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160 Cards in this Set
- Front
- Back
|
Thyroxine
|
T4 , increases BMR, increases effects of catechlaines, CNS development , las levothyroixine, longer half life
|
|
|
Triiodothyronine
|
T3 , shroter half life
|
|
|
Propylthiouracil
|
DOC for thyroid storm, imparis coversion of T4 to T3, 3 times a day, safer in preg , block iodinzation and inhbit couling of DIT with MIT, reduced T3 and T4 , AE- AGRANULOCYTOSIS, VASCULITIS , hyperprothrombuemia
|
|
|
Methimazole
|
daily dose, less AE than PTU
|
|
|
Iodide
|
decreases vascularity and size of gland, most often before surgery, use with PTU and B blocker in thryotoxic crisis , AE- IODISM, ANGIOEDEMA, BURNIG GUMS, ENLAGEMETN OF PAROTID
|
|
|
Iodine
|
lugons solution- iodine and potasium, used for surgery to decrease facsularity, AE- IODISM, ANGIOEDEMA, BURNIG GUMS, ENLAGEMETN OF PAROTID
|
|
|
131I
|
taken up and sequentered by thryoid gland, damanges tissue, by beta particles, used in hyertrhyoridism when refractory to drugs and subtotal thyrodecop, AE- HYPOTHRYODISM, permemant reduction in thryoid active, CI in preg women and nursiing mothers
|
|
|
Diatrizoate
|
oral, iodinated radiocontrast medio, supreses coversion of T4 to T3 in periperhal tissue, kindey and liver, reduces T3 in thryotcivosis
|
|
|
Iohexol
|
IV, iodinated radiocontrast medio, supreses coversion of T4 to T3 in periperhal tissue, kindey and liver, reduces T3 in thryotcivosis
|
|
|
Perchlorate, thiocyanate, pertechnetate
|
ihibit iodidie concetration in gland by blocking transforation. AE- APLASTIC ANEMIA
|
|
|
Propranolol
|
nonspecific B blockers, preventiosn converison of T4 to T3
|
|
|
Esmolol
|
short acting B blocekr unsed to control intraoperatie thryoid storm
|
|
|
Glucocorticoids
|
used in thryoid storp with PTU and NaI, ihibits peripeheral conversion of T4 to T3
|
|
|
Interferon
|
provoke autimine/destructive inflammatory thryodisim-->hypothryodisim
|
|
|
Interleukin-2
|
provoke autimine/destructive inflammatory thryodisim-->hypothryodisim
|
|
|
Amiodarone
|
ihibits converion of T4 to T3 , sttucutrally similar to thryoxine, iodine associated hyperthyroidism-->tx with thiamides, autoimmune mediated with infl version of tx with steroids, hypothryodism due to blockage of T4 to T3
|
|
|
Lithium
|
ihibits release of hormoes(hypothroidism) and thyroid enlagement
|
|
|
Teriparatide
|
recomb PTH, useful for tx of osteoporosis , pulsatie-->bone formation
|
|
|
Vitamin D
|
activates steroidal nuclear receptor , supplements for osteprosis, CRF, nutrional rickets, chronic lvier disease, AE- hyercalcemia and hyperphophatemia
|
|
|
Cholecalciferol
|
vit D3, supplement added to dairy products
|
|
|
Ergocalciferol
|
vit D2 , supplement addedto dairy products
|
|
|
Calcitriol
|
tx of secondary hyperparathryoidsim in CRF and liver disease, tx of psoriasis , vitamin D3
|
|
|
Doxercalciferol
|
1 alpha hydroxyvitamin D2
|
|
|
Paricalcitol
|
19-nor-1,25 didryoxyvitD2
|
|
|
Calcipotriol
|
calciproteine
|
|
|
Calcitonin
|
peptide hormine, tx of osteporisis, increase bone pass and reduces spinar facutres, salmon calcitonsin0 logner half life
|
|
|
Calcium salts
|
ca gluconate- tx for hypocalcemic tetany, others used for overdose of mg sulfate and eclempsia, AE- NECROSIS AND ABCESS AT INJECTION SITE
|
|
|
Tamoxifen
|
breast CA and helps with bome, incfrease risk of endometiral CA, hot flushes and thromboembolism
|
|
|
Raloxifene
|
tx of ospeorsis in post menopausla women, AE- thromboembolism, HOT FLUSHES
|
|
|
Bisphosphonates
|
ihbit osteoclastic activity by distruping mevalonate pathway to decrease osteoclast H ATPase , tx for pagets dsiease, osteoprisis and maiglancy associated hypercalcemia, AE- EROSIVE ESOPHAGITIS
|
|
|
Etidronate
|
can lead to osteomalacia if used for more than 12 months , a bisphonate avialbe in IV
|
|
|
Alendronate, Pamidronate, risdronate
|
bisphonates
|
|
|
Cinecalcet
|
activates calcium sensing receptors in parathroid cells, PTH surpesison, syntehsis and release, seocndary hyperpatrathyridism, CRF and pts with malignancy, AE- hypocalcemia, decreased bone cell activity
|
|
|
Sevelamer
|
phosphate bidning drugs used to prevent hyperphosphatemia in pts with CRF, binds to dietary phophate and prevents its absopriton
|
|
|
Fluoride
|
chronic epxosure can lead to new bone synthesi which is denser but brittle
|
|
|
Gallium nitrate
|
ihbhits bone resorption, canter rel hypercalcemia, nephrotoxic
|
|
|
Plicamycin
|
cytotoxic antiVA drug, cancer rel hypercacemia, AE- HEPATIC ANDRENAL TOXCIITY
|
|
|
Thiazides
|
decreases excretion of Ca by increasing reabsopriton, prevnets renal stone formation, tx of HTN in osteoporosis pt
|
|
|
Echinacea
|
activates cytoyutes IL 1, TNF, antiinf, AE- UNPLEASTANT taste, GI, HA , for cold E purpuira
|
|
|
Ginkgo
|
G biloba, antioxidant, reduces blood viscosits and changes NT, for INTERMITTEN CALDUCATION, cerebral insuff, dementia, AE- EPLIPTOGENIC, INSOMNIA, HA, anxiety, GI
|
|
|
Ginseng
|
triterpenoid saponin glycsines, improves mental and physical performantes, type II DM, AE- mastalgia and bag bleeding, nervousness, insomnia, interact with anticoag, hypogycemia, psychiatric meds
|
|
|
Glucosamine
|
nitrogen containing sumar major compent of glycosiminayglyacans, used for tx of OA, decreases pain, AE- GI and Allergy
|
|
|
Kava
|
sedative proerpties, short term social anxiety, liver toxciity from leaves and stems, heavy use- wt loss, rash, elevated GGT, renal dysfunction, rahses, blood abnormalties
|
|
|
Milk Thistle
|
from Silybium marianum, increases hepatic RNA pol acrivity, cytoprotective agaisnt hepatic injury by alcohol and amnita mushroom poisoing
|
|
|
Saw Palmetto
|
from sabal serullata, decreases 5 alpha reductase and antagonistic effects of androgen receptors tx- BPH, AE- DECREASED LIBIDO and HTN
|
|
|
Coenzyme Q10
|
cofactor for mitochondrial electrol trnasport, ubiquinol reduced- antiboxidant, tx for CAD and chronic stable angina, migraine attacsks, AE- THROMOCYTOPENIA, rash, HA, irritabiltiy
|
|
|
Melatonin
|
n acetyl 5 methyoxytryptaime, sernotinin dervies, improves sleep and duration, AE- day time drowsiness
|
|
|
Black Cohosh
|
actea racemosa, prepartion in tincutres or tabelts, for menopause and premenestural tension, binds and activates serotonin receptors
|
|
|
Sermorelin
|
GHRH analog , used for GH def, don’t use with GH def from anterior pituiary
|
|
|
Mecasermin
|
combo of recomb human IGF1 and recomb IGF bifning protein 3, AE- HYPOGLYCEMIA, intercranial hypertension, elevation of lier enzymes
|
|
|
Somatropin
|
recompbinant GH , AE(kids)-hypothryodism, intergranial hypertnesion, SCOLIOSIS, OTITIS MEDIA, PACNREATISI, GYNECOMASTIA, DIABETIC SYNDROME , AE(adults)- peripheral edema, myalgia, atralgial, carpe tunnel, prolif retinalry, CI- PTs with known malignancs
|
|
|
Somatrem
|
GH analog
|
|
|
Pegvisomant
|
GH receptor antagonist
|
|
|
Thyroxine
|
T4 , increases BMR, increases effects of catechlaines, CNS development , las levothyroixine, longer half life
|
|
|
GnRH & analogs
|
GhRH analogi, pulsatile- stimualtes LH and FSH, sustained- inhibits FSH and LH, analogs are logner lasting and more poetnit
|
|
|
Triiodothyronine
|
T3 , shroter half life
|
|
|
Gonadorelin
|
GnRH analog, acetate salth of syntehtic human GnRH, short half life, for male infertility(pulsatile), dx of LH responsivness to check for delayed puberty
|
|
|
Propylthiouracil
|
DOC for thyroid storm, imparis coversion of T4 to T3, 3 times a day, safer in preg , block iodinzation and inhbit couling of DIT with MIT, reduced T3 and T4 , AE- AGRANULOCYTOSIS, VASCULITIS , hyperprothrombuemia
|
|
|
Leuprolide
|
GnRH analog,
|
|
|
Methimazole
|
daily dose, less AE than PTU
|
|
|
Nafarelin
|
GnRH analog
|
|
|
Iodide
|
decreases vascularity and size of gland, most often before surgery, use with PTU and B blocker in thryotoxic crisis , AE- IODISM, ANGIOEDEMA, BURNIG GUMS, ENLAGEMETN OF PAROTID
|
|
|
Goserelin
|
GnRH analog
|
|
|
Iodine
|
lugons solution- iodine and potasium, used for surgery to decrease facsularity, AE- IODISM, ANGIOEDEMA, BURNIG GUMS, ENLAGEMETN OF PAROTID
|
|
|
Cetrorelix, Ganirelix
|
GnRH receptor antagonist , competiive antagonist of GnRH, used to supress gonadrotropic production , prevents LH surge during controlled ovarian hyperstimulation
|
|
|
131I
|
taken up and sequentered by thryoid gland, damanges tissue, by beta particles, used in hyertrhyoridism when refractory to drugs and subtotal thyrodecop, AE- HYPOTHRYODISM, permemant reduction in thryoid active, CI in preg women and nursiing mothers
|
|
|
Corticotropin, cosyntropin
|
ACTH antagonist , acts via MC2R to stimulate adrenal cortex to secrete glucocorticoids, mineralocorticoids and androgen precuror , limited utilbity, USE- dx primary vs secodnary adrenal insur, INFANTILE SPASM
|
|
|
Diatrizoate
|
oral, iodinated radiocontrast medio, supreses coversion of T4 to T3 in periperhal tissue, kindey and liver, reduces T3 in thryotcivosis
|
|
|
Gonadotropin analogs
|
ovulation induction, male infertility , AE- OVARIAN HY{ERSTIMUPATION SYNDDROME<, multiple pregnancies, GYNECOMASTIA IN MEN
|
|
|
Iohexol
|
IV, iodinated radiocontrast medio, supreses coversion of T4 to T3 in periperhal tissue, kindey and liver, reduces T3 in thryotcivosis
|
|
|
Follitropin
|
purified FSH , used for infertility , gonadotropins
|
|
|
Perchlorate, thiocyanate, pertechnetate
|
ihibit iodidie concetration in gland by blocking transforation. AE- APLASTIC ANEMIA
|
|
|
Urofollitropin
|
purified FSH extract, used for infertility , gonadotropins , male inferitlity in combo with rFSH and rLH
|
|
|
Propranolol
|
nonspecific B blockers, preventiosn converison of T4 to T3
|
|
|
hCG
|
extracted and purified from urine(IM) , gonadotropins , male infertiltiy
|
|
|
Esmolol
|
short acting B blocekr unsed to control intraoperatie thryoid storm
|
|
|
Menotropins
|
purified extract of FSH and LH, used for infertility
|
|
|
Glucocorticoids
|
used in thryoid storp with PTU and NaI, ihibits peripeheral conversion of T4 to T3
|
|
|
Vasopressin agonists
|
AE- overdose- HYPONATREMIA, SEZIDURES, ALLERFIES
|
|
|
Interferon
|
provoke autimine/destructive inflammatory thryodisim-->hypothryodisim
|
|
|
Vasopressin
|
DOC for DI for esophageal variceal bleeding and clonic diverticular bleeding , vasopressin agonist
|
|
|
Interleukin-2
|
provoke autimine/destructive inflammatory thryodisim-->hypothryodisim
|
|
|
Desmopressin
|
DOC for DI for coagulopahty tx in hem A and von willibram , vasopressin agonsit , long acting
|
|
|
Amiodarone
|
ihibits converion of T4 to T3 , sttucutrally similar to thryoxine, iodine associated hyperthyroidism-->tx with thiamides, autoimmune mediated with infl version of tx with steroids, hypothryodism due to blockage of T4 to T3
|
|
|
Atosiban
|
oxytocin antagonist used for preterm labor(not in US)
|
|
|
Lithium
|
ihibits release of hormoes(hypothroidism) and thyroid enlagement
|
|
|
Beclomethasone
|
synthetic glucocrotiicyoid, short half life and penetrates airway mucosa, low toxicity
|
|
|
Teriparatide
|
recomb PTH, useful for tx of osteoporosis , pulsatie-->bone formation
|
|
|
Dexamethasone
|
to mature lungs in fetus , cushing syndrome test, depressive psychatric states , synthetic glucocrotiicyoid
|
|
|
Vitamin D
|
activates steroidal nuclear receptor , supplements for osteprosis, CRF, nutrional rickets, chronic lvier disease, AE- hyercalcemia and hyperphophatemia
|
|
|
Methylprednisolone, triamcinolone
|
synthetic glucocrotiicyoid
|
|
|
Cholecalciferol
|
vit D3, supplement added to dairy products
|
|
|
Prednisone
|
synthetic glucocrotiicyoid, hodgkinds lympmona
|
|
|
Ergocalciferol
|
vit D2 , supplement addedto dairy products
|
|
|
Aldosterone
|
promotes Na reabs from nreal tubule, promote K and H excretion, salt retaining
|
|
|
Calcitriol
|
tx of secondary hyperparathryoidsim in CRF and liver disease, tx of psoriasis , vitamin D3
|
|
|
Fludrocortisone
|
use for addions with daily hydrocortisone and for congential adrenal hyperplasia
|
|
|
Doxercalciferol
|
1 alpha hydroxyvitamin D2
|
|
|
Mifepristone
|
antagonist at glucocorticoid and progestrone receptors , Use- econtomic ACTH syndrome or adrenal carcinoma,
|
|
|
Paricalcitol
|
19-nor-1,25 didryoxyvitD2
|
|
|
Spironolactone
|
comptes with alodsterone, use- aldosteronsm, HIRSTUITISN, DUIRECTIC, AE- HYPERKALEMIA, arrtymais, GYNECPASIMAS, sedation
|
|
|
Calcipotriol
|
calciproteine
|
|
|
Ketoconazole
|
non selective inhibitor of adrenal and gonadal steroid syntehsis - USE- cushings syndrome, prostrate CA
|
|
|
Calcitonin
|
peptide hormine, tx of osteporisis, increase bone pass and reduces spinar facutres, salmon calcitonsin0 logner half life
|
|
|
Aminoglutethimide
|
blocks conversion of cholestrol to pregnamte, reduces syn of all hormonarry acive sterids, use- adrenal cancer
|
|
|
Calcium salts
|
ca gluconate- tx for hypocalcemic tetany, others used for overdose of mg sulfate and eclempsia, AE- NECROSIS AND ABCESS AT INJECTION SITE
|
|
|
Metyrapone
|
selective inh of 11 OH, interferences with cortisol and corticosterone synthesis , Use- adrenal function, tx of preg women with cushingds, AE- HIRSTUITISM, dizzeness GI, SALT AND WATER RETENTION
|
|
|
Tamoxifen
|
breast CA and helps with bome, incfrease risk of endometiral CA, hot flushes and thromboembolism
|
|
|
Raloxifene
|
tx of ospeorsis in post menopausla women, AE- thromboembolism, HOT FLUSHES
|
|
|
Bisphosphonates
|
ihbit osteoclastic activity by distruping mevalonate pathway to decrease osteoclast H ATPase , tx for pagets dsiease, osteoprisis and maiglancy associated hypercalcemia, AE- EROSIVE ESOPHAGITIS
|
|
|
Etidronate
|
can lead to osteomalacia if used for more than 12 months , a bisphonate avialbe in IV
|
|
|
Alendronate, Pamidronate, risdronate
|
bisphonates
|
|
|
Cinecalcet
|
activates calcium sensing receptors in parathroid cells, PTH surpesison, syntehsis and release, seocndary hyperpatrathyridism, CRF and pts with malignancy, AE- hypocalcemia, decreased bone cell activity
|
|
|
Sevelamer
|
phosphate bidning drugs used to prevent hyperphosphatemia in pts with CRF, binds to dietary phophate and prevents its absopriton
|
|
|
Fluoride
|
chronic epxosure can lead to new bone synthesi which is denser but brittle
|
|
|
Gallium nitrate
|
ihbhits bone resorption, canter rel hypercalcemia, nephrotoxic
|
|
|
Plicamycin
|
cytotoxic antiVA drug, cancer rel hypercacemia, AE- HEPATIC ANDRENAL TOXCIITY
|
|
|
Thiazides
|
decreases excretion of Ca by increasing reabsopriton, prevnets renal stone formation, tx of HTN in osteoporosis pt
|
|
|
Echinacea
|
activates cytoyutes IL 1, TNF, antiinf, AE- UNPLEASTANT taste, GI, HA , for cold E purpuira
|
|
|
Ginkgo
|
G biloba, antioxidant, reduces blood viscosits and changes NT, for INTERMITTEN CALDUCATION, cerebral insuff, dementia, AE- EPLIPTOGENIC, INSOMNIA, HA, anxiety, GI
|
|
|
Ginseng
|
triterpenoid saponin glycsines, improves mental and physical performantes, type II DM, AE- mastalgia and bag bleeding, nervousness, insomnia, interact with anticoag, hypogycemia, psychiatric meds
|
|
|
Glucosamine
|
nitrogen containing sumar major compent of glycosiminayglyacans, used for tx of OA, decreases pain, AE- GI and Allergy
|
|
|
Kava
|
sedative proerpties, short term social anxiety, liver toxciity from leaves and stems, heavy use- wt loss, rash, elevated GGT, renal dysfunction, rahses, blood abnormalties
|
|
|
Milk Thistle
|
from Silybium marianum, increases hepatic RNA pol acrivity, cytoprotective agaisnt hepatic injury by alcohol and amnita mushroom poisoing
|
|
|
Saw Palmetto
|
from sabal serullata, decreases 5 alpha reductase and antagonistic effects of androgen receptors tx- BPH, AE- DECREASED LIBIDO and HTN
|
|
|
Coenzyme Q10
|
cofactor for mitochondrial electrol trnasport, ubiquinol reduced- antiboxidant, tx for CAD and chronic stable angina, migraine attacsks, AE- THROMOCYTOPENIA, rash, HA, irritabiltiy
|
|
|
Melatonin
|
n acetyl 5 methyoxytryptaime, sernotinin dervies, improves sleep and duration, AE- day time drowsiness
|
|
|
Black Cohosh
|
actea racemosa, prepartion in tincutres or tabelts, for menopause and premenestural tension, binds and activates serotonin receptors
|
|
|
Sermorelin
|
GHRH analog , used for GH def, don’t use with GH def from anterior pituiary
|
|
|
Mecasermin
|
combo of recomb human IGF1 and recomb IGF bifning protein 3, AE- HYPOGLYCEMIA, intercranial hypertension, elevation of lier enzymes
|
|
|
Somatropin
|
recompbinant GH , AE(kids)-hypothryodism, intergranial hypertnesion, SCOLIOSIS, OTITIS MEDIA, PACNREATISI, GYNECOMASTIA, DIABETIC SYNDROME , AE(adults)- peripheral edema, myalgia, atralgial, carpe tunnel, prolif retinalry, CI- PTs with known malignancs
|
|
|
Somatrem
|
GH analog
|
|
|
Pegvisomant
|
GH receptor antagonist
|
|
|
GnRH & analogs
|
GhRH analogi, pulsatile- stimualtes LH and FSH, sustained- inhibits FSH and LH, analogs are logner lasting and more poetnit
|
|
|
Gonadorelin
|
GnRH analog, acetate salth of syntehtic human GnRH, short half life, for male infertility(pulsatile), dx of LH responsivness to check for delayed puberty
|
|
|
Leuprolide
|
GnRH analog,
|
|
|
Nafarelin
|
GnRH analog
|
|
|
Goserelin
|
GnRH analog
|
|
|
Cetrorelix, Ganirelix
|
GnRH receptor antagonist , competiive antagonist of GnRH, used to supress gonadrotropic production , prevents LH surge during controlled ovarian hyperstimulation
|
|
|
Corticotropin, cosyntropin
|
ACTH antagonist , acts via MC2R to stimulate adrenal cortex to secrete glucocorticoids, mineralocorticoids and androgen precuror , limited utilbity, USE- dx primary vs secodnary adrenal insur, INFANTILE SPASM
|
|
|
Gonadotropin analogs
|
ovulation induction, male infertility , AE- OVARIAN HY{ERSTIMUPATION SYNDDROME<, multiple pregnancies, GYNECOMASTIA IN MEN
|
|
|
Follitropin
|
purified FSH , used for infertility , gonadotropins
|
|
|
Urofollitropin
|
purified FSH extract, used for infertility , gonadotropins , male inferitlity in combo with rFSH and rLH
|
|
|
hCG
|
extracted and purified from urine(IM) , gonadotropins , male infertiltiy
|
|
|
Menotropins
|
purified extract of FSH and LH, used for infertility
|
|
|
Vasopressin agonists
|
AE- overdose- HYPONATREMIA, SEZIDURES, ALLERFIES
|
|
|
Vasopressin
|
DOC for DI for esophageal variceal bleeding and clonic diverticular bleeding , vasopressin agonist
|
|
|
Desmopressin
|
DOC for DI for coagulopahty tx in hem A and von willibram , vasopressin agonsit , long acting
|
|
|
Atosiban
|
oxytocin antagonist used for preterm labor(not in US)
|
|
|
Beclomethasone
|
synthetic glucocrotiicyoid, short half life and penetrates airway mucosa, low toxicity
|
|
|
Dexamethasone
|
to mature lungs in fetus , cushing syndrome test, depressive psychatric states , synthetic glucocrotiicyoid
|
|
|
Methylprednisolone, triamcinolone
|
synthetic glucocrotiicyoid
|
|
|
Prednisone
|
synthetic glucocrotiicyoid, hodgkinds lympmona
|
|
|
Aldosterone
|
promotes Na reabs from nreal tubule, promote K and H excretion, salt retaining
|
|
|
Fludrocortisone
|
use for addions with daily hydrocortisone and for congential adrenal hyperplasia
|
|
|
Mifepristone
|
antagonist at glucocorticoid and progestrone receptors , Use- econtomic ACTH syndrome or adrenal carcinoma,
|
|
|
Spironolactone
|
comptes with alodsterone, use- aldosteronsm, HIRSTUITISN, DUIRECTIC, AE- HYPERKALEMIA, arrtymais, GYNECPASIMAS, sedation
|
|
|
Ketoconazole
|
non selective inhibitor of adrenal and gonadal steroid syntehsis - USE- cushings syndrome, prostrate CA
|
|
|
Aminoglutethimide
|
blocks conversion of cholestrol to pregnamte, reduces syn of all hormonarry acive sterids, use- adrenal cancer
|
|
|
Metyrapone
|
selective inh of 11 OH, interferences with cortisol and corticosterone synthesis , Use- adrenal function, tx of preg women with cushingds, AE- HIRSTUITISM, dizzeness GI, SALT AND WATER RETENTION
|
