Pharmy Exma 3 Pt 2

Front 1

MAO Inhibitors

Back 1

MOA- activation of NE and serotoni recepors, used for tx of depression when other therpaties don’t work , AE- sernototin syndrome, HTN crissis, AE- orthostatic hypotension, urinary retension, xerostomia, CI in narrow angle galucoma, NaHCO3 reverses effects

Front 2

Isocarboxazid, Phenelezine, tranclyoprine, selegline

Back 2

MAOI

Front 3

TCAs

Back 3

MOA- block SERT and NET, increased monoamine cooncentration in cleft , also block adrenergic, muscarininc, histamien and serontin recentpros

Front 4

Amitriptyline, imipramine, amoxapine, maprotiline

Back 4

TCA

Front 5

Clomipramine

Back 5

TCA, little affinity for NET

Front 6

Desipramine

Back 6

TCA, affinity for NET

Front 7

Nortriptyline

Back 7

TCA, affinity for NET

Front 8

SSRIs

Back 8

prevent seronotin uptake, DOC for dperession , used for OCD, PD, anxeity disorlders, PMDD, bulimia , AE- serotonin syndrome , seizures if overdose , not good for chronic pain, not a tx for anorexia

Front 9

Citalopram, Escitalopram, Fluvoxamine, paroxetine

Back 9

SSRI

Front 10

Fluoxetine

Back 10

SSRI, tx of bulimia +PMDD

Front 11

Sertraline

Back 11

SSRI, PMDD

Front 12

SNRIs

Back 12

blocks reuptake of sernotin and NE, seocnd line agent for depression

Front 13

Venlafaxine

Back 13

SNRI , inh of 5HT uptake, high doseses inhibits NE , fever CYP rxns

Front 14

Duloxetine

Back 14

SNRI , inhibits 5HT and NE at ALL doses , fewere CYP rxns , diabetic neuropahty or fibromyphagia pain

Front 15

NDRIs

Back 15

inhibits NE and DA reuptake, increases their release

Front 16

Bupropion

Back 16

NO sexual dysfunctions, NDRI, seziures with overdose , smoking cessation

Front 17

SARIs

Back 17

5HT blockade+ 5HT2 antagonism

Front 18

Nefazodone, Trazodone

Back 18

SARI

Front 19

NASSAs

Back 19

alpha 2 antagonist, enhaces release of NE and 5HT , antagonist at 5T2 and 5HT3

Front 20

Mirtazapine

Back 20

potent H1 antagonist, sedation+ wt gain

Front 21

Lithium

Back 21

prophylkaic in manic depressive pt for mainc epidosne, insitol depresion, MOA- Gq-->IP3, inhibis IP3, blocks regen of insitol and inhibits NE, muscarinic, and 5HT neurotransmision, noncompletive blocker, only active nueros affected- AE- narrow theraptutic window, CONFUSION, COMA, CONVUSIONs, ATAXIA, APHAZIA, CONGEN HRT ISSUES

Front 22

Valproate, Carbamazepine

Back 22

altnerative to Lithium for biopolar

Front 23

Olanzapine, Aripriazole, lamotrigine

Back 23

maintaince of bipolar

Front 24

Quetiapine, Risperidone, Ziprasidone

Back 24

acute mania or mixed bipoalr epsiondes

Front 25

Benzodiazepines

Back 25

binds to GABAa, increased Cl influx, ACTION- reduce axiety, sedative and ypnotic, anticonvulsant, muscle relaxant, anethesia, AE- drpwsomess. Ataxia, cogntibe impairment

Front 26

Alprazolam

Back 26

intermediate acting benzo

Front 27

Clonazepam

Back 27

benzo, epileptic seixure

Front 28

Diazepam

Back 28

long acting benzo, used for skeletal muscle spasms, for MS and cerebral palsy , epileptic seixure, mgmt of ehtanol withdral

Front 29

Flurazepam

Back 29

long acting benzo

Front 30

Lorazepam

Back 30

intermediate acting benzo , no CYP action , epileptic siexire

Front 31

Oxazepam

Back 31

short acting benzo , no CYP action , management of ethanol withdrawal

Front 32

Temazepam

Back 32

intermediate acting benzo , no CYP action

Front 33

Triazolam

Back 33

short acting benzo

Front 34

Barbiturates

Back 34

GABAa recetpors, increase GABA Cl channel openings, can block fglutamante and Na channels , ACTION- low dose- sedation, high dose- hypnosis, anedsiea, coma, resp depression, cyp450 induction, used for hyperbilribuinea, axiety, AE- CNS effects, paradoxical exciement, hanger, CI IN PORYPHYRIA , resp depression, carido collapse, worsens perception of pain , desmythldiazepam- metabolite

Front 35

Pentobarbital

Back 35

long term mgmt of tonic clonic, status epileptcus and eclepsia

Front 36

Thiopental

Back 36

ultra short acting barbituate, IV anestheisa

Front 37

NBBRAs

Back 37

non benzodiazepine receptor agonsits, BZ1 subtype

Front 38

Zolpiden

Back 38

hypnotic, short duraiton of action, insomina with sleep initiation, minimal muslce realxing and anticonvulsansant

Front 39

Zaleplon

Back 39

rapid onset, short duration, short term tx for insomnia

Front 40

Eszopiclone

Back 40

entantiomer of zopiclosen, tx of insomnia, decreases sleep latecny and improves sleep miantians

Front 41

5-HT1A partial

Back 41

less psychomotor impairment, no rxn with alochol, no DI with other serative hypotnic, ne rebound axiety, no depednences

Front 42

Buspirone

Back 42

only anxiolytic, 2-3 w, MOA- antidepresspants , management of onxiety disorders , no other properties

Front 43

Ramelteon

Back 43

MT1 and MT2 agonist at melatonis receptors, tx for insomnia

Front 44

Propranolol

Back 44

performance anxiety

Front 45

Clonidine

Back 45

autonomic expression of anxirty

Front 46

Hydroxyzine

Back 46

antihistimaine with antiemetic, sympottic reified for anxirty

Front 47

Diphenhydramine, doxylamine

Back 47

tx for mild insomina, antihismatines

Front 48

SSRIs

Back 48

DOC for PTSD , social anziety disodrder

Front 49

TCAs

Back 49

effective but less favorable side effect profile

Front 50

Venlafaxine

Back 50

DOC for GAD due to safety and tolerabiltiy

Front 51

Benzodiazepines

Back 51

panic disorder, but not rec long term , alprazolam- rebound anxiety between doses and withrawal syn , initation of antidepressant adjucnt, improve sleep

Front 52

Buspirone

Back 52

no abuse potential, not immegine, seocnd lline for GAD

Front 53

Hydroxyzine, pregablin

Back 53

altnerative for GAD

Front 54

Propranolol

Back 54

performance anxiety

Front 55

Levodopa

Back 55

DOC for parkins with carbidoma

Front 56

DA receptor agonists

Back 56

second line drug for parkinsons

Front 57

Bromocriptine

Back 57

ergot dopamine agonist at D2, use with levodopa , AE- CV, GI, PUL INFILTRATES, PLESURAL fissures, ERTRHYMELAGIA

Front 58

Pramipexole and ropinirole

Back 58

nonergot DA agonist, young pts, better aderverse effect profile

Front 59

Rotigotine

Back 59

transdermal, once daily, not approved in US, nonergot DA agonist

Front 60

Apomorphine

Back 60

non ergot DA agonist, emitogenic, rescue use in pts with off episodes , PRETREAT WITH TRIMETHOBENZAMIDE, AE- QT prolognmaztion, dyskinsia, sweating, bruising at infeciton

Front 61

MAO Inhibitors

Back 61

reduces motor fluctaitons in advanced parkins pts

Front 62

Selegiline

Back 62

selective for MAO-B inh, enhances levodpona, can reduce levodoma, low potential for hypertenive cryssi, adjucnt with levodoma, retards breakdown of DA in brian

Front 63

Rasagiline

Back 63

MAO-B inh for parkinssons

Front 64

COMT inhibitors

Back 64

decreased metab of levosa, decreases plasma levels of 3-O-methyl dopa, incrased uptake of levodopa, higher DA level I nbrain

Front 65

Tolcapone

Back 65

COMT inh, AE- FULMINANT HEPATIC NECROSIS

Front 66

Entacapone

Back 66

NO HEPATOXIVCITY, COMPT inh

Front 67

Amantadine

Back 67

increases syn, release or uptake of DN in suriving neurons, AE- LIVEDO RETICULARIS, acute toxic psyhosis in high doses, peripheral edema, cuation with HF and seizure pts

Front 68

Antimuscarinics

Back 68

useful to control tremor and drooling , DO NOT USE in pts with glacuma, BPH, pyloric stenspis

Front 69

Benztropine, triheyphenydyl

Back 69

antimuscarinic for pkarins

Front 70

Diethylstilbestrol

Back 70

a nonsteroidal estrogen agonist, infertility and vag cancer in female child

Front 71

Estrone

Back 71

lesss pontent than estradiol, from ovary, placenta and blood

Front 72

Estriol

Back 72

lesss pontent than estradiol, from ovary, placenta and blood

Front 73

Progestins

Back 73

contraception, HRT, maintain preg,emdometiriosis, amehroeha dx

Front 74

Medroxyprogesterone and Norgestrol

Back 74

progestins, contraception, HRT, maintain preg,emdometiriosis, amehroeha dx , AE- wt gain, depression, HTN, thromboplfebitis, cholestatic juadice

Front 75

Progesterone

Back 75

elvated during pregans, needed for gestation, decreases uterine contraciltiy, decreases gall bladder contracitn, high dose supresses gonadropic-->anovulaiton

Front 76

Androgens

Back 76

thperay for hypogonadism, increases bone density for ostoepsorisis, increases muscle mass, AE- APLASTNIC ANEMIA, HIRSUITISM, HEPATIC ADENOMA, PROSTTIC HYPERTRPHY , ELEVATED TRANSAMINASE

Front 77

Testosterone

Back 77

androgens, thperay for hypogonadism, increases bone density for ostoepsorisis, increases muscle mass, AE- APLASTNIC ANEMIA, HIRSUITISM, HEPATIC ADENOMA, PROSTTIC HYPERTRPHY

Front 78

Oxandrolone, Stanozol, fluoxymestrone, oxymetholoine, nandrolone

Back 78

synthetic androgens, thperay for hypogonadism, increases bone density for ostoepsorisis, increases muscle mass, AE- APLASTNIC ANEMIA, HIRSUITISM, HEPATIC ADENOMA, PROSTTIC HYPERTRPHY

Front 79

Danazol

Back 79

partial agonist of progestin, androgemn and glucocorticoid receptors, USE- endometriosis and fibrocyis breast, CYP int, AE- ABN LFTs

Front 80

SERMs

Back 80

slelctive estrogen receptor molduatiosn

Front 81

Tamoxifen

Back 81

SERMs, antagonist at breast, RISK OF ENDOMET CA, hot flushes, thromia, TX OF BREAST CA

Front 82

Raloxifene

Back 82

breast antagonist, agonsit at bone, NO RISK OF ENDOMETRIAL CA, propylsaix for breast CA in high risk pts, prevents osteoprosis

Front 83

Clomiphene

Back 83

estrogen antagonsit in hypothalamus and atnerior pitautin, prevents negative feedback, tx for interterizit, AE- OVARIAN HYERSTIM SYNDROME, ovarian enalgement, multible preg, visual distubmances

Front 84

Fulvestrant

Back 84

estronge receptor antagonist, breast ca in tamoxifen res pts

Front 85

letrozole, Anastrazole, Exemestane

Back 85

inhibits coversion of androgen to estrogiel , aromatase inh, 2nd line for breast CA after tamoxi

Front 86

Mifepristone

Back 86

antiprogestin, competive inh of progestrone receptors, morning after, give with PG E or F to increase myometrial contraciotn, AE- bleeding, GI, abd pain

Front 87

Leuprolide

Back 87

GnRH releasing analog, CONTINOUS DOSE- REVERSIBLE MED CASTRATION, PROSTATIC CA

Front 88

Flutamide

Back 88

androgen receptor agonsit used with GnRH to decrease tumor flareups , PROSTATIC CA

Front 89

Bicalutamide

Back 89

androgen receptor agonsit used with GnRH to decrease tumor flareups

Front 90

Nilutamide

Back 90

androgen receptor agonsit used with GnRH to decrease tumor flareups

Front 91

Cyproterone

Back 91

TX FOR HIRUISTISM , antiandorgenic

Front 92

Spironolactone

Back 92

TX FOR HIRUISTISM , antiandorgenic