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14 Cards in this Set
- Front
- Back
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Phenothiazine MOA
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blocks alpha, dopamine-2 & histamine-1 receptors
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Phenothiazine uses
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sedative
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Phenothiazine agents
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Chlorpromazine
Acepromazine Fluphenazine |
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Chlorpromazine characteristics
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Contraindicated in horse - ataxia
In SA, used more as antiemetic more often Vetmed use is off-label |
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Acepromazine
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Used more often as sedative
Labeled use too high - expensive |
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Acepromazine causes what in horses
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penile prolapse
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Acepromazine breed characteristics
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Boxers - too sedate - genetic
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Fluphenazine species effects
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toxicosis in horses - DO NOT USE!
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Fluphenazine characteristics
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extrapyramidal symptoms
May be permanent with even one dose head bobby/pressing |
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Potentcy of Phenothiazines
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Chlorpromazine is less potent
Acepromazine more potent |
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Do phenothiazines produce analgesia
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NO!
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Where are phenothizines metabolized?
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Metabolized in liver
Excreted in the kidney |
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Phenothiazines cause
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vasodilation, decreased blood pressure, decreased catecholamines, minimal depressive respiratory effects,muscle relaxation.
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Acepromazine is FDA approved for what animals
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dogs, cats, horses,
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