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17 Cards in this Set
- Front
- Back
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What are the Phenothiazine anesthetics?
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Chlorpromazine, Acepromazine
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What is the MOA of phenothiazines?
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alpha, dopamine and HI receptor antagonists
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What are the effects of phenothiazines?
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sedation (via D2)
antiemetic (via H1, D2) vasodilation, decreased HR and hypotension (alpha inhibition) NOT analgesic |
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What is the effect of high endogenous levels of histamine, dopamine, ACh?
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can block effects of phenothiazines
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What species should not be given Chlorpromazine?
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horses
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What is fluphenazine?
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phenothiazine that causes serious problems in horses (ataxia, sweating, hyperthermia, dyskinesia, self mutilation)
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What is the MOA of propofol?
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enhances binding of GABA
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What are the effects of propofol?
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apnea
decreases intraocular and intracranial pressure may cause arrythmia poor analgesic, poor muscle relaxant |
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How is propofol metabolized?
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redistributed, then metabolized in liver and excreted by kidney
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What is the main use of propofol?
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induction agent used with others to maintain anesthesia
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What is the MOA of etomidate?
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enhances binding of GABA
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What are the effects of etomidate?
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decreased intraocular pressure
few cardiovascular effects slight respiratory depression no analgesia little muscle relaxation |
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How is etomidate metabolized?
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redistribution, liver metabolism, kidney excretion
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What is the MOA of guaifenesin?
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unknown
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What is the primary effect of guaifenesin?
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muscle relaxation (skeletal)
*can be used as an expectorant |
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What is guaifenesin used for?
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combo with ketamine, xylazine as IV anesthesia in horses
"GKX" or "triple drip" |
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How is guaifenesin metabolized?
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liver metabolism, kidney excretion
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