilol
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8 hr t1/2, blocks β1 and β2, slight α1 antagonist
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Reserpine
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long lasting, calms schizophrenics, treat mild HT
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Methyldopa
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moderate to severe HT in pregnant women
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Clonidine
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centrallu active, treats opiate withdrawl, migraine, moderate HT
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α Methyltyrosine
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inoperable pheochromocytoma
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Carbidopa
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inhibits AD in periphery but not CNS(can't cross BB), reduces side effects of dopamine
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Entacapone
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reduces "wearing off" symptoms of Parkinsons
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Phenelzine
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MAO inhibitor, treats severe mental depression
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Yohimbine
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Carbachol
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activates muscarinic and cholinergic receptors
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Echiothiophate
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AChE inhibitor, cause vision impairement, cyclospasm
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Atropine
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acts on muscarinic receptors, decreases saliva
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Pilocarpine
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treats primary angle-closure glaucoma, direct muscarinic aonist
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Physostigmine
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AChE inhibitor, cause vision impairement, cyclospasm
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Tropicamide
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muscarinic antagonist, causes mydriasis and cycloplegia
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Apraclonididne
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α2 cholinergic antagonist, reduces intraocular pressure
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Brimonidine
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reduces aqueous humor production, α2 agonist
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Dipivefrin
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reduces aqueous humor production, prodrug for epinephrine
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Timolol
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reduces aqueous humor production
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