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34 Cards in this Set
- Front
- Back
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etiology of scarlet fever
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Grp A strep infected with phage that induces production of erythrogenic toxin
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clinical signs of scarlet fever
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strawberry tongue
desquamation of skin |
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clinical signs of strep pharyngitis
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pain on swallowing
fever focal yellow exudates |
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post strep sequelae
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acute rheumatic fever
acute glomerulonephritis |
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pathogenic mechanism of post strep sequelae
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autoimmunity
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strep pyogenes characteristics
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gram positive cocci
hemolysis on SBA sensitive to bacitracin |
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strep pyogenes is uses what kind of respiration
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facultative anaerobe
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strep pyogenes is sensitive to what antibiotic
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bacitracin
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important strep pyogenes structural virulence factors
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capsule
peptidoglycan layer fibrils consisting of lipoteichoic acid and M protein |
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strep pyogenes attach to what in the respiratory tract
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mucosal epithelial cells via fibrils
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strep pyogenes is plated on what type of medium
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sheep blood agar
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two types of rapid strep tests
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rapid latex agglutination
enzyme immunosorbent assay |
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% of positives that are really positive
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sensitivity
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% of negatives that are really negative
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specificity
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formula for sensitivity
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true pos/(true pos+false neg)
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formula for specificity
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true neg/(true neg+false pos)
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formula for PPV
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true pos/(true pos+false pos)
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formula for NPV
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true neg/(true neg+false neg)
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tx of strep pharyngitis
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penicillin G for 10 days
macrolides (erythromycin) or cephalosporin |
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tx failures in strep pharyngitis is usually caused by
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noncompliance
beta-lactamase copathogen that protects strep |
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early tx (before day 2) causes what
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increased reinfection
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reasons early tx of pharyngitis causes an increase in reinfection
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lack of Ig development
less tissue penetration with antiobiotic |
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diptheria usually effects what population
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infants and children
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diptheria is transmitted by
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air droplets
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severe cases of diptheria can cause
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peripheral vascular collapse and death
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clinical signs of diptheria
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pseudomembrane formation
neck swelling (bull neck) |
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corynebacterium diptheria characteristics
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club shaped appearance
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stain for corynebacterium diptheria
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methylene blue
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odor associated with corynebacterium diptheria
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garlic odor
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virulence of diptheria is produced by what
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an AB toxin
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MOA of diptheria toxin
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blocks protein synthesis by ribosylating EF2
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tx of diptheria
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penicillin
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prevention of diptheria
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immunize with toxoid (DTap)
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2 main bacterial causes of pharyngitis
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strep pyogenes
corynebacterium diptheria |
