Phm 350 Exam 1

Front 1

To reduce the tachycardia characteristic of paroxysmal atrial tachycardia, which of the following drugs would bring your heart rate back to "normal" through its actions outside the heart?

Back 1

B. Methoxamine

Front 2

You have a dry mouth, dilated pupils, and a high heart rate. From these symptoms you conclude that u have received an overdose of:

Back 2

A. Atropine

Front 3

Albuterol:

Back 3

B. Activates non innervated Beta2 receptors to dilate blood vessels of skeletal muscle

Front 4

Atracurium

Back 4

A. Is used as a muscle relaxant in surgical procedures

Front 5

The therapeutic threshold concentration (aka minimal effective conc.) of a drug:

Back 5

D. Is the minimum plasma concentration of the drug which is required to induce the desired therapeutic response

Front 6

An expected side effect when using systemically administered Bethanechol to treat atony of the urinary bladder after childbirth:

Back 6

E. A and C

A. Decreased heart rate (bradycardia)

C. Decreased blood pressure resulting from vasodilation of some blood vessels

Front 7

A pharmacological antagonist at a particular type of receptor

Back 7

E. A and C

A. will bind but not activate those receptors

C. Will have physiological or clinical efficacy (based on its activity at those receptors

Front 8

Norepinephrine

Back 8

D. Is the neurotransmitter at most postganglionic neuron - effector cell syn apses in the sympathetic nervous system

Front 9

An appropriate drug to reverse the effects of atropine overdose:

Back 9

A. Physostigmine

Front 10

All of the following routes of administration are classified as parenteral except:

Back 10

B. Oral

Front 11

You are salivating excessively and your muscle strength seems less than normal. From these symptoms, you conclude that you have received an overdose of:

Back 11

A. Neostigmine

Front 12

Uses of anticholinesterases in therapy include administration by appropriate routes to:

Back 12

C. Restore urinary bladder function in individuals with urinary bladder atony

Front 13

Figure of response vs dose

Back 13

E. A and C

Front 14

Glycopyrrolate is administered with a general anesthetic in many instances because glycopyrrolate will:

Back 14

E. A and C

A. Reverse general anesthesia induced bradycardia and block of conduction through AV node

C. Reduce bronchoconstriction

Front 15

The idea of spare receptors comes from evidence that:

Back 15

D. For full agonists, EC50 is less than KD50

Front 16

Activation of the sympathetic nervous system

Back 16

A. increases heart rate

Front 17

Figure of response vs dose with antagonists

Back 17

B. For the receptor activated by the full agonsist, antagonist t has a higher affinity than ant S

Front 18

Phenylephrine will increase pressure by

Back 18

A. Activation of a1 adrenoreceptors on blood vessels of the skin and mesentary

Front 19

A drug which might be expected to reduce blood pressure through effects on receptor on blood vessels but which has no direct effect on cardiac output

Back 19

B. Prazosin

Front 20

Edrophonium is preferred over other drugs to differentially diagnose cholinergic cris and myasthenia gravis because:

Back 20

D. Edrophonium is a short acting cholinesterase inhibitor

Front 21

A drug which mimics acetylcholine at cholinergic receptors in autonomic ganglia but is not a choline ester:

Back 21

E. Nicotine

Front 22

Drug A is administered repeatedly with a constant interval between consecutive doses and with a constant dose. The mean plasma concentration of drug A is measured. This concentration:

Back 22

B. 1 and 3 are correct

Front 23

A drug which has high affinity for a1 adrenoreceptors and very low affinity for other adrenoreceptors and which is an agonist at a1 adrenoreceptors:

Back 23

A will be useful as a nasal decongestant

Front 24

Atenolol and propanolol can both be used to treat hypertension. Atenolol may be preferred over propranolol for this purpose because, as a side effect, propranolol:

Back 24

D. Can cause coronary artery constriction

Front 25

A drug which when adminstered intravenously does not enter the Central nervous system rapidly, increases gastrointestinal motility but does not affect skeletal muscle contraction

Back 25

A. Bethanechol

Front 26

A drug that activates receptors and initiates a series of cellular reactions that result in a less than maximal response by the cell/tissue/organ, even when it binds 100% of those receptors is:

Back 26

A. a partial agonist

Front 27

Trimethaphan

Back 27

C. is an antagonist at nicotinic receptors in autonomic ganglia

Front 28

A drug which is a substrate for cholinesterases, increases salivary secretion, and will increase binding of acetylcholone released from motor neurons to cholinergic receptors on skeletal muscle

Back 28

D. physostigmine

Front 29

Dobutamine:

Back 29

D. Mimics the effects of isoproterenol to alter heart rate and contractility of heart muscle

Front 30

Epinephrine:

Back 30

C. Causes hypoglycemia by inducing insulin secretion from the pancreas

Front 31

Clondine

Back 31

B. Activates adrenoreceptors on axon terminals of neuroepinephrine-secreting neurons

Front 32

A drug which reduces contraction of the uterus in pregnant women:

Back 32

B. Terbutaline

Front 33

Dopamine:

Back 33

E. A and C

A, Activates B1 Adrenoreceptors in the heart

C. INduces vasodilation through activation of vascular dopamine receptors

Front 34

A drug which induces miosis when applied to the eye but has a different mechanism of action than pilocarpine

Back 34

D. Physostigmine

Front 35

Epinephrine decreases diastolic blood pressure by

Back 35

A. Activation of B2 adrenoreceptors on the blood vessels of skeletal muscle

Front 36

The liver enzyme Z metabolizes Drug A. If Drug A is administered repeatedly, then the amount of Enzyme Z in the liver is increases. Consequently...

Back 36

A. The halflife of the drug A will be decreased

Front 37

The direct actions of atropine in the heart:

Back 37

A. Include increased heart rate

Front 38

Pilocarpine is administered topically to the eye to treat glaucoma because systematically administered pilocarpine would have the undesired effect of

Back 38

A. Decreased heart rate

Front 39

A drug which is a cholinomimetic and a choline ester but has no effect at the skeletal neuromuscular junction

Back 39

E. Bethanechol

Front 40

Pralidoxime is useful to treat overdose by

Back 40

B. Parathion

Front 41

Tacrine is used in the treatment of Alzheimer's disease. Tacrine:

Back 41

A. Is a cholinesterase inhibitor

Front 42

Renin Secretion:

Back 42

E. A and C

A. Increases renal Na and water retention and increases blood pressure

C. Increases total peripheral resistance due to angiotensin II induced vasoconstriction

Front 43

Tropicamide:

Back 43

B. is used as a mydriatic

Front 44

A drug which has inotropic effects in the heart via B1 adrenoreceptors and also induces bronchodilation but does not produce vasoconstriction:

Back 44

D. Isoproterenol

Front 45

Two drugs with the same affinity for a receptor:

Back 45

C. May produce different effects after binding to the receptor

Front 46

You are given the same oral dose of a drug every 24 hours. by the sixth day, the drug seems to have a reduced effectiveness (compared to its effect on the first couple of days). This reduced effectiveness could be the result of

Back 46

A. Increased rate of elimination