Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
NSAIDs 4
|
Analgesicu
Antiinflammatoryu Antipyreticu Aspirin-plateletinhibition |
|
|
NSAIDs arealso used for the relief of: 3 |
uReliefof the pain associated with arthritic disorders, such as rheumatoid arthritis,juvenile arthritis, ankylosingspondylitis, and osteoarthritisu
Treatmentof gout and hyperuricemia |
|
|
uBlockingthe chemical activity of the enzyme called cyclooxygenase (COX)
|
NSAIDs: Mechanism of Action
|
|
|
ucyclooxygenase(COX) 2 + 2 +2
|
Cyclooxygenase-1(COX-1) Hasa role in maintaining the GI mucosa, Regulationof gastric acid and kidney water excretion
Cyclooxygenase-2(COX-2) Usedfor signaling pain and inflammation, Stimulatedby immune response |
|
|
Irreversibleinhibitor of COX-1 receptors within the platelets themselves
Reducedformation of thromboxane A2, a substancethat normally promotes platelet aggregation Other NSAIDslack these antiplatelet effects |
Aspirin
Cancause gastric ulcers by stopping cox 1 whichhelps coat the stomach |
|
|
Chemical Categories of NSAIDs 4
|
Salicylates
Cyclooxygenase-2(COX-2) inhibitors Enolicacid derivatives Propionicacid derivatives |
|
|
Inhibitsplatelet aggregation
Antithromboticeffect: used inthe treatment of MI and other thromboembolic disorders |
Salicylic acid (aspirin)
|
|
|
____ – Do not give ASA to infants. Give Tylenol instead
|
Reye’s syndrome
|
|
|
First and onlyremaining COX-2 inhibitor
|
celecoxib (Celebrex)
|
|
|
Propionic Acid Derivatives
2+3 |
ibuprofen(Motrin,Advil)
naproxen(Aleve) |
|
|
Used for their analgesic effects in treating rheumatoidarthritis, osteoarthritis, primary dysmenorrhea, gout, dental pain, andmusculoskeletal disorders |
Propionic Acid Derivatives
|
|
|
____ hasfewer drug interactions with angiotensin-converting enzyme inhibitors given forhypertension
|
Naproxen
|
|
|
NSAIDs: Adverse Effects 1
____ can be used to reduce these dangerous effects. |
GIbleeding*
Misoprostol (Cytotec) |
|
|
NSAIDs: Adverse Effects
Renal 1 |
Acutetubular necrosis with renal failure
|
|
|
_____disrupt the prostaglandins, which stimulate vasodilation and increase renalblood flow. This disruption may precipitate chronic or acute renal failure insome patients, and elderly patients are at greater risk for this adverse drugreaction.
|
NSAIDs
|
|
|
NSAIDs: Salicylate Toxicity 4
|
Tinnitus, hearing loss, drowsiness
hyperventilation |
|
|
NSAIDs: Interactions 5
|
Anticoagulants
Aspirin Corticosteroidsand other ulcerogenicdrugs Proteinbound drugs Diureticsand ACE inhibitors |
|
|
_____:condition that results from inappropriate uric acid metabolism
Underexcretionof uric acid Overproductionof uric acid |
Gout
|
|
|
Antigout Drugs 1
|
allopurinol(Zyloprim)
|
|
|
Used to prevent uric acid production.
|
allopurinol (Zyloprim)
|
|
|
Reducesinflammatory response to the deposits of uratecrystals in joint tissue
|
colchicine
|
|
|
Antigout Drugs
Maycause short-term leukopenia and bleeding into the gastrointestinal or urinarytracts _____ if bleeding is noted |
Call HCP
|
|
|
HerbalProducts:
Usedto treat the pain of osteoarthritis |
Glucosamine and Chondroitin
|
|
|
Glucosamine and Chondroitin interactions 2
|
Enhanceseffects of warfarin
Mayincrease insulin resistance (glucosamine) |
|
|
Do not give_____ to children and teenagers because of the risk of Reye’s syndrome
|
salicylates
|
|
|
Anti-inflammatory drugs
Becausethese drugs generally cause GI distress, they are often better tolerated if 3 |
taken with food, milk, or an antacid to avoid irritation
|
|
|
Advisepatients that enteric-coated tablets should not be crushed or chewed
|
nursing
|
